RuvB-Like 1 (E. Coli) (RUVBL1) Peptide
RUVBL1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all RUVBL1 products
- RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-RUVBL1 antibody (Catalog #: ARP32349_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))
- Synonyms
- rvb1 Peptide, ecp54 Peptide, tip49 Peptide, nmp238 Peptide, pontin Peptide, tip49a Peptide, xpontin Peptide, pontin52 Peptide, TIP49 Peptide, wu:fd18e04 Peptide, zpontin Peptide, ECP54 Peptide, INO80H Peptide, NMP238 Peptide, PONTIN Peptide, Pontin52 Peptide, RVB1 Peptide, TIH1 Peptide, TIP49A Peptide, Tip49a Peptide, 2510009G06Rik Peptide, RuvB like AAA ATPase 1 Peptide, RuvB-like 1 (E. coli) Peptide, RuvB-like 1 Peptide, RuvB like AAA ATPase 1 S homeolog Peptide, RuvB-like AAA ATPase 1 Peptide, RuvB-like protein 1 Peptide, RUVBL1 Peptide, ruvbl1 Peptide, PVX_123295 Peptide, Bm1_15605 Peptide, ruvb1 Peptide, ruvbl1.S Peptide, Ruvbl1 Peptide
- Background
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RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
Alias Symbols: ECP54, NMP238, Pontin52, RVB1, TIH1, TIP49, TIP49A, INO80H, PONTIN
Protein Interaction Partner: CD82,KAT5,KLK3,ACTL6A,C20orf20,CTNNB1,KIAA1377,PLG,RUVBL2,TBP,ACTB,ACTG1,ACTL6A,C12orf45,C1orf57,C2orf44,CAPNS1,CCDC87,CDK9,CTNNB1,DDX42,DMAP1,DNASE2,DPCD,E2F7,ELAVL1,EP400,FDFT1,GNAS,GPN1,HLA-B,HSPA1L,HSPA8,ING3,KIAA1377,KPNB1,LEF1,MEPCE,MLH1,MYC,OFD1,PCBP1,PCBP2,PCBP3,PELO,PIH1D1,PMS2,PSTPIP1,RUVBL2,SMARCA2,SMNDC1,SRI,STAP1,TBP,TRRAP,TTI1,YEATS4
Protein Size: 456 - Molecular Weight
- 50 kDa
- Gene ID
- 8607
- NCBI Accession
- NM_003707, NP_003698
- UniProt
- Q9Y265
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