SMAD, Mothers Against DPP Homolog 2 (SMAD2) (N-Term) Peptide
SMAD2
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all SMAD2 products
- SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SMAD2 antibody (Catalog #: ARP32004_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
- Synonyms
- JV18 Peptide, JV18-1 Peptide, MADH2 Peptide, MADR2 Peptide, hMAD-2 Peptide, hSMAD2 Peptide, jv18 Peptide, Xmad2 Peptide, madh2 Peptide, madr2 Peptide, XSmad2 Peptide, hmad-2 Peptide, hsmad2 Peptide, jv18-1 Peptide, smad-2 Peptide, fj43c06 Peptide, wu:fj43c06 Peptide, 7120426M23Rik Peptide, Madh2 Peptide, Madr2 Peptide, Smad-2 Peptide, mMad2 Peptide, MAD homolog 2 Peptide, Mothers against DPP homolog 2 Peptide, SMAD 2 Peptide, Smad2 Peptide, SMAD family member 2 Peptide, SMAD family member 2-Z Peptide, SMAD family member 2 S homeolog Peptide, SMAD2 Peptide, SMAD2Z Peptide, smad2 Peptide, smad2.S Peptide, Smad2 Peptide
- Background
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SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD2 mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, SMAD2 is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed.
Alias Symbols: JV18, JV18-1, MADH2, MADR2, MGC22139, MGC34440, hMAD-2, hSMAD2
Protein Interaction Partner: PML,ANAPC10,BRCA1,CDK2,CDK4,CREBBP,CREBBP,E1A,EP300,FOXH1,FOXH1,LEMD3,SKI,SKIL,SMAD3,SMAD3,SMAD4,SMAD4,SMURF2,SNW1,TGFBR1,ABTB1,ACVR1B,AKT1,ANAPC10,ANAPC2,ANK3,ANTXR2,AP1B1,ARFGAP3,ARHGEF6,ARL4D,AXIN1,BAZ1A,BRCA1,BTBD2,CAMK2A,CDC16,CDC27,CDC40,CDK4,CISH,COPS5,CREBBP,CSH1,CTNNB1,CUL5,CYP11A1,DAB2,DCAF6,DCUN1D1,DNAJC7,DVL1,DYNC1H1,E2F4,EEF1A1,EID2,EIF3L,EP300,ERBB2IP,ESR1,ESR2,FBN2,FOXG1,FOXH1,FOXO3,GATAD2B,GLI3,GRIPAP1,GSC,GTF2I,HDAC1,HGS,HIPK2,HNF4A,HOXA13,HOXA9,HOXD13,HUWE1,INSR,IRAK2,JUN,KAT2B,KHDRBS1,KPNB1,LAMA5,LEF1,LEMD3,LHX9,LITAF,LMO2,MAPK1,MAPK3,MAPK8,MAPK9,MED15,MED6,MEF2A,MEF2C,MLLT4,MYC,NAGK,NCOA6,NEDD9,NFYC,NOTCH4,NUAK2,NUP153,NUP214,OS9,PAK1,PAPOLA,PAPPA,PARD3,PEX19,PIAS3,PIAS4,PLIN3,PPM1A,PPP2R1A,PRKAR1A,PSAP,PSG9,PSMD11,PSMD8,RAB34,RAB38,RAN,RANBP9,RARB,RASD2,RASL12,RBL1,RHEBL1,RHOD,RHOJ,RIT1,RNF123,ROCK1,RPS14,RPS27A,RUNX2,RXRA,SKI,SKIL,SMAD2,SMAD3,SMAD4,SMAD4,SMAD9,SMURF2,SNAPIN,SNIP1,SNRNP70,SNW1,SP1,SQSTM1,SRI,ST13,ST5,STAG1,STAMBP,STAMBPL1,STRAP,STUB1,TBC1D1,TGFBR1,TGFBRAP1,TGIF1,TGM2,TNNT1,TOB1,TP53,TP73,TRIM62,TSC2,UBA52,UBR5,UNKL,ZEB1,ZEB2,ZFYVE9,ZMYND11,ZNF41,ZNF8,ZNHIT6,ACVR1B,AKT1,ANAPC10,Arhgef1,Arhgef6,Arhgef7,Arl4d,BRCA2,CAMK2G,CAV1,CDC16,CDC27,CTNNB1,Cdc40,DAB2,DVL1,EID2,EP300,ERBB2IP,ESR1,FOXH1,Fbxo3,HDAC1,HIPK2,INSR,Irak2,JUN,LEF1,Lhx9,Lmo2,MEF2A,MEF2C,MYC,Map2k3,NEDD9,NFYC,Nuak2,PARD3B,PIAS3,PIAS4,PIN1,PML,Ppp2r2d,RNF111,RUNX1,RUNX2,RUNX3,Rab34,Rab38,Rasd2,Rgs3,Rhebl1,Rhobtb1,Rhod,Rhoj,Rps27a,SKI,SKIL,SMAD3,SMAD4,SMAD6,SMAD7,SMURF2,SNIP1,SNW1,SP1,STRAP,Sip1,Smad2,Smad3,Sqstm1,TGFBR1,TGIF1,Trim35,Uhmk1,Wwp2,ZEB1,ZFYVE9
Protein Size: 467 - Molecular Weight
- 52 kDa
- Gene ID
- 4087
- NCBI Accession
- NM_005901, NP_005892
- UniProt
- Q15796
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