Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) Peptide
STAT6
Reactivity: Human
Host: Synthetic
BP, WB, IHC
-
- Target See all STAT6 products
- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
- Origin
- Human
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-STAT6 antibody (Catalog #: ARP31048_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
- Synonyms
- D12S1644 Peptide, IL-4-STAT Peptide, STAT6B Peptide, STAT6C Peptide, signal transducer and activator of transcription 6 Peptide, signal transducer and activator of transcription 6-like Peptide, STAT6 Peptide, Stat6 Peptide, LOC100859543 Peptide
- Background
-
Full-length human STAR6 (NP_003144) was expressed in E.coli as inclusion body and purified after protein refolding for mouse immunization. Clone 5B1 shows excellent western blot detection of endogenous STAT6 using ACHN cell lysate.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: D12S1644, IL-4-STAT, STAT6B, STAT6C
Protein Interaction Partner: IL4R,NMI,STAT6,CEBPB,CREBBP,EP300,ETS1,HIST2H3C,IL4R,IRF4,JAK1,NCOA1,NFKB1,NMI,PRKCZ,PTPN6,RELA,SND1,SRC,STAT2,STAT6,ANXA2,CREBBP,EP300,IRF4,NCOA1,NFKB1,SND1,TP53
Protein Size: 847 - Molecular Weight
- 94 kDa
- Gene ID
- 6778
- NCBI Accession
- NM_003153, NP_003144
- UniProt
- P42226
-
You are here:
