TAR DNA Binding Protein (TARDBP) (Middle Region) Peptide
TARDBP
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all TARDBP products
- TARDBP (TAR DNA Binding Protein (TARDBP))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TARDBP antibody (Catalog #: ARP35837_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TARDBP (TAR DNA Binding Protein (TARDBP))
- Synonyms
- TARDBP Peptide, TDP43 Peptide, DKFZp459I2127 Peptide, tardbp Peptide, ALS10 Peptide, TDP-43 Peptide, 1190002A23Rik Peptide, C85084 Peptide, Tdp43 Peptide, wu:fb77f02 Peptide, wu:fc52g10 Peptide, TAR DNA binding protein Peptide, Tardbp protein Peptide, TAR DNA binding protein L homeolog Peptide, TAR DNA-binding protein 43-like Peptide, TARDBP Peptide, tardbp Peptide, tardbp.L Peptide, Tardbp Peptide, LOC100621383 Peptide
- Background
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HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription.HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: TDP-43, ALS10
Protein Interaction Partner: EXOSC10,NSFL1C,SETDB1,XRN2,ZHX1,EXOSC10,HNRNPA1,KHDRBS2,NSFL1C,SETDB1,UBC,XRN2,ZHX1
Protein Size: 414 - Molecular Weight
- 45 kDa
- Gene ID
- 23435
- NCBI Accession
- NM_007375, NP_031401
- UniProt
- Q13148
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