TNF Receptor-Associated Factor 6 (TRAF6) (Middle Region) Peptide
TRAF6
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all TRAF6 products
- TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TRAF6 antibody (Catalog #: ARP30226_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))
- Synonyms
- MGC:3310 Peptide, RNF85 Peptide, 2310003F17Rik Peptide, AI851288 Peptide, C630032O20Rik Peptide, rnf85 Peptide, traf6 Peptide, xtraf6 Peptide, CG10961 Peptide, DTRAF2 Peptide, Dmel\\CG10961 Peptide, TRAF Peptide, TRAF2 Peptide, TRAF6 Peptide, Traf2 Peptide, dTRAF2 Peptide, dTRAF6 Peptide, dTraf2 Peptide, dtraf2 Peptide, GB10539 Peptide, fi15f02 Peptide, wu:fi15f02 Peptide, zgc:63704 Peptide, TNF receptor associated factor 6 Peptide, TNF receptor-associated factor 6 Peptide, TNF receptor associated factor 6 L homeolog Peptide, TNF-receptor-associated factor 6 Peptide, TNF receptor associated factor 6 S homeolog Peptide, TRAF6 Peptide, Traf6 Peptide, traf6.L Peptide, traf6 Peptide, LOC551819 Peptide, traf6.S Peptide
- Background
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TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein.The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.
Alias Symbols: MGC:3310, RNF85
Protein Interaction Partner: IRAK1,IRAK2,IRAK3,IRF7,MALT1,MAP3K14,TAB3,TICAM1,TICAM1,TICAM2,TRAF6,UBB,UBB,ZFAND5,ABL1,ATP6V1E1,CAV1,CBL,CD40,CYLD,ECSIT,EDA2R,FHL2,HSPA4,IL17RB,IRAK1,IRAK2,IRAK3,IRAK4,IRF5,IRF7,IRF8,KCNQ1,MALT1,MAP2K1,MAP2K6,MAP2K7,MAP3K14,MAP3K3,MAP3K5,MAP3K7,MAP3K8,MAPK14,MAPK8,MAST2,MAVS,MBP,NGFR,NGFRAP1,OTUD7B,PELI3,PRKCZ,PSMB5,PSMC1,PSMC2,PSMC3,PSMD1,PSMD12,PSMD13,PSMD6,PSMD7,PTPN6,RIPK2,SIGIRR,SPHK1,SQSTM1,SRC,STRADB,SYK,TAB1,TAB2,TAB3,TAX1BP1,TDP2,TICAM1,TICAM2,TIFA,TIRAP,TLR3,TMEM189-UBE2V1,TNFAIP3,TNFRSF11A,TNFRSF13B,TNFRSF19,TNFSF11,TRAF2,TRAF3IP2,TRAF4,TRAF6,TRAF7,TRAFD1,TRAM1,TRIM37,UBB,UBE2N,USP7,XIAP,ZFAND5,ZMYND11,ZNF675,ZRANB1,ASXL2,BMPR1B,CD40,CTPS,DDX3X,EDA2R,EIF4E2,EPPK1,Ecsit,FHL2,GANAB,HSPB2,IARS,IKBKG,IL17RA,IRAK1,IRAK2,IRAK3,IRAK4,KCNQ1,MAP3K14,MAP3K5,MAP3K7,MAST2,MCM7,MTHFD1,MYD88,Map3k7,NASP,NGFR,NTRK1,NTRK2,OTUD7B,PAICS,PELI3,PFAS,PPP4C,PRKCZ,PSEN1,PSMB5,PSMC1,PSMC2,PSMC3,PSMD1,PSMD12,PSMD13,PSMD3,PSMD7,RIPK2,RUNX1,SDCBP,SIGIRR,SPOP,SQSTM1,SRC,STRADB,SYK,TAB1,TAB2,TAB3,TARS,TAX1BP1,TDP2,TGFBR1,TIFA,TIRAP,TJP2,TNFAIP3,TNFRSF11A,TNFRSF13B,TRAF2,TRAF3IP1,TRAF6,TRIM37,UBC,UBE2N,UBE2V1,USP7,VARS,VCP,VDAC1,XIAP,ZFAND5,ZMYND11,ZNF675,ZRANB1
Protein Size: 522 - Molecular Weight
- 59 kDa
- Gene ID
- 7189
- NCBI Accession
- NM_004620, NP_004611
- UniProt
- Q9Y4K3
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