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Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (N-Term) Peptide

UBA3 Reactivity: Human Host: Synthetic BP, IHC, WB
Catalog No. ABIN985798
  • Target See all UBA3 products
    UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
    Protein Region
    N-Term
    Origin
    Human
    Source
    • 1
    Synthetic
    Application
    Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-UBA3 antibody (Catalog #: ARP50493_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
    Synonyms
    UBE1C Peptide, hUBA3 Peptide, Ube1c Peptide, ube1c Peptide, wu:fb75e04 Peptide, wu:fc37b11 Peptide, zgc:55528 Peptide, A830034N06Rik Peptide, AI256736 Peptide, AI848246 Peptide, AW546539 Peptide, ubiquitin like modifier activating enzyme 3 Peptide, ubiquitin-like modifier activating enzyme 3 Peptide, ubiquitin like modifier activating enzyme 3 S homeolog Peptide, UBA3 Peptide, Uba3 Peptide, uba3 Peptide, uba3.S Peptide
    Background
    UBA3 is a catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. UBA3 down-regulates steroid receptor activity. UBA3 is necessary for cell cycle progression.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

    Alias Symbols: DKFZp566J164, MGC22384, UBE1C, hUBA3

    Protein Interaction Partner: NAE1,CHD3,NAE1,NEDD8,UBE2M,CHD3,NAE1,NEDD8,UBE2M,UIMC1

    Protein Size: 463
    Molecular Weight
    52 kDa
    Gene ID
    9039
    NCBI Accession
    NM_003968, NP_003959
    UniProt
    Q8TBC4
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