Wingless-Type MMTV Integration Site Family, Member 3 (WNT3) (Middle Region) Peptide

Details for Product No. ABIN986218, Supplier: Log in to see
Protein Name
  • Ci-Wnt3
  • WNT3
  • int4
  • Xwnt3
  • wnt-3
  • wnt3l
  • Xwnt-3
  • wnt3
  • Int-4
  • Wnt-3
  • INT4
  • wnt3-A
  • wingless-type MMTV integration site family, member 3
  • wingless-related MMTV integration site 3
  • WNT3
  • wnt3
  • Wnt3
Protein Region
Middle Region
Origin
Human
1
1
1
1
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Blocked Antibody anti-WNT3 antibody (Wingless-Type MMTV Integration Site Family, Member 3) (Middle Region) (ABIN2783983)
Sequence SHHKGPPGEG WKWGGCSEDA DFGVLVSREF ADARENRPDA RSAMNKHNNE
Characteristics This is a synthetic peptide designed for use in combination with anti-WNT3 Antibody(ARP49956_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98 % amino acid identity to mouse Wnt3 protein, and 84 % to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.

Alias Symbols: INT4, MGC131950, MGC138321, MGC138323

Protein Interaction Partner: FZD1

Protein Size: 355
Molecular Weight 37 kDa
Gene ID 7473
NCBI Accession NM_030753, NP_110380
UniProt P56703
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.