Browse our AANAT Proteins (AANAT)

Full name:
Aralkylamine N-Acetyltransferase Proteins (AANAT)
On are 10 Aralkylamine N-Acetyltransferase (AANAT) Proteins from 4 different suppliers available. Additionally we are shipping AANAT Antibodies (71) and AANAT Kits (31) and many more products for this protein. A total of 115 AANAT products are currently listed.
AA-NAT, DSPS, Nat-2, Nat4, Snat
list all proteins Gene Name GeneID UniProt
AANAT 15 Q16613
AANAT 25120 Q64666
AANAT 11298 O88816

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AANAT Proteins (AANAT) by Origin

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Human Aralkylamine N-Acetyltransferase (AANAT) interaction partners

  1. Data show that arylalkymine N-acetyltransferase (AANAT) levels and melatonin synthesis change after transient receptor potential channel 4 (show TRPC4 Proteins) (TRPV4 (show TRPV4 Proteins) channel) stimulation in ciliary body epithelial cells.

  2. There is dysregulation of the AANAT/ASMT (show ASMT Proteins)/melatonin --> melatonin receptor axis in cholangiocarcinoma, which inhibited melatonin secretion and subsequently enhanced CCA (show FBN2 Proteins) growth.

  3. The expression of AANAT in epithelial cells of striated (show NSDHL Proteins) ducts in human submandibular glands.

  4. The functional expression of human SNA (show SNAI1 Proteins) protein was closely associated with the elevated synthesis of N-acetylserotonin and melatonin in transgenic rice plants.

  5. Identified 17 sequence changes in AANAT gene of patients with major depression. Show evidence of the association of genetic variability in the AANAT gene with susceptibility to major depression.

  6. There is a significant increase in AANAT allele positivity at the single nucleotide polymorphism (alanine 129--> threonine) at between patients with DSPS & controls. AA-NAT could be a susceptibility gene for DSPS.

  7. Data suggest that the -263G/C single nucleotide polymorphism of arylalkylamine-N-acetyl-transferase (AA-NAT) may be an important determinant of the late/short sleep pattern.

  8. Single nucleotide polymorphisms in the AANAT gene identified thus far cannot explain the observed interindividual differences for nocturnal melatonin profiles in the subjects investigated.

  9. AANAT polymorphisms were not associated with adolescent idiopathic scoliosis.

Mouse (Murine) Aralkylamine N-Acetyltransferase (AANAT) interaction partners

  1. Inducing nighttime expression of Aanat facilitates nocturnal melatonin synthesis

  2. AANAT expression and synthesis of N-acetylserotonin/melatonin could play a role in addictive properties of cocaine

  3. analysis of regulation of AANAT gene expression in rats and Syrian hamsters [review]

AANAT Protein Profile

Protein Summary

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with AANAT

  • aralkylamine N-acetyltransferase (AANAT)
  • aralkylamine N-acetyltransferase (Aanat)
  • arylalkylamine N-acetyltransferase (Aanat)
  • arylalkylamine N-acetyltransferase (AANAT)
  • AA-NAT protein
  • DSPS protein
  • Nat-2 protein
  • Nat4 protein
  • Snat protein

Protein level used designations for AANAT

arylalkylamine N-acetyltransferase , serotonin N-acetyltransferase , serotonin acetylase , Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase) , Seretonin N-acetyltransferase , arylakylamine N-acetyltransferase , AA-NAT , pineal serotonin N-acetyltransferase , pineal arylalkylamine N-acetyltransferase , aralkylamine N-acetyltransferase

15 Homo sapiens
25120 Rattus norvegicus
483331 Canis lupus familiaris
396066 Gallus gallus
443531 Ovis aries
706924 Macaca mulatta
503504 Pan troglodytes
11298 Mus musculus
281583 Bos taurus
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