Browse our AKT Proteins (AKT1)

Full name:
V-Akt Murine Thymoma Viral Oncogene Homolog 1 Proteins (AKT1)
On www.antibodies-online.com are 50 V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) Proteins from 17 different suppliers available. Additionally we are shipping AKT Antibodies (1284) and AKT Kits (59) and many more products for this protein. A total of 1492 AKT products are currently listed.
Synonyms:
akt, akt-1, Akt/PKB, akt1, ATAKT1, CG4006, CWS6, D-Akt, dakt, dAKT/dPKB, dAkt/PKB, dakt1, DAKT1/PKB, Dmel\\CG4006, dPKB, DRAC-PK, DRAC-PK66, DRAC-PK85, F18A8.2, F18A8_2, K+ transporter 1, l(3)04226, l(3)89Bq, p-Akt, pAkt, PKB, PKB-ALPHA, PKB/Akt, PKB/dAKT, PKBalpha, POTASSIUM TRANSPORTER, PRKBA, Rac, RAC-ALPHA, RacPK, v-akt, v-akt1, xAct
list all proteins Gene Name GeneID UniProt
AKT1 11651 P31750
AKT1 207 P31749
AKT1 24185 P47196

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AKT Proteins (AKT1) by Origin

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Top referenced AKT Proteins

  1. Human AKT Protein expressed in Baculovirus infected Insect Cells - ABIN2003361 : Coffer, Woodgett: Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. in European journal of biochemistry / FEBS 1991 (PubMed)
    Show all 4 references for 2003361

  2. Human AKT Protein expressed in HEK-293 Cells - ABIN2180576 : Youngson, Jones: Management of the impalpable testis: long-term results of the preperitoneal approach. in Journal of pediatric surgery 1991 (PubMed)
    Show all 4 references for 2180576

More Proteins for AKT Interaction Partners

Fruit Fly (Drosophila melanogaster) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. The metabolic defects of cycG (show CCNG1 Proteins) mutant animals are abrogated by a concomitant loss of Wdb, CycG (show CCNG1 Proteins) presumably influences Akt1 activity at the PP2A (show PPP2R2B Proteins) nexus; Well rounded (Wrd), another B' subunit of PP2A (show PPP2R2B Proteins) in Drosophila, binds CycG (show CCNG1 Proteins) similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG (show CCNG1 Proteins) mutants.

  2. Our findings demonstrated that lovastatin restored LRRK2 (show LRRK2 Proteins)-G2019S neurite degeneration by augmenting Akt/NRF2 (show NFE2L2 Proteins) pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2 (show LRRK2 Proteins)-G2019S parkinsonism.

  3. subtle manipulation of foxo through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.

  4. The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones

  5. these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation

  6. AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.

  7. Akt1 governs two critical elements of synapse development, neurotransmitter receptor (show GRIN1 Proteins) localization, and postsynaptic membrane elaboration

  8. Tsc2 mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 mutants, leading to the hypothesis that Tsc2 and Akt might work via the same genetic pathway to regulate synapse growth.

  9. Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.

  10. Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.

Arabidopsis thaliana V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.

  2. results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (show FNTA Proteins), which further represses the activity of K(+) channel (show KCNC4 Proteins) AKT1 in Arabidopsis.

  3. Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.

  4. AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.

  5. These findings provide further insights into the signaling network consisting of CBL (show CBL Proteins)-CIPK-PP2C interactions in the activation of the AKT1 channel.

  6. Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.

  7. AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.

  8. In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.

  9. CIPK23 directly phosphorylates the K+ transporter AKT1

  10. Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (show CA2 Proteins)+)-dependent manner, connecting the Ca(2 (show CA2 Proteins)+) signal to K(+) uptake through activation of a K(+) channel (show KCNC4 Proteins).

Mouse (Murine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. TSC1 (show TSC1 Proteins)/TSC2 complex upregulation of OPN (show SPP1 Proteins) expression is mediated by transcription factor SOX9 (show SOX9 Proteins) in an mTOR (show FRAP1 Proteins)-independent manner. Moreover, ablation of OPN (show SPP1 Proteins) by deficient TSC1 (show TSC1 Proteins)/TSC2 complex contributed to inactivation of AKT in TSC (show SLC12A3 Proteins) cells

  2. Our results suggest that increasing Akt/ NF-kappaB (show NFKB1 Proteins) is a crucial mediator of skin aging, which can increase the susceptibility of cell transformation.

  3. findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis.

  4. Studies indicate that the Pten+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten is a key regulatory player in the PI3K/PTEN/AKT pathway.

  5. a simple, linear, four-compartment ordinary differential equation (ODE) model of Akt activation that tracks both the biochemical state and the physical location of Akt, is reported.

  6. Psgl-1 (show SELPLG Proteins) deficiency accelerates bleomycin-induced lung fibrosis and inflammation in mice through activating the PI3K/AKT axis.

  7. Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (show HSP90 Proteins) and the PI3K/AKT/mTOR (show FRAP1 Proteins) pathway in prostate cancer.

  8. Furthermore, Leishmania RNA virus 1-induced TLR-3 (show TLR3 Proteins) activation promoted parasite persistence by enhancing macrophage survival through Akt activation in a manner partially dependent on miR (show MLXIP Proteins)-155.

  9. Collectively, these findings showed that SA suppressed mammary gland development of pubertal mice, which was coincident with the SA-inhibited HC11 proliferation, and was associated with inhibition of PI3K/Akt signaling pathway through activation of GPR120.

  10. Findings suggest that atorvastatin attenuates diabetes-associated renal injury by reducing reactive oxygen species (ROS) generation, RhoA activity and normalizing Akt/GSK3beta signaling pathways.

Human V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. High AKT1 expression is associated with melanoma.

  2. PTEN rs701848 and AKT1 rs2494752 polymorphisms might be a candidate pharmacogenomic factor to assess the susceptibility of and response and prognosis prediction for interindividualized CE(A)F chemotherapy in breast cancer patients.

  3. Lysophosphatidylcholine activates the Akt pathway to upregulate extracellular matrix protein production in human aortic valve cells and may contribute to the mechanism of valvular sclerosis associated with the development and progression of aortic stenosis.

  4. Cross-talk between Akt1 and Src (show SRC Proteins) regulates endothelial-barrier function.

  5. We found statistically significant DNA hypomethylation of the promoter regions of DRD3 (show DRD3 Proteins) (P = 0.032), DRD4 (show DRD4 Proteins) (P = 0.05), MB-COMT (show COMT Proteins) (P = 0.009), and AKT1 (P = 0.0008) associated with increased expression of the corresponding genes in patients with methamphetamine psychosis (P = 0.022, P = 0.034, P = 0.035, P = 0.038, respectively)

  6. High AKT1 expression is associated with T-cell leukemia.

  7. Results indicate that p110alpha (show PIK3CA Proteins) primarily mediates PI3K (show PIK3CA Proteins)/AKT signaling in HER2 (show ERBB2 Proteins)+ PTEN deficient breast tumors whereas p110beta conditionally mediates HER2 (show ERBB2 Proteins)/PI3K (show PIK3CA Proteins) signaling in the absence of p110alpha (show PIK3CA Proteins).

  8. AKT1 mutation is associated with olfactory groove meningiomas.

  9. Activation of stromal MYC (show MYC Proteins) was critical for this reprogramming and for the sustained cellular responses elicited by LO, both in vitro and in vivo in an AKT1-dependent manner. Inhibition of LO internalization prevented activation of MYC (show MYC Proteins) and impaired the tumor-supporting properties of fibroblasts.

  10. Cytokines IL-2 (show IL2 Proteins)/7/9 stimulation activates PI3K (show PIK3CA Proteins)/Akt pathways downstream of Ras in RasGRP1 (show RASGRP1 Proteins) T-cell acute lymphoblastic leukemia (T-ALL).

Pig (Porcine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.

  2. Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.

  3. In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.

  4. In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.

  5. Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.

  6. Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.

  7. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  8. findings show that megalin (show LRP2 Proteins) is the sensor that determines whether cells will be protected or injured by albumin (show ALB Proteins); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [

  9. protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea

  10. Akt signaling in porcine patellofemoral joint cartilage is dependent upon frequency of loading, cartilage zone, and the time interval between loading and cartilage harvest.

Cow (Bovine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (show CTNNB1 Proteins) accumulation and subsequent ovarian E2 production.

  2. Caveolin-1 (show CAV1 Proteins) scaffolding domain residue phenylalanine 92 modulates Akt signaling

  3. TG2 (show TGM2 Proteins) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.

  4. results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta, and NF-kappaB (show NFKB1 Proteins).

  5. The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (show NOX1 Proteins), reactive oxygen species, and PI3-kinase (show PIK3CA Proteins) in stimulated NO release.

  6. PI3K/Akt and p53 (show TP53 Proteins) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  7. Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

  8. Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (show NOS3 Proteins) activation in endothelial cells

  9. Losartan metabolite stimulates eNOS (show NOS3 Proteins) phosphorylation and suppresses tumor necrosis factor alpha (show TNF Proteins)-induced endothelial cell apoptosis by activating AKT1.

  10. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (show FRAP1 Proteins) and ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins) signaling in an AKT-independent manner

AKT (AKT1) Protein Profile

Protein Summary

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with AKT (AKT1)

  • v-akt murine thymoma viral oncogene homolog 1 (AKT1)
  • v-akt murine thymoma viral oncogene homolog 1 (akt1)
  • CG4006 gene product from transcript CG4006-RA (Akt1)
  • potassium channel AKT1 (KT1)
  • thymoma viral proto-oncogene 1 (Akt1)
  • v-akt murine thymoma viral oncogene homolog 1 (Akt1)
  • akt protein
  • akt-1 protein
  • Akt/PKB protein
  • akt1 protein
  • ATAKT1 protein
  • CG4006 protein
  • CWS6 protein
  • D-Akt protein
  • dakt protein
  • dAKT/dPKB protein
  • dAkt/PKB protein
  • dakt1 protein
  • DAKT1/PKB protein
  • Dmel\\CG4006 protein
  • dPKB protein
  • DRAC-PK protein
  • DRAC-PK66 protein
  • DRAC-PK85 protein
  • F18A8.2 protein
  • F18A8_2 protein
  • K+ transporter 1 protein
  • l(3)04226 protein
  • l(3)89Bq protein
  • p-Akt protein
  • pAkt protein
  • PKB protein
  • PKB-ALPHA protein
  • PKB/Akt protein
  • PKB/dAKT protein
  • PKBalpha protein
  • POTASSIUM TRANSPORTER protein
  • PRKBA protein
  • Rac protein
  • RAC-ALPHA protein
  • RacPK protein
  • v-akt protein
  • v-akt1 protein
  • xAct protein

Protein level used designations for AKT1

RAC-alpha serine/threonine-protein kinase , protein kinase B , v-akt murine thymoma viral oncogene homolog 1 , Akt kinase , Akt1-PA , Akt1-PB , Akt1-PC , CG4006-PA , CG4006-PB , CG4006-PC , dAkt kinase , related to PKA to PKC protein kinases , related to the A and C kinases , AKT1 kinase , PKB alpha , RAC-PK-alpha , protein kinase B alpha , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , proto-oncogene c-Akt , rac protein kinase alpha , RAC protein kinase alpha RAC-PK alpha , murine thymoma viral (v-akt) oncogene homolog 1 , thymoma viral proto-oncogene 1 , Akt , protein kinase Akt-1 , protein kinase B, alpha , xAkt , serine/threonine protein kinase , v-akt murine thymoma viral oncogene-like 1 , v-akt murine thymoma viral oncogene-like protein 1

GENE ID SPECIES
100294652 Ovis aries
697747 Macaca mulatta
740898 Pan troglodytes
100101714 Xenopus (Silurana) tropicalis
100490038 Xenopus (Silurana) tropicalis
41957 Drosophila melanogaster
100556289 Anolis carolinensis
100587109 Nomascus leucogenys
817206 Arabidopsis thaliana
11651 Mus musculus
207 Homo sapiens
24185 Rattus norvegicus
399170 Xenopus laevis
395928 Gallus gallus
490878 Canis lupus familiaris
100126861 Sus scrofa
280991 Bos taurus
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