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Browse our AKT Proteins (AKT1)

Full name:
V-Akt Murine Thymoma Viral Oncogene Homolog 1 Proteins (AKT1)
On www.antibodies-online.com are 37 V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) Proteins from 17 different suppliers available. Additionally we are shipping AKT Antibodies (1198) and AKT Kits (49) and many more products for this protein. A total of 1385 AKT products are currently listed.
Synonyms:
akt, akt-1, Akt/PKB, akt1, ATAKT1, CG4006, CWS6, D-Akt, dakt, dAKT/dPKB, dAkt/PKB, dakt1, DAKT1/PKB, Dmel\\CG4006, dPKB, DRAC-PK, DRAC-PK66, DRAC-PK85, F18A8.2, F18A8_2, K+ transporter 1, l(3)04226, l(3)89Bq, p-Akt, pAkt, PKB, PKB-ALPHA, PKB/Akt, PKB/dAKT, PKBalpha, POTASSIUM TRANSPORTER, PRKBA, Rac, RAC-ALPHA, RacPK, v-akt, v-akt1, xAct
list all proteins Gene Name GeneID UniProt
AKT1 11651 P31750
AKT1 207 P31749
AKT1 24185 P47196

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AKT Proteins (AKT1) by Origin

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Top referenced AKT Proteins

  1. Human AKT Protein expressed in Baculovirus infected Insect Cells - ABIN2003361 : Coffer, Woodgett: Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. in European journal of biochemistry / FEBS 1991 (PubMed)
    Show all 4 references for ABIN2003361

  2. Human AKT Protein expressed in HEK-293 Cells - ABIN2180576 : Youngson, Jones: Management of the impalpable testis: long-term results of the preperitoneal approach. in Journal of pediatric surgery 1991 (PubMed)
    Show all 4 references for ABIN2180576

More Proteins for AKT Interaction Partners

Fruit Fly (Drosophila melanogaster) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. subtle manipulation of foxo through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.

  2. The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones

  3. these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation

  4. AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.

  5. Akt1 governs two critical elements of synapse development, neurotransmitter receptor (show GRIN1 Proteins) localization, and postsynaptic membrane elaboration

  6. Tsc2 mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 mutants, leading to the hypothesis that Tsc2 and Akt might work via the same genetic pathway to regulate synapse growth.

  7. Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.

  8. Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.

  9. Overexpression of Akt enhanced Sindbis virus replication.

  10. Perturbation of the Akt/Gsk3-beta signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs.

Arabidopsis thaliana V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (show FNTA Proteins), which further represses the activity of K(+) channel (show KCNC4 Proteins) AKT1 in Arabidopsis.

  2. Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.

  3. AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.

  4. These findings provide further insights into the signaling network consisting of CBL (show CBL Proteins)-CIPK-PP2C interactions in the activation of the AKT1 channel.

  5. Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.

  6. AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.

  7. In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.

  8. CIPK23 directly phosphorylates the K+ transporter AKT1

  9. Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (show CA2 Proteins)+)-dependent manner, connecting the Ca(2 (show CA2 Proteins)+) signal to K(+) uptake through activation of a K(+) channel (show KCNC4 Proteins).

  10. AtAKT1 mediates K+ absorption at high concentrations, and remains active in the presence of NH4+ although activity is reduced.

Mouse (Murine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. Adiponectin (show ADIPOQ Proteins) exerts novel effects to limit the production and action of mono-MPs, underscoring yet another pleiotropic effect of this adipokine.

  2. Endothelial Akt1 activation in ovarian grafts promoted angiogenesis to support the graft during posttransplantation hypoxic period

  3. Uncarboxylated osteocalcin (show BGLAP Proteins) inhibits high glucose-induced reactive oxygen species production and stimulates osteoblastic differentiation by inhibiting the activation of PI3K/Akt in MC3T3-E1 cells.

  4. miR-23b acts as a suppressor of epithelial-to-mesenchymal transition in diabetic nephropathy through repressing PI3K-AKT signaling pathway by targeting HMGA2 and thus alleviating the disease.

  5. PI3K/AKT pathway was partially involved in the modulation of the release HMGB-1 (show HMGB1 Proteins) from reactive astrocytes.

  6. These observations suggest that the antiinflammatory properties of crebanine may stem from the inhibition of proinflammatory mediators via suppression of the NF-kappaB (show NFKB1 Proteins), AP-1 (show JUN Proteins), MAPKs, and Akt signaling pathways.

  7. Data show that RNA silencing of CCN family member 1 (show CYR61 Proteins) protein (CCN1 (show CCNA2 Proteins)) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT protein signaling in mouse pup model of oxygen-induced retinopathy (OIR).

  8. rescued the hepatic regenerative capability in Akt1-deficient and Akt2 (show AKT2 Proteins)-deficient mice

  9. While combined Akt1 and Akt3 deletion in adult mice is tolerated, combined Akt1 and Akt2 deletion induced rapid mortality involving glucose metabolism problems. ACT1-null mice are not resistant to diethylnitrosamine hepatocarcinogenesis.

  10. ShRNA knockdown (kd) of AKT1 prevents phosphorylation and subsequent degradation of nuclear lamins.

Human V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. we discovered a novel mechanism mediated by Smad4 (show SMAD4 Proteins) to trigger 5-FU chemosensitivity through cell cycle arrest by inhibiting the PI3K (show PIK3CA Proteins)/Akt/CDC2 (show CDK1 Proteins)/survivin (show BIRC5 Proteins) cascade.

  2. The underlying mechanisms involve reduced phosphorylation of Akt and nuclear factor-kappaB (NF-kappaB (show NFKB1 Proteins)) p65 (show GORASP1 Proteins). We noted that as with EtP, EtOH reduced the inflammatory response in lung epithelial cells under acute inflammatory conditions

  3. The transcription activity of PI3K (show PIK3CA Proteins)/AKT was markedly inhibited by CA, as well as IGF-1 (show IGF1 Proteins) which functions as an anti-apoptotic factor

  4. our results indicate that miR (show MLXIP Proteins)-181A expression is associated with CRC (show CALR Proteins) patients with late liver metastases through PTEN/AKT signaling.

  5. By inhibiting mTOR (show FRAP1 Proteins) and MnSOD (show SOD2 Proteins), we confirmed that rapamycin functioned through the mTOR (show FRAP1 Proteins)/MnSOD (show SOD2 Proteins)/reactive oxygen species (ROS (show ROS1 Proteins)) signaling pathway, and the existence of Akt governed the rapamycininduced asymmetric division

  6. in a high number of HNSCC tumours, PI3K (show PIK3CA Proteins)/Akt signalling is activated by different molecules or by the combination of these molecules.

  7. The AKT1 gene codes for a protein kinase that forms part of the striatal dopamine receptor signalling cascade.

  8. suggest the AKT/SOX2 (show SOX2 Proteins) molecular axis as a regulator of breast carcinoma (BC) clonogenicity and AKT inhibitors as promising drugs for the treatment of SOX2 (show SOX2 Proteins)-positive BC

  9. Thus, GWL is a human oncoprotein that promotes the hyperactivation of AKT via the degradation of its phosphatase, PHLPP, in human malignancies.

  10. Our study demonstrates that the IGF1R (show IGF1R Proteins)/p110b/AKT/mTOR (show FRAP1 Proteins) axis confers resistance to BYL719 in PIK3CA (show PIK3CA Proteins) mutant breast cancers.

Pig (Porcine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.

  2. Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.

  3. Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.

  4. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  5. findings show that megalin (show LRP2 Proteins) is the sensor that determines whether cells will be protected or injured by albumin (show ALB Proteins); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [

  6. protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea

  7. Akt signaling in porcine patellofemoral joint cartilage is dependent upon frequency of loading, cartilage zone, and the time interval between loading and cartilage harvest.

  8. in VSMCs exposed to hyperglycemia, IGF-I (show IGF1 Proteins) stimulation of Shc (show SHC1 Proteins) facilitates the transfer of Grb2 (show GRB2 Proteins) to p85 (show ARHGEF7 Proteins) resulting in enhanced PI3K activation and AKT phosphorylation leading to enhanced cell proliferation and migration

  9. There was no correlation of infarct size with expression or phosphorylation of AKT in ischemic postconditioning.

Cow (Bovine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (show CTNNB1 Proteins) accumulation and subsequent ovarian E2 production.

  2. Caveolin-1 (show CAV1 Proteins) scaffolding domain residue phenylalanine 92 modulates Akt signaling

  3. TG2 (show TGM2 Proteins) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.

  4. results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta, and NF-kappaB (show NFKB1 Proteins).

  5. The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (show NOX1 Proteins), reactive oxygen species, and PI3-kinase (show PIK3CA Proteins) in stimulated NO release.

  6. PI3K/Akt and p53 (show TP53 Proteins) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  7. Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

  8. Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (show NOS3 Proteins) activation in endothelial cells

  9. Losartan metabolite stimulates eNOS (show NOS3 Proteins) phosphorylation and suppresses tumor necrosis factor alpha (show TNF Proteins)-induced endothelial cell apoptosis by activating AKT1.

  10. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (show FRAP1 Proteins) and ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins) signaling in an AKT-independent manner

AKT (AKT1) Protein Profile

Protein Summary

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with AKT (AKT1)

  • v-akt murine thymoma viral oncogene homolog 1 (AKT1)
  • v-akt murine thymoma viral oncogene homolog 1 (akt1)
  • CG4006 gene product from transcript CG4006-RA (Akt1)
  • potassium channel AKT1 (KT1)
  • thymoma viral proto-oncogene 1 (Akt1)
  • v-akt murine thymoma viral oncogene homolog 1 (Akt1)
  • akt protein
  • akt-1 protein
  • Akt/PKB protein
  • akt1 protein
  • ATAKT1 protein
  • CG4006 protein
  • CWS6 protein
  • D-Akt protein
  • dakt protein
  • dAKT/dPKB protein
  • dAkt/PKB protein
  • dakt1 protein
  • DAKT1/PKB protein
  • Dmel\\CG4006 protein
  • dPKB protein
  • DRAC-PK protein
  • DRAC-PK66 protein
  • DRAC-PK85 protein
  • F18A8.2 protein
  • F18A8_2 protein
  • K+ transporter 1 protein
  • l(3)04226 protein
  • l(3)89Bq protein
  • p-Akt protein
  • pAkt protein
  • PKB protein
  • PKB-ALPHA protein
  • PKB/Akt protein
  • PKB/dAKT protein
  • PKBalpha protein
  • POTASSIUM TRANSPORTER protein
  • PRKBA protein
  • Rac protein
  • RAC-ALPHA protein
  • RacPK protein
  • v-akt protein
  • v-akt1 protein
  • xAct protein

Protein level used designations for AKT1

RAC-alpha serine/threonine-protein kinase , protein kinase B , v-akt murine thymoma viral oncogene homolog 1 , Akt kinase , Akt1-PA , Akt1-PB , Akt1-PC , CG4006-PA , CG4006-PB , CG4006-PC , dAkt kinase , related to PKA to PKC protein kinases , related to the A and C kinases , AKT1 kinase , PKB alpha , RAC-PK-alpha , protein kinase B alpha , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , proto-oncogene c-Akt , rac protein kinase alpha , RAC protein kinase alpha RAC-PK alpha , murine thymoma viral (v-akt) oncogene homolog 1 , thymoma viral proto-oncogene 1 , Akt , protein kinase Akt-1 , protein kinase B, alpha , xAkt , serine/threonine protein kinase , v-akt murine thymoma viral oncogene-like 1 , v-akt murine thymoma viral oncogene-like protein 1

GENE ID SPECIES
100294652 Ovis aries
697747 Macaca mulatta
740898 Pan troglodytes
100101714 Xenopus (Silurana) tropicalis
100490038 Xenopus (Silurana) tropicalis
41957 Drosophila melanogaster
100556289 Anolis carolinensis
100587109 Nomascus leucogenys
817206 Arabidopsis thaliana
11651 Mus musculus
207 Homo sapiens
24185 Rattus norvegicus
399170 Xenopus laevis
395928 Gallus gallus
490878 Canis lupus familiaris
100126861 Sus scrofa
280991 Bos taurus
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