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Browse our AKT Proteins (AKT1)

Full name:
V-Akt Murine Thymoma Viral Oncogene Homolog 1 Proteins (AKT1)
On www.antibodies-online.com are 37 V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) Proteins from 17 different suppliers available. Additionally we are shipping AKT Antibodies (1250) and AKT Kits (47) and many more products for this protein. A total of 1433 AKT products are currently listed.
Synonyms:
akt, akt-1, Akt/PKB, akt1, ATAKT1, CG4006, CWS6, D-Akt, dakt, dAKT/dPKB, dAkt/PKB, dakt1, DAKT1/PKB, Dmel\\CG4006, dPKB, DRAC-PK, DRAC-PK66, DRAC-PK85, F18A8.2, F18A8_2, K+ transporter 1, l(3)04226, l(3)89Bq, p-Akt, pAkt, PKB, PKB-ALPHA, PKB/Akt, PKB/dAKT, PKBalpha, POTASSIUM TRANSPORTER, PRKBA, Rac, RAC-ALPHA, RacPK, v-akt, v-akt1, xAct
list all proteins Gene Name GeneID UniProt
AKT1 11651 P31750
AKT1 207 P31749
AKT1 24185 P47196

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AKT Proteins (AKT1) by Origin

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Top referenced AKT Proteins

  1. Human AKT Protein expressed in Baculovirus infected Insect Cells - ABIN2003361 : Coffer, Woodgett: Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. in European journal of biochemistry / FEBS 1991 (PubMed)
    Show all 4 references for ABIN2003361

  2. Human AKT Protein expressed in HEK-293 Cells - ABIN2180576 : Youngson, Jones: Management of the impalpable testis: long-term results of the preperitoneal approach. in Journal of pediatric surgery 1991 (PubMed)
    Show all 4 references for ABIN2180576

More Proteins for AKT Interaction Partners

Fruit Fly (Drosophila melanogaster) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. subtle manipulation of foxo through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.

  2. The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones

  3. these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation

  4. AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.

  5. Akt1 governs two critical elements of synapse development, neurotransmitter receptor (show GRIN1 Proteins) localization, and postsynaptic membrane elaboration

  6. Tsc2 mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 mutants, leading to the hypothesis that Tsc2 and Akt might work via the same genetic pathway to regulate synapse growth.

  7. Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.

  8. Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.

  9. Overexpression of Akt enhanced Sindbis virus replication.

  10. Perturbation of the Akt/Gsk3-beta signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs.

Arabidopsis thaliana V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (show FNTA Proteins), which further represses the activity of K(+) channel (show KCNC4 Proteins) AKT1 in Arabidopsis.

  2. Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.

  3. AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.

  4. These findings provide further insights into the signaling network consisting of CBL (show CBL Proteins)-CIPK-PP2C interactions in the activation of the AKT1 channel.

  5. Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.

  6. AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.

  7. In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.

  8. CIPK23 directly phosphorylates the K+ transporter AKT1

  9. Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (show CA2 Proteins)+)-dependent manner, connecting the Ca(2 (show CA2 Proteins)+) signal to K(+) uptake through activation of a K(+) channel (show KCNC4 Proteins).

  10. AtAKT1 mediates K+ absorption at high concentrations, and remains active in the presence of NH4+ although activity is reduced.

Mouse (Murine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. Results suggest a role of ST6GalNAc I (show ST6GALNAC1 Proteins) in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT/NF-kappa B (show NFKB1 Proteins) signaling, and ST6GalNAc I (show ST6GALNAC1 Proteins) might be a marker for the prognosis and therapy of hepatocarcinoma.

  2. The data indicate that the balanced activities of two related serine/threonine kinases, AKT and SGK1 (show SGK1 Proteins), critically govern the embryo implantation process.

  3. These results suggest that DDI may improve insulin (show INS Proteins) sensitivity through the activation of Akt signaling, which leads to enhanced glucose uptake.

  4. observations revealed that the alteration of PKB-GSK-3beta axis, Plk-1, and Aurora kinase-A expressions in HSPC compartment due to DNA damage response was associated with the proliferative impairment and apoptosis during aplastic anemia.

  5. A20 (show TNFAIP3 Proteins) reduces lipid storage and inflammation in hypertrophic adipocytes via p38 (show CRK Proteins) and Akt signaling.

  6. the mTORC2 (show CRTC2 Proteins)/Akt/NFkappaB pathway-mediated activation of TRPC6 (show TRPC6 Proteins) participates in adriamycin-induced podocyte apoptosis.

  7. Ambient fine particulate matter-induced myocarditis is mediated by EGFR (show EGFR Proteins)/Akt signaling and overexpression of NLRP3 (show NLRP3 Proteins) and NLRP12 (show NLRP12 Proteins).

  8. GSK3b may up-regulate BK channels, an effect disrupted by lithium or additional expression of AKT and possibly participating in the regulation of cell volume and excitability.

  9. Akt1 regulates cell division and F-actin rearrangement in mouse fertilized eggs.

  10. The results suggest that KCa3.1 (show KCNN4 Proteins) activation contributes to dysfunctional tubular autophagy in diabetic nephropathy through PI3K/Akt/mTOR (show FRAP1 Proteins) signaling pathways.

Human V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. Inhibition of protooncogenic microRNA-181a may suppress proliferation and invasion and promote apoptosis of cervical cancer cells through the PTEN/Akt/FOXO1 (show FOXO1 Proteins) pathway.

  2. the potentially functional AKT1 rs2494752 SNP may affect Gastric Adenocarcinoma susceptibility, likely by modulating the AKT1 promoter transcriptional activity

  3. our results highlight that the Nox1 (show NOX1 Proteins)/AKT signaling pathway plays an important role in cell survival in oral squamous cell carcinoma (OSCC) cells.

  4. Phosphorylation level of Akt declined from 138.45+/-13.8 to 69.9+/-29.7% in SGC (show SGCB Proteins)-7901, and from 115.5+/-26.6 to 49.07+/-27% in MGC-803 and phosphorylation level of mTOR (show FRAP1 Proteins) also significantly decreased.While apoptosis of gastric cancer(GA) cells increased which we verified with apoptosis proteins and staining analysis. Our data showed that RLIP76 (show RALBP1 Proteins) plays a significant oncogenic role in GC and it maybe a potential target in GC

  5. Our study suggested that CXCR7 plays an important proangiogenic role in hepatocellular carcinoma (HCC (show FAM126A Proteins)). via activation of the AKT pathway. So CXCR7 may be a potential target for antiangiogenic therapy in HCC (show FAM126A Proteins)

  6. Findings demonstrate a new role of microRNA 185 as a key regulator of hepatocellular carcinoma via autophagy by dysregulation of AKT1 pathway.

  7. the phosphorylation levels of ErbB2 (show ERBB2 Proteins), ErbB3 (show ERBB3 Proteins) and Akt and the protein levels of cyclin D1 (show CCND1 Proteins) were decreased by lapatinib treatment of HSC3, HSC4 and Ca9 (show CA9 Proteins)-22 cells

  8. enhanced NEK2 (show NEK2 Proteins) expression in hepatocellular carcinoma (HCC (show FAM126A Proteins)) promotes HCC (show FAM126A Proteins) progression and drug resistance by promoting PP1 (show PPA1 Proteins)/Akt and Wnt (show WNT2 Proteins) pathway activation, which may represent a new therapeutic target for HCC (show FAM126A Proteins).

  9. Our results demonstrated that NC inhibits development of glioblastoma multiforme (GBM) by targeting the PI3K (show PIK3CA Proteins)/Akt/mTOR (show FRAP1 Proteins) signaling pathway and provides a potential therapeutic agent for the treatment of GBM.

  10. The authors found that Akt interacts with HIV-1 Nef protein. In primary T cells treated with exogenous Nef or acutely infected with Nef-expressing HIV-1 in vitro, Akt became phosphorylated on serine(473) and threonine(308).

Pig (Porcine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.

  2. In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.

  3. Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.

  4. Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.

  5. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  6. findings show that megalin (show LRP2 Proteins) is the sensor that determines whether cells will be protected or injured by albumin (show ALB Proteins); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [

  7. protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea

  8. Akt signaling in porcine patellofemoral joint cartilage is dependent upon frequency of loading, cartilage zone, and the time interval between loading and cartilage harvest.

  9. in VSMCs exposed to hyperglycemia, IGF-I (show IGF1 Proteins) stimulation of Shc (show SHC1 Proteins) facilitates the transfer of Grb2 (show GRB2 Proteins) to p85 (show ARHGEF7 Proteins) resulting in enhanced PI3K activation and AKT phosphorylation leading to enhanced cell proliferation and migration

  10. There was no correlation of infarct size with expression or phosphorylation of AKT in ischemic postconditioning.

Cow (Bovine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

  1. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (show CTNNB1 Proteins) accumulation and subsequent ovarian E2 production.

  2. Caveolin-1 (show CAV1 Proteins) scaffolding domain residue phenylalanine 92 modulates Akt signaling

  3. TG2 (show TGM2 Proteins) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.

  4. results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta, and NF-kappaB (show NFKB1 Proteins).

  5. The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (show NOX1 Proteins), reactive oxygen species, and PI3-kinase (show PIK3CA Proteins) in stimulated NO release.

  6. PI3K/Akt and p53 (show TP53 Proteins) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  7. Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

  8. Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (show NOS3 Proteins) activation in endothelial cells

  9. Losartan metabolite stimulates eNOS (show NOS3 Proteins) phosphorylation and suppresses tumor necrosis factor alpha (show TNF Proteins)-induced endothelial cell apoptosis by activating AKT1.

  10. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (show FRAP1 Proteins) and ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins) signaling in an AKT-independent manner

AKT (AKT1) Protein Profile

Protein Summary

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with AKT (AKT1)

  • v-akt murine thymoma viral oncogene homolog 1 (AKT1)
  • v-akt murine thymoma viral oncogene homolog 1 (akt1)
  • CG4006 gene product from transcript CG4006-RA (Akt1)
  • potassium channel AKT1 (KT1)
  • thymoma viral proto-oncogene 1 (Akt1)
  • v-akt murine thymoma viral oncogene homolog 1 (Akt1)
  • akt protein
  • akt-1 protein
  • Akt/PKB protein
  • akt1 protein
  • ATAKT1 protein
  • CG4006 protein
  • CWS6 protein
  • D-Akt protein
  • dakt protein
  • dAKT/dPKB protein
  • dAkt/PKB protein
  • dakt1 protein
  • DAKT1/PKB protein
  • Dmel\\CG4006 protein
  • dPKB protein
  • DRAC-PK protein
  • DRAC-PK66 protein
  • DRAC-PK85 protein
  • F18A8.2 protein
  • F18A8_2 protein
  • K+ transporter 1 protein
  • l(3)04226 protein
  • l(3)89Bq protein
  • p-Akt protein
  • pAkt protein
  • PKB protein
  • PKB-ALPHA protein
  • PKB/Akt protein
  • PKB/dAKT protein
  • PKBalpha protein
  • POTASSIUM TRANSPORTER protein
  • PRKBA protein
  • Rac protein
  • RAC-ALPHA protein
  • RacPK protein
  • v-akt protein
  • v-akt1 protein
  • xAct protein

Protein level used designations for AKT1

RAC-alpha serine/threonine-protein kinase , protein kinase B , v-akt murine thymoma viral oncogene homolog 1 , Akt kinase , Akt1-PA , Akt1-PB , Akt1-PC , CG4006-PA , CG4006-PB , CG4006-PC , dAkt kinase , related to PKA to PKC protein kinases , related to the A and C kinases , AKT1 kinase , PKB alpha , RAC-PK-alpha , protein kinase B alpha , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , proto-oncogene c-Akt , rac protein kinase alpha , RAC protein kinase alpha RAC-PK alpha , murine thymoma viral (v-akt) oncogene homolog 1 , thymoma viral proto-oncogene 1 , Akt , protein kinase Akt-1 , protein kinase B, alpha , xAkt , serine/threonine protein kinase , v-akt murine thymoma viral oncogene-like 1 , v-akt murine thymoma viral oncogene-like protein 1

GENE ID SPECIES
100294652 Ovis aries
697747 Macaca mulatta
740898 Pan troglodytes
100101714 Xenopus (Silurana) tropicalis
100490038 Xenopus (Silurana) tropicalis
41957 Drosophila melanogaster
100556289 Anolis carolinensis
100587109 Nomascus leucogenys
817206 Arabidopsis thaliana
11651 Mus musculus
207 Homo sapiens
24185 Rattus norvegicus
399170 Xenopus laevis
395928 Gallus gallus
490878 Canis lupus familiaris
100126861 Sus scrofa
280991 Bos taurus
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