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these results demonstrate the effective anti-autophagic of NRAGE (show MAGED1 ELISA Kits) in non-small-cell lung cancer cells through AMPK (show PRKAA1 ELISA Kits)/Ulk1 (show ULK1 ELISA Kits)/Atg13 autophagy signaling pathways. Therefore, NRAGE (show MAGED1 ELISA Kits) could be used as a potential therapeutic target for lung cancer.
These results show that the SiMoA technology can detect quantitatively low levels of endogenous biomarkers with the ability to detect the loss of pSer(318)-Atg13 upon ULK1 (show ULK1 ELISA Kits) inhibition.
Structure of the human Atg13-Atg101 (show C12orf44 ELISA Kits) HORMA heterodimer in the ULK1 (show ULK1 ELISA Kits) complex that controls autophagy has been described.
Specific affinity of the LC3 (show MAP1LC3A ELISA Kits) isoforms to the Atg13 LC3 (show MAP1LC3A ELISA Kits)-interacting region is required for proper autophagosome formation.
In response to DNA damage, ULK1 (show ULK1 ELISA Kits) and ULK2 (show ULK2 ELISA Kits) are upregulated by p53 (show TP53 ELISA Kits). The upregulation of ULK1 (show ULK1 ELISA Kits) (ULK2 (show ULK2 ELISA Kits))/ATG13 complex by p53 (show TP53 ELISA Kits) is necessary for the sustained autophagy activity induced by DNA damage.
The gene product is the functional homologue of yeast Atg13, and required for autophagy in mammalian cells.
mTORC1 suppresses autophagy through direct regulation of the approximately 3-MDa ULK1 (show ULK1 ELISA Kits)-Atg13-FIP200 (show RB1CC1 ELISA Kits) complex.
The ULK-Atg13-FIP200 (show RB1CC1 ELISA Kits) complexes are direct targets of mTOR (show FRAP1 ELISA Kits) and important regulators of autophagy in response to mTOR (show FRAP1 ELISA Kits) signaling.
ATG13 and ULK1 (show ULK1 ELISA Kits) are phosphorylated by the mTOR (show FRAP1 ELISA Kits) pathway in a nutrient starvation-regulated manner, indicating that the ULK1 (show ULK1 ELISA Kits).ATG13.FIP200 (show RB1CC1 ELISA Kits) complex acts as a node for integrating incoming autophagy signals into autophagosome biogenesis.
The identification of the novel protein, Atg101 (show C12orf44 ELISA Kits), and the validation of Atg13 and Atg101 (show C12orf44 ELISA Kits) as ULK1 (show ULK1 ELISA Kits)-interacting proteins, suggests an Atg1 (show ULK1 ELISA Kits) complex is involved in the induction of macroautophagy in mammalian cells.
ATG13 phosphorylation plays a crucial role in autophagy regulation.
autophagy can be executed by mechanisms that are dependent or independent of the ULK1 (show ULK1 ELISA Kits)/2-ATG13 interaction.
Atg13-deficient embryos show growth retardation and myocardial growth defects.
Autophagy factor required for autophagosome formation (By similarity). Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex (By similarity).
ATG13 autophagy related 13 homolog
, autophagy-related protein 13
, harbinger transposase derived 1
, hypothetical protein