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|Application / Reactivity||Human|
|Biochemical Assay (BCA)||1 Antibodies|
|BioImaging (BI)||2 Antibodies|
|Dot Blot (DB)||11 Antibodies|
|Enzyme Immunoassay (EIA)||8 Antibodies|
|Flow Cytometry (FACS)||30 Antibodies|
|Immunochromatography (IC)||3 Antibodies|
|Immunocytochemistry (ICC)||7 Antibodies|
|Immunofluorescence (IF)||40 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||33 Antibodies|
|Immunohistochemistry (IHC)||66 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||1 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||4 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||40 Antibodies|
|Immunoprecipitation (IP)||34 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|RNA Interference (RNAi)||1 Antibodies|
|Antigen||Cyclin-Dependent Kinase 2 (CDK2) Antibodies|
|Epitope||AA 230-260, C-Term Alternatives|
|Conjugate||This CDK2 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-CDK2 AntibodyTarget Details CDK2 Application Details Handling References for anti-CDK2 Antibody (ABIN391746) Images
|Specificity||This CDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238~267 amino acids from the C-terminal region of human CDK2.|
|Predicted Reactivity||Cow (Bovine),Hamster,Mouse (Murine),Rat (Rattus),Xenopus laevis|
|Purification||This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Immunogen||This CDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-260 AA from the C-terminal region of human CDK2.|
Target Details CDK2Product Details anti-CDK2 Antibody Application Details Handling References for anti-CDK2 Antibody (ABIN391746) Images back to top
|Alternative Name||CDK2 (CDK2 Antibody Abstract)|
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation.
Synonyms: Cell division protein kinase 2, p33 protein kinase
|Molecular Weight||33929 DA|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure|
|Pathways||PI3K-Akt Signaling, Cell Division Cycle|
Application DetailsProduct Details anti-CDK2 Antibody Target Details CDK2 Handling References for anti-CDK2 Antibody (ABIN391746) Images back to top
|Application Notes||WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50|
|Restrictions||For Research Use only|
HandlingProduct Details anti-CDK2 Antibody Target Details CDK2 Application Details References for anti-CDK2 Antibody (ABIN391746) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.|
|Expiry Date||6 months|
References for anti-CDK2 Antibody (ABIN391746)Product Details anti-CDK2 Antibody Target Details CDK2 Application Details Handling Images back to top
ONions, Allday: "Epstein-Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2." in: Oncogene, Vol. 22, Issue 46, pp. 7181-91, 2003 (PubMed).
Moshinsky, Bellamacina, Boisvert et al.: "SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 1026-31, 2003 (PubMed).
Izumiya, Lin, Ellison et al.: "Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest." in: Journal of virology, Vol. 77, Issue 17, pp. 9652-61, 2003 (PubMed).
Chow, Siu, Ho et al.: "Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 40815-28, 2003 (PubMed).
Yun, Chae, Choi et al.: "Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36966-72, 2003 (PubMed).
ImagesProduct Details anti-CDK2 Antibody Target Details CDK2 Application Details Handling References for anti-CDK2 Antibody (ABIN391746) back to top