Browse our Cyclin A Proteins (CCNA2)

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Cyclin A2 Proteins (CCNA2)
On are 14 Cyclin A2 (CCNA2) Proteins from 6 different suppliers available. Additionally we are shipping Cyclin A Antibodies (229) and Cyclin A Kits (1) and many more products for this protein. A total of 252 Cyclin A products are currently listed.
AA408589, cb671, Ccn-1, Ccn1, Ccna, ccna1, ccna2, chunp6924, CYCA, CycA2, Cyclin-A, Cyclin-A2, cyclinA, wu:fi36f03
list all proteins Gene Name GeneID UniProt
CCNA2 890 P20248
CCNA2 12428 P51943
Rat CCNA2 CCNA2 114494  

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Cyclin A Proteins (CCNA2) by Origin

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Top referenced Cyclin A Proteins

  1. Human Cyclin A Protein expressed in Escherichia coli (E. coli) - ABIN1098299 : Alvarez-Fernández, Halim, Aprelia, Laoukili, Mohammed, Medema: Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation. in The Journal of biological chemistry 2011 (PubMed)
    Show all 2 references for 1098299

  2. Human Cyclin A Protein expressed in Wheat germ - ABIN1348430 : Touati, Cladière, Lister, Leontiou, Chambon, Rattani, Böttger, Stemmann, Nasmyth, Herbert, Wassmann: Cyclin A2 is required for sister chromatid segregation, but not separase control, in mouse oocyte meiosis. in Cell reports 2012 (PubMed)

More Proteins for Cyclin A Interaction Partners

Human Cyclin A2 (CCNA2) interaction partners

  1. Low CCNA expression is associated with lung cancer progression.

  2. cyclin D1 (show CCND1 Proteins) and other cyclins such as cyclin A regulates DNA integrity through RAD51 (show RAD51 Proteins) interaction with the BRCA2 (show BRCA2 Proteins) C-terminal domain

  3. inhibition of PDK4 (show PDK4 Proteins) activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Proteins), cyclin A2, and E2F1 (show E2F1 Proteins) proteins.

  4. An increase of cyclin A2 expression was identified for the first time in a case of splenic diffuse red pulp small B-cell lymphoma.

  5. Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 (show CDK2 Proteins) or Cyclin A2 knockdown. These findings support G2 exit as the more significant effect of Wee1 (show WEE1 Proteins) inhibition in pancreatic cancers.

  6. Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21 (show CDKN1A Proteins), p27 (show PAK2 Proteins)-cyclin E (show CCNE1 Proteins),A/Cdk2 (show CDK2 Proteins) pathway.

  7. On analyzing cyclin A and B1 (CCNA and CCNB1 (show CCNB1 Proteins)) expression, positive staining in 90% cases of PTC (show F9 Proteins) were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC (show F9 Proteins).

  8. Study describes a positive feedback loop centred on cyclin A2-Cdk2 (show CDK2 Proteins) inhibition of interphase APC (show APC Proteins)/C-Cdc20 (show CDC20 Proteins) to allow further cyclin A2 accumulation and mitotic entry.

  9. PIWIL2 has a role in promoting progression of non-small cell lung cancer by inducing CDK2 (show CDK2 Proteins) and Cyclin A expression

  10. Cyclin A2-binding function of pUL21a contributes to the maintenance of a cell cycle state conducive for the completion of the human cytomegalovirus (HCMV) replication cycle.

Mouse (Murine) Cyclin A2 (CCNA2) interaction partners

  1. These data unveils the critical functions of cyclin A2 in regulating mammalian erythropoiesis.

  2. Meioc-deficient spermatocytes that have initiated synapsis mis (show AMH Proteins)-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program.

  3. inhibition of PDK4 (show PDK4 Proteins) activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Proteins), cyclin A2, and E2F1 (show E2F1 Proteins) proteins.

  4. cyclin A2 controlled Mre11 (show MRE11A Proteins) abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 (show MRE11A Proteins) transcripts to mediate polysome loading and translation.

  5. hese data suggest that mmu-miR (show MLXIP Proteins)-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K (show EEF2K Proteins) and CCNA2 expression.

  6. Cyclin A2 modulates epithelial-mesenchymal transition via beta-catenin (show CTNNB1 Proteins) and phospholipase C (show PLC Proteins) pathways.

  7. Ccn2 (show CTGF Proteins) is a regulator of the transition through cytokinesis during terminal erythropoiesis.

  8. Loss of CCNA2 decreases cell proliferation and induces cerebellar cortical dyslamination.

  9. Data indicate that cyclin A2-depleted epithelial cells adopt a fibroblastic morphology and undergo epithelial to mesenchymal transition (EMT (show ITK Proteins)).

  10. The activity of PCTK3 (show CDK18 Proteins) is increased via interaction with cyclin A2 and phosphorylation by PKA.

Cow (Bovine) Cyclin A2 (CCNA2) interaction partners

  1. B-Myb (show MYBL2 Proteins) represses SMC (show DYM Proteins) elastin (show ELN Proteins) gene expression and cyclin A plays a role in the developmental regulation of elastin (show ELN Proteins) gene expression in the aorta

  2. inconstant elongation of the poly(A) tail was observed for cyclin A2 transcripts after maturation

Zebrafish Cyclin A2 (CCNA2) interaction partners

  1. an essential role for UHRF1 (show UHRF1 Proteins) phosphorylation by cyclin-dependent kinase 2 (show CDK2 Proteins)/cyclin A2 during early vertebrate development

Cyclin A (CCNA2) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.

Alternative names and synonyms associated with Cyclin A (CCNA2)

  • cyclin A2 (ccna2)
  • cyclin A2 (CCNA2)
  • cyclin A (LOC100352785)
  • cyclin A2 (Ccna2)
  • cyclin A2 (LOC397933)
  • AA408589 protein
  • cb671 protein
  • Ccn-1 protein
  • Ccn1 protein
  • Ccna protein
  • ccna1 protein
  • ccna2 protein
  • chunp6924 protein
  • CYCA protein
  • CycA2 protein
  • Cyclin-A protein
  • Cyclin-A2 protein
  • cyclinA protein
  • wu:fi36f03 protein

Protein level used designations for Cyclin A2 Proteins (CCNA2)

cyclin A1 , cyclin A , cyclin A2 , cyclin-A2-like , cyclin-A , cyclin-A2 , Cyclin A2 (Cyclin A)

448454 Xenopus (Silurana) tropicalis
461467 Pan troglodytes
100388293 Callithrix jacchus
100453784 Pongo abelii
100352785 Oryctolagus cuniculus
890 Homo sapiens
12428 Mus musculus
114494 Rattus norvegicus
281667 Bos taurus
734775 Xenopus laevis
192295 Danio rerio
396172 Gallus gallus
483845 Canis lupus familiaris
100415929 Sus scrofa
397933 Xenopus laevis
101835930 Mesocricetus auratus
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