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Human Cyclin A Protein expressed in Wheat germ - ABIN1348430
Touati, Cladière, Lister, Leontiou, Chambon, Rattani, Böttger, Stemmann, Nasmyth, Herbert, Wassmann: Cyclin A2 is required for sister chromatid segregation, but not separase control, in mouse oocyte meiosis. in Cell reports 2012
Low CCNA expression is associated with lung cancer progression.
cyclin D1 (show CCND1 Proteins) and other cyclins such as cyclin A regulates DNA integrity through RAD51 (show RAD51 Proteins) interaction with the BRCA2 (show BRCA2 Proteins) C-terminal domain
inhibition of PDK4 (show PDK4 Proteins) activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Proteins), cyclin A2, and E2F1 (show E2F1 Proteins) proteins.
An increase of cyclin A2 expression was identified for the first time in a case of splenic diffuse red pulp small B-cell lymphoma.
Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 (show CDK2 Proteins) or Cyclin A2 knockdown. These findings support G2 exit as the more significant effect of Wee1 (show WEE1 Proteins) inhibition in pancreatic cancers.
Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21 (show CDKN1A Proteins), p27 (show PAK2 Proteins)-cyclin E (show CCNE1 Proteins),A/Cdk2 (show CDK2 Proteins) pathway.
On analyzing cyclin A and B1 (CCNA and CCNB1 (show CCNB1 Proteins)) expression, positive staining in 90% cases of PTC (show F9 Proteins) were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC (show F9 Proteins).
Study describes a positive feedback loop centred on cyclin A2-Cdk2 (show CDK2 Proteins) inhibition of interphase APC (show APC Proteins)/C-Cdc20 (show CDC20 Proteins) to allow further cyclin A2 accumulation and mitotic entry.
PIWIL2 has a role in promoting progression of non-small cell lung cancer by inducing CDK2 (show CDK2 Proteins) and Cyclin A expression
Cyclin A2-binding function of pUL21a contributes to the maintenance of a cell cycle state conducive for the completion of the human cytomegalovirus (HCMV) replication cycle.
We demonstrate that CCNA2-null progenitors suffer abnormal DNA repair, and implicate Cyclin A2 in double-strand break repair. Cyclin A2's DNA repair functions are conserved among cell lines, neural progenitors, and hippocampal neurons. We further demonstrate that neuronal CCNA2 ablation results in learning and memory deficits in aged mice.
Cyclin A2 binds to Mre11 (show MRE11A Proteins) mRNA to promote Mre11 (show MRE11A Proteins) translation and repair of replication errors.
cyclin A2 mediates the fidelity ofmeiosis II by maintaining microtubule dynamics during the rapid formation of the meiosis II spindle.
These data unveils the critical functions of cyclin A2 in regulating mammalian erythropoiesis.
Meioc-deficient spermatocytes that have initiated synapsis mis (show AMH Proteins)-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program.
cyclin A2 controlled Mre11 (show MRE11A Proteins) abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 (show MRE11A Proteins) transcripts to mediate polysome loading and translation.
hese data suggest that mmu-miR (show MLXIP Proteins)-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K (show EEF2K Proteins) and CCNA2 expression.
Cyclin A2 modulates epithelial-mesenchymal transition via beta-catenin (show CTNNB1 Proteins) and phospholipase C (show PLC Proteins) pathways.
Ccn2 (show CTGF Proteins) is a regulator of the transition through cytokinesis during terminal erythropoiesis.
B-Myb (show MYBL2 Proteins) represses SMC (show DYM Proteins) elastin (show ELN Proteins) gene expression and cyclin A plays a role in the developmental regulation of elastin (show ELN Proteins) gene expression in the aorta
inconstant elongation of the poly(A) tail was observed for cyclin A2 transcripts after maturation
an essential role for UHRF1 (show UHRF1 Proteins) phosphorylation by cyclin-dependent kinase 2 (show CDK2 Proteins)/cyclin A2 during early vertebrate development
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
, cyclin A
, cyclin A2
, Cyclin A2 (Cyclin A)