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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)||Goat|
|Western Blotting (WB)||290 Antibodies||109 Antibodies||100 Antibodies||3 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Intracellular Staining (ICS)||1 Antibodies||1 Antibodies||1 Antibodies|
|Immunoprecipitation (IP)||67 Antibodies||24 Antibodies||24 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||65 Antibodies||20 Antibodies||18 Antibodies||3 Antibodies|
|Immunohistochemistry (IHC)||84 Antibodies||45 Antibodies||44 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||26 Antibodies|
|Antigen||Cyclin D1 (CCND1) Antibodies|
|Epitope||AA 70-120 Alternatives|
|Reactivity||Goat, Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Cyclin D1 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|12 references available|
|Supplier||Log in to see|
Product Details anti-Cyclin D1 AntibodyTarget Details Cyclin D1 Application Details Handling References for anti-Cyclin D1 Antibody (ABIN671016) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from mouse Cyclin D1|
Target Details Cyclin D1Product Details anti-Cyclin D1 Antibody Application Details Handling References for anti-Cyclin D1 Antibody (ABIN671016) Images back to top
|Alternative Name||Cyclin D1 (CCND1 Antibody Abstract)|
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity).
Subcellular location: Cytoplasm, Nucleus
Synonyms: cD1, CycD1, Cyl-1, PRAD1, bcl-1, AI32739, G1/S-specific cyclin-D1, Ccnd1
|Research Area||Cancer, Cell Cycle|
|Pathways||PI3K-Akt Signaling, Cell Division Cycle|
Application DetailsProduct Details anti-Cyclin D1 Antibody Target Details Cyclin D1 Handling References for anti-Cyclin D1 Antibody (ABIN671016) Images back to top
|Application Notes||WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)|
|Restrictions||For Research Use only|
HandlingProduct Details anti-Cyclin D1 Antibody Target Details Cyclin D1 Application Details References for anti-Cyclin D1 Antibody (ABIN671016) Images back to top
|Buffer||Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-Cyclin D1 Antibody (ABIN671016)Product Details anti-Cyclin D1 Antibody Target Details Cyclin D1 Application Details Handling Images back to top
|Product cited in:||
Yang, Wang, Hui et al.: "SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/β-catenin pathway." in: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015 (PubMed).
Zhang, Pan, Xu et al.: "Interleukin 18 augments growth ability via NF-?B and p38/ATF2 pathways by targeting cyclin B1, cyclin B2, cyclin A2, and Bcl-2 in BRL-3A rat liver cells." in: Gene, Vol. 563, Issue 1, pp. 45-51, 2015 (PubMed).
He, Xiang, Zong et al.: "CDK2-AP1 inhibits growth of breast cancer cells by regulating cell cycle and increasing docetaxel sensitivity in vivo and in vitro." in: Cancer cell international, Vol. 14, Issue 1, pp. 130, 2014 (PubMed).
Wang, Yang, Liu et al.: "RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway." in: Biochemical and biophysical research communications, Vol. 454, Issue 1, pp. 71-7, 2015 (PubMed).
Lin, Wang, Wang et al.: "Lithocarpus polystachyus REHD leaf aqueous extract inhibits human breast cancer growth in vitro and in vivo." in: Nutrition and cancer, Vol. 66, Issue 4, pp. 613-24, 2014 (PubMed).
Shi, Lu, Zhou et al.: "Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells." in: Biochemical and biophysical research communications, Vol. 446, Issue 2, pp. 448-53, 2014 (PubMed).
Ye, Li, Li et al.: "Anti-tumor activity and relative mechanism of ethanolic extract of Marsdenia tenacissima (Asclepiadaceae) against human hematologic neoplasm in vitro and in vivo." in: Journal of ethnopharmacology, Vol. 153, Issue 1, pp. 258-67, 2014 (PubMed).
Zhang, Tan, Wang et al.: "Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway." in: Experimental cell research, Vol. 320, Issue 1, pp. 119-27, 2013 (PubMed).
Wang, Wu, Gao et al.: "Elevated toll-like receptor 3 inhibits pancreatic ?-cell proliferation through G1 phase cell cycle arrest." in: Molecular and cellular endocrinology, Vol. 377, Issue 1-2, pp. 112-22, 2013 (PubMed).
Teng, Chang, Wang et al.: "Phospholipid-functionalized mesoporous silica nanocarriers for selective photodynamic therapy of cancer." in: Biomaterials, Vol. 34, Issue 30, pp. 7462-70, 2013 (PubMed).
Li, Yu, Liu et al.: "miR-34c works downstream of p53 leading to dairy goat male germline stem-cell (mGSCs) apoptosis." in: Cell proliferation, Vol. 46, Issue 2, pp. 223-31, 2013 (PubMed). (1:1000).
Chen, Shi, Liu et al.: "Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis." in: BMC cancer, Vol. 12, pp. 464, 2012 (PubMed). (1:1000).
ImagesProduct Details anti-Cyclin D1 Antibody Target Details Cyclin D1 Application Details Handling References for anti-Cyclin D1 Antibody (ABIN671016) back to top