anti-Human FOXO1 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended FOXO1 Antibody (supplied by: Log in to see )

Antigen
Forkhead Box O1 (FOXO1) Antibodies
  • FOXO1
  • FOXO1A
  • fkh1
  • fkhr
  • foxo1a
  • xFoxO1
  • FKH1
  • FKHR
  • AI876417
  • Afxh
  • Fkhr1
  • Foxo1a
  • Fkhr
  • FoxO1A
  • FoxO1a.1
  • foxo1
  • zgc:153388
  • forkhead box O1
  • forkhead box O1 a
  • FOXO1
  • foxo1
  • Foxo1
  • foxo1a
Epitope
AA 315-325, pSer319
54
35
32
27
22
19
18
17
16
10
10
9
8
8
5
5
5
5
4
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
470
253
201
35
29
21
14
12
8
7
5
3
3
3
3
2
2
1
1
Host
Rabbit
320
134
21
2
Clonality
Polyclonal
Conjugate
This FOXO1 antibody is un-conjugated
11
11
9
8
8
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
2
2
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
381
207
135
134
131
83
55
12
9
9
5
4
4
4
3
3
2
1
Options
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Catalog No. ABIN684733
$ 329.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.5717 ABIN4312363 ICC IF IHC IHC (p) Rabbit IgG Log in to see Polyclonal 2
11.5717 ABIN250693 ICC IF IHC IHC (p) IP PLA WB Rabbit IgG C-Term Log in to see Polyclonal 8
11.5717 ABIN498785 IHC (p) WB Rabbit pSer256 Log in to see Polyclonal
11.5717 ABIN498702 IF IHC (p) WB Rabbit pSer319 Log in to see Polyclonal
11.5717 ABIN498701 IF IHC (p) WB Rabbit pSer256 Log in to see Polyclonal
11.5717 ABIN498786 IHC (p) WB Rabbit pSer319 Log in to see Polyclonal
11.5717 ABIN615498 IHC (p) Goat C-Term Log in to see Polyclonal
11.5717 ABIN498199 IF IHC (p) WB Rabbit Log in to see Polyclonal
11.5717 ABIN498580 IF IHC (p) WB Rabbit Log in to see Polyclonal
11.5717 ABIN498876 IHC (p) WB Rabbit Log in to see Polyclonal
11.5717 ABIN498877 IHC (p) WB Rabbit Log in to see Polyclonal
11.5717 ABIN4312364 ELISA ICC IF IHC IHC (p) WB Mouse IgG1 Log in to see 3B6
11.5717 ABIN784062 EIA IF IHC (p) WB Rabbit IgG N-Term Log in to see Polyclonal
11.5717 ABIN152351 ICC IF IHC (p) IHC WB Mouse IgG1 Log in to see 7H3
11.5717 ABIN4312371 FACS ICC IF IHC IHC (p) SimWes WB Mouse IgG2b kappa Log in to see 83N7F8
11.5717 ABIN407936 IHC (p) IHC Rabbit IgG N-Term Log in to see Polyclonal
11.5717 ABIN5557370 IF (cc) IHC (p) WB Rabbit IgG Log in to see 3G1
1 ABIN390584 IHC (p) WB Rabbit Ig AA 454-482, Asp469, Center Log in to see Polyclonal 2
1 ABIN197334 IF IHC (p) WB Rabbit AA 254-258 Log in to see Polyclonal 5
1 ABIN196848 IF IHC (p) WB Rabbit pSer319 Log in to see Polyclonal 3

General

Antigen Forkhead Box O1 (FOXO1) Antibodies
Epitope AA 315-325, pSer319
(54), (35), (32), (27), (22), (19), (18), (17), (16), (10), (10), (9), (8), (8), (5), (5), (5), (5), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(470), (253), (201), (35), (29), (21), (14), (12), (8), (7), (5), (3), (3), (3), (3), (2), (2), (1), (1)
Host Rabbit
(320), (134), (21), (2)
Clonality
Polyclonal
Conjugate This FOXO1 antibody is un-conjugated
(11), (11), (9), (8), (8), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(381), (207), (135), (134), (131), (83), (55), (12), (9), (9), (5), (4), (4), (4), (3), (3), (2), (1)
Pubmed 1 reference available
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Product Details anti-FOXO1 Antibody

Target Details FOXO1 Application Details Handling References for anti-FOXO1 antibody (ABIN684733) Images
Specificity This phosphorylation site is found at Ser316 in mouse, Ser313 in rat
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human FoxO1 around the phosphorylation site of Ser319 [TS(p-S)NA]
Isotype IgG

Target Details FOXO1

Product Details anti-FOXO1 Antibody Application Details Handling References for anti-FOXO1 antibody (ABIN684733) Images back to top
Antigen
Alternative Name Foxo1 (FOXO1 Antibody Abstract)
Background

Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.

Subcellular location: Cytoplasm, Nucleus

Synonyms: FKH1, FKHR, FOXO1A, Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, FOXO1

Gene ID 2308
UniProt Q12778
Pathways PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events

Application Details

Product Details anti-FOXO1 Antibody Target Details FOXO1 Handling References for anti-FOXO1 antibody (ABIN684733) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-FOXO1 Antibody Target Details FOXO1 Application Details References for anti-FOXO1 antibody (ABIN684733) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-FOXO1 antibody (ABIN684733)

Product Details anti-FOXO1 Antibody Target Details FOXO1 Application Details Handling Images back to top
Product cited in:

Lowther, Goods, Lucca, Lerner, Raddassi, van Dijk, Hernandez, Duan, Gunel, Coric, Krishnaswamy, Love, Hafler: "PD-1 marks dysfunctional regulatory T cells in malignant gliomas." in: JCI insight, Vol. 1, Issue 5, 2016

Images

Product Details anti-FOXO1 Antibody Target Details FOXO1 Application Details Handling References for anti-FOXO1 antibody (ABIN684733) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Forkhead Box O1 (FOXO1) (AA 315-325), (pSer319) antibody (ABIN684733) Formalin-fixed and paraffin-embedded rat kidney tissue labeled with Rabbit Anti-Phosp...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Forkhead Box O1 (FOXO1) (AA 315-325), (pSer319) antibody (ABIN684733) Formalin-fixed and paraffin embedded rat testis labeled with Rabbit Anti-FoxO1 (Ser31...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Forkhead Box O1 (FOXO1) (AA 315-325), (pSer319) antibody (ABIN684733) Formalin-fixed and paraffin-embedded rat kidney tissue labeled with Rabbit Anti-Phosp...