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|Antigen||Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This GRIA1 antibody is un-conjugated Alternatives|
Dot Blot (DB), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-GRIA1 AntibodyTarget Details GRIA1 Application Details Handling References for anti-GRIA1 antibody (ABIN265100) Images
|Specificity||This antibody reacts to Glutamate Receptor 1 (GluR1) (pSer831).|
|Immunogen||Sythetic peptide corresponding to amino acid residues surrounding the phospho-Ser831 of rat GluR1.|
Target Details GRIA1Product Details anti-GRIA1 Antibody Application Details Handling References for anti-GRIA1 antibody (ABIN265100) Images back to top
|Alternative Name||Glutamate Receptor 1 / GLUR1 (GRIA1 Antibody Abstract)|
|Background||The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990, Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is potentiated by phosphorylation at Ser831 which has been shown to be mediated by either PKC or CAM kinase II (McGlade-Mcculloh et al., 1993, Mammen et al., 1999, Roche et al., 1996). In addition, phosphorylation of this site has been linked to synaptic plasticity as well and learning and memory (Soderling and Derkach, 2000).Synonyms: AMPA-selective glutamate receptor 1, AMPA1, GLUH1, GRIA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor ionotropic|
Application DetailsProduct Details anti-GRIA1 Antibody Target Details GRIA1 Handling References for anti-GRIA1 antibody (ABIN265100) Images back to top
Western Blot: 1: 1000. Dot Blot: 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-GRIA1 Antibody Target Details GRIA1 Application Details References for anti-GRIA1 antibody (ABIN265100) Images back to top
|Buffer||HEPES ( pH 7.5) solution containing 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage Comment||Ship on dry ice. Store (in aliquots) at -20 °C to -70 °C.|
References for anti-GRIA1 antibody (ABIN265100)Product Details anti-GRIA1 Antibody Target Details GRIA1 Application Details Handling Images back to top
Soderling, Derkach: "Postsynaptic protein phosphorylation and LTP." in: Trends in neurosciences, Vol. 23, Issue 2, pp. 75-80, 2000
Roche, OBrien, Mammen, Bernhardt, Huganir: "Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit." in: Neuron, Vol. 16, Issue 6, pp. 1179-88, 1996
Hollmann, Heinemann: "Cloned glutamate receptors." in: Annual review of neuroscience, Vol. 17, pp. 31-108, 1994
McGlade-McCulloh, Yamamoto, Tan, Brickey, Soderling: "Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II." in: Nature, Vol. 362, Issue 6421, pp. 640-2, 1993
Keinänen, Wisden, Sommer, Werner, Herb, Verdoorn, Sakmann, Seeburg: "A family of AMPA-selective glutamate receptors." in: Science (New York, N.Y.), Vol. 249, Issue 4968, pp. 556-60, 1990
ImagesProduct Details anti-GRIA1 Antibody Target Details GRIA1 Application Details Handling References for anti-GRIA1 antibody (ABIN265100) back to top