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anti-Human GRIA2 antibody for Enzyme Immunoassay

Recommended GRIA2 Antibody (supplied by: Log in to see )

Antigen
Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2) Antibodies
  • GluA2
  • Glur-2
  • GluR-2
  • gluR-B
  • GluR-B
  • GluR-K2
  • Glur2
  • GluR2
  • glur2
  • GLUR2
  • GLURB
  • HBGR2
Epitope
C-Term, AA 840-886
50
12
11
9
6
5
4
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
132
100
78
16
11
10
7
4
4
4
1
1
1
Host
Rabbit
138
16
1
Clonality
Polyclonal
Conjugate
This GRIA2 antibody is un-conjugated
4
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
131
41
33
23
11
7
7
7
6
3
3
2
2
1
1
Supplier
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Catalog No. ABIN493016
$ 456.50
Plus shipping costs $45.00

Top referenced anti-GRIA2 antibody for Enzyme Immunoassay

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General

Antigen Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2) Antibodies
Epitope C-Term, AA 840-886
(50), (12), (11), (9), (6), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(132), (100), (78), (16), (11), (10), (7), (4), (4), (4), (1), (1), (1)
Host Rabbit
(138), (16), (1)
Clonality
Polyclonal
Conjugate This GRIA2 antibody is un-conjugated
(4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Western Blotting (WB)
(131), (41), (33), (23), (11), (7), (7), (7), (6), (3), (3), (2), (2), (1), (1)
Pubmed 5 references available
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Product Details anti-GRIA2 Antibody

Target Details GRIA2 Application Details Handling References for anti-GRIA2 Antibody (ABIN493016) Images
Specificity This antibody detects a single band of approximately 106 kDa in GluR2 samples.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Affiinity chromatography
Immunogen Synthetic peptide corresponding to C-term of GluR2 (aa 840-886)

Target Details GRIA2

Product Details anti-GRIA2 Antibody Application Details Handling References for anti-GRIA2 Antibody (ABIN493016) Images back to top
Antigen
Alternative Name Glutamate Receptor 2 / GLUR2 (GRIA2 Antibody Abstract)
Background Ionotropic Glutamate Receptor 2 (GluR2) is a predominant excitatory neurotransmitter in mammalian brain located at human chromosome 4q32-33 (1). It belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors (2). GluR2 plays a crucial role in controlling the calcium permeability of AMPA receptors and therefore, its presence or absence greatly influences AMPA receptor properties and synaptic functions. GluR2 mRNA ordinarily undergoes post-transcriptional editing which is essential for brain function. AMPA receptors containing edited GluR2 have low conductance, low calcium permeability and confer a linear current-voltage (I-V) relationship. AMPA receptors lacking an edited GluR2 subunit have high calcium permeability and also exhibit inward rectifying I-V relationship (3). Defective GluR2 RNA editing might also play a role in the development of amyotrophic lateral sclerosis (ALS) (4). GluR2 is among the most common and abundant receptor in striatum and projection neurons. In rats, all striatal projection neurons express GluR2 (5). It is highly concentrated on the postsynaptic neuronal membranes of the superficial dorsal horn and its removal might contribute to spinal central sensitization in persistent inflammatory pain (6). It is expressed in cortex, hippocampus and cerebellum. It is approximately a 106 kDa protein (886 amino acids).Synonyms: AMPA-selective glutamate receptor 2, AMPA2, GRIA2, GluR-B, GluR-K2, Glutamate receptor ionotropic
Gene ID 2891
NCBI Accession NP_000817
UniProt P42262
Pathways PI3K-Akt Signaling

Application Details

Product Details anti-GRIA2 Antibody Target Details GRIA2 Handling References for anti-GRIA2 Antibody (ABIN493016) Images back to top
Application Notes ELISA: < 1: 10,000. Western blot: > 1: 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-GRIA2 Antibody Target Details GRIA2 Application Details References for anti-GRIA2 Antibody (ABIN493016) Images back to top
Concentration 0.64 - 0.72 mg/mL
Buffer Stabilization buffer
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.

References for anti-GRIA2 Antibody (ABIN493016)

Product Details anti-GRIA2 Antibody Target Details GRIA2 Application Details Handling Images back to top
Background publications

Park, Voitenko, Petralia, Guan, Xu, Steinberg, Takamiya, Sotnik, Kopach, Huganir, Tao: "Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 10, pp. 3206-19, 2009

Deng, Xie, Wang, Lei, Chen, Reiner: "Differential localization of the GluR1 and GluR2 subunits of the AMPA-type glutamate receptor among striatal neuron types in rats." in: Journal of chemical neuroanatomy, Vol. 33, Issue 4, pp. 167-92, 2007

Gryder, Castaneda, Rogawski: "Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala." in: Journal of neurochemistry, Vol. 94, Issue 6, pp. 1728-38, 2005

Kawahara, Ito, Sun, Aizawa, Kanazawa, Kwak: "Glutamate receptors: RNA editing and death of motor neurons." in: Nature, Vol. 427, Issue 6977, pp. 801, 2004

Sun, Ferrer-Montiel, Montal: "Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain." in: Neuroreport, Vol. 5, Issue 4, pp. 441-4, 1994