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|Antigen||Glycogen Synthase Kinase 3 alpha (GSK3a) Antibodies|
|Reactivity||Chicken, Human, Monkey, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This GSK3 alpha antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Product Details anti-GSK3 alpha AntibodyTarget Details GSK3 alpha Application Details Handling Images
This antibody recognizes GSK-3.
Cellular Localization: Cytoplasmic.
Species reactivity (expected):Mouse, Rat, Monkey, Chicken.
Species reactivity (tested):Human.
Also reacts to: beta
|Immunogen||A synthetic peptide from C-terminus of Human GSK-3.|
Target Details GSK3 alphaProduct Details anti-GSK3 alpha Antibody Application Details Handling Images back to top
|Alternative Name||GSK3 alpha (GSK3a Antibody Abstract)|
|Background||Glycogen Synthase Kinase-3 differs from most serine/threonine kinases in that it is active in the absence of the action of signaling pathways. Two isoforms exist, GSK-3alpha and GSK-3beta. The function of GSK-3 is to phosphorylate glycogen synthase and thereby inactivate it. Insulin action stimulates the PI 3-kinase pathway, resulting in Akt activation, which phosphorylates and inactivates GSK-3.Synonyms: Factor A, GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 alpha|
|Molecular Weight||46-51 kDa|
|Research Area||Atherosclerosis, Cardiovascular, Hypertrophy, Kinases/Phosphatases, Wnt, Wnt Signaling|
|Pathways||PI3K-Akt Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process|
Application DetailsProduct Details anti-GSK3 alpha Antibody Target Details GSK3 alpha Handling Images back to top
Immunohistochemistry on Paraffin Sections: 1/100 for 10 min at RT. Staining offormalin-fixed tissues requires boiling tissue sections in 10 mM citrate, pH 6.0 for 10 minfollowed by cooling at RT for 20 min. Positive Control: Jurkat cells and brain.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-GSK3 alpha Antibody Target Details GSK3 alpha Application Details Images back to top
|Buffer||10 mM PBS, pH 7.4 with 1 % BSA as stabilizer and 0,09 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!|