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demonstrated that GSK-3alpha is regulated by CREB (show CREB1 ELISA Kits) in lung cancer and is required for the cell viability. These findings implicate CREB (show CREB1 ELISA Kits)-GSK-3alpha axis as a novel therapeutic target for lung cancer treatment
GSK3 acts through APC motifs R2 and B to regulate APC:Axin interactions, promoting high-throughput of betacatenin to destruction.
reveals that GSK-3alpha- and GSK-3beta-regulated pathways can be responsible for stepwise transition to myelodysplastic syndromes and subsequent acute myeloid leukemia (show BCL11A ELISA Kits)
CHP3 (show TESC ELISA Kits) functions as a novel negative regulator of cardiomyocyte hypertrophy via inhibition of GSK3alpha/beta phosphorylation.
Elevated GSK3 protein kinase activity is associated with non-small cell lung carcinoma
GSK3A is redundant with GSK3B in regulating drug-resistance and chemotherapy-induced necroptosis
ER stress-PERK-GSK3alpha/beta signaling promotes proatherogenic macrophage lipid accumulation
glycogen synthase kinase 3 alpha and beta activity is increased in foetal membranes after term and preterm labour
TRAIL-induced apoptosis in pancreatic ductal adenocarcinoma cell lines is enhanced by pharmacological inhibition of glycogen synthase kinase-3 (GSK-3) or by shRNA-mediated depletion of either GSK-3alpha or GSK-3beta.
Data indicate that autophagy inhibition promotes glycogen synthase kinase-(GSK3) inhibition-induced apoptosis.
Gsk3 play a role in the maintenance of DNA methylation (show HELLS ELISA Kits) at a majority of the imprinted loci in embryonic stem cells
Sperm GSK3A is essential for male fertility.
The absence of oocyte GSK3 isoforms in the periconceptional period does not alter fertility yet causes offspring cardiac hyperplasia, cardiovascular defects, and significant neonatal death.
results support the model that GSK3 activity status is regulated by the circadian clock and that GSK3 feeds back to regulate the molecular clock amplitude in the suprachiasmatic nucleus
Gsk3-deleted neurons expressing upper layer markers exhibited striking migration failure in all areas of the cortex.
PI3K/AKT-mediated inhibitory phosphorylation of GSK3 limits the regenerative outcome after peripheral nerve injury.
double-knockout embryonic stem cells, as well as GSK-3beta(-/-) mouse embryonic fibroblast cells in which GSK-3alpha was knocked down to demonstrate that both isoforms of GSK-3, GSK-3alpha and GSK-3beta, are required for antiviral immune response.
The two isoforms of GSK-3 are essential integrators of multiple developmental signals that act to maintain normal mammary gland function and suppress tumorigenesis.
GSK3A serine phosphorylation was positively correlated with embryo development
signal pathways converged on inhibitory phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
A mechanism whereby LRP6 (show LRP6 ELISA Kits) stabilizes beta-catenin (show CTNNB1 ELISA Kits) independently of Axin (show AXIN1 ELISA Kits) degradation by directly inhibiting GSK3's phosphorylation of beta-catenin (show CTNNB1 ELISA Kits), is identified.
we demonstrate that PKA, PKC (show FYN ELISA Kits) and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A phosphorylation which subsequently controls cell motility.
lycogen synthase kinase-3 (GSK3) was identified as a substrate of protein kinase c delta (show PKCd ELISA Kits) in breast cancer cells.
GSK3alpha, but not GSK3beta, is necessary in cardiomyocyte survival
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease.
glycogen synthase kinase-3 alpha
, glycogen synthase kinase 3 alpha
, GSK-3 alpha
, serine/threonine-protein kinase GSK3A
, factor A