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anti-Human Huntingtin antibody for Immunohistochemistry

Recommended Huntingtin Antibody (supplied by: Log in to see )

Antigen
Huntingtin (HTT) Antibodies
  • AI256365
  • C430023I11Rik
  • CG9995
  • dHtt
  • dhtt
  • Dmel\\CG9995
  • HD
  • hd
  • Hd
  • Hdh
  • Hsap\\HD
  • htt
  • HTT
  • Htt
  • huntington
  • it15
  • IT15
  • SLC6A4
  • ZHD
Epitope
AA 416-424, pSer421
13
12
12
7
6
5
5
5
5
4
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
124
47
35
7
Host
Rabbit
66
61
2
1
Clonality
Polyclonal
Conjugate
This Huntingtin antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
96
65
41
21
20
18
11
11
11
8
3
3
2
Supplier
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Catalog No. ABIN100604
$ 369.00
Plus shipping costs $45.00 and $21.00 dry ice
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.22053991 ABIN2470221 IHC ELISA WB Rabbit C-Term Log in to see Polyclonal
0.22053991 ABIN2471198 IHC ELISA WB Mouse IgG2a kappa Log in to see 3F1
0.0011363331 ABIN1450584 IHC ELISA Rabbit IgG N-Term Log in to see Polyclonal 3
0.0011363331 ABIN243904 IHC WB Mouse IgG1 N-Term Log in to see
0.0011363331 ABIN1842290 IHC WB Mouse IgG1 AA 1-225 Log in to see 3
0.0011363331 ABIN269391 IHC (fro) IP IHC WB Mouse IgG1 AA 1844-2131 Log in to see HDB4E10
0.0011363331 ABIN153591 IHC (fro) IP IHC WB Mouse IgG1 AA 997-1276 Log in to see HDA3E10
0.0011363331 ABIN1450323 IHC ELISA Rabbit IgG pSer421, N-Term Log in to see Polyclonal
0.0011363331 ABIN790734 IHC WB Mouse IgG N-Term Log in to see H-F5
0.0011363331 ABIN3185117 ELISA IHC Rabbit IgG Ser47 Log in to see Polyclonal
0.0011363331 ABIN3182875 ELISA IHC Rabbit IgG pSer421 Log in to see Polyclonal
0.0011363331 ABIN1607890 FM IHC ELISA WB Rabbit N-Term Log in to see Polyclonal
0.0011363331 ABIN1607891 FM IHC ELISA WB Rabbit C-Term Log in to see Polyclonal
0.0011363331 ABIN2736926 IHC WB Rabbit IgG Log in to see Polyclonal
0.0011363331 ABIN1514987 IHC ELISA WB Rabbit IgG N-Term, pSer13 Log in to see Polyclonal
0.0011363331 ABIN269392 IHC (fro) IP IHC WB Mouse IgG AA 2703-2911 Log in to see HDC8A4
0.0011363331 ABIN1904132 IHC ELISA WB Rabbit Internal Region, pSer1181 Log in to see Polyclonal
0.0011363331 ABIN1904135 IHC ELISA WB Rabbit Internal Region, pSer434 Log in to see Polyclonal
0.0011363331 ABIN1904134 IHC ELISA WB Rabbit Internal Region, pSer421 Log in to see Polyclonal
0.0011363331 ABIN1904133 IHC ELISA WB Rabbit Internal Region, pSer1201 Log in to see Polyclonal

Top referenced anti-Huntingtin antibody for Immunohistochemistry

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Fluorescence Microscopy (FM) 2 Antibodies
Immunochromatography (IC) 8 Antibodies
Immunocytochemistry (ICC) 10 Antibodies
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Immunohistochemistry (Frozen Sections) (IHC (fro)) 20 Antibodies
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General

Antigen Huntingtin (HTT) Antibodies
Epitope AA 416-424, pSer421
(13), (12), (12), (7), (6), (5), (5), (5), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(124), (47), (35), (7)
Host Rabbit
(66), (61), (2), (1)
Clonality
Polyclonal
Conjugate This Huntingtin antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(96), (65), (41), (21), (20), (18), (11), (11), (11), (8), (3), (3), (2)
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Product Details anti-Huntingtin Antibody

Target Details Huntingtin Application Details Handling Images
Characteristics Concentration Definition: by UV absorbance at 280 nm
Sterility Sterile filtered
Immunogen This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding aa 416-424 of Human huntingtin protein.
Isotype IgG

Target Details Huntingtin

Product Details anti-Huntingtin Antibody Application Details Handling Images back to top
Antigen
Alternative Name Huntington (HTT Antibody Abstract)
Background Huntingtin (also known as Huntington's disease protein, Htt and HD protein) is the protein product of a disease gene linked to Huntington's disease, a neuro-degenerative disorder characterized by loss of striatal neurons. This may be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product (see partial protein sequence below). The huntingtin gene locus is large, spanning 180 kb and consisting of 67 exons.  It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. Normal huntingtin protein shows a cytoplasmic localization.  This protein is widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation.
Synonyms: AI256365 antibody, C430023I11Rik antibody, HD antibody, HD protein antibody, HDH antibody, HTT antibody, HUNTINGTON CHOREA antibody, Huntington disease protein antibody, Huntingtin protein antibody, IT15,
Gene ID 3064
UniProt P42858
Pathways PI3K-Akt Signaling

Application Details

Product Details anti-Huntingtin Antibody Target Details Huntingtin Handling Images back to top
Application Notes Anti-Huntingtin pS421 antibody has been tested for use in ELISA, immunohistochemistry and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect bands at approximately 350 kDa and 200 kDa in size corresponding to full-length Huntingtin protein and truncated (hypothetical) Huntingtin protein, respectively, by western blotting in the appropriate cell lysate or extract.   This antibody is specific for the phosphorylated form of Huntingtin protein at the pS421 residue.  The identity of lower molecular bands ~130 kDa is not known.
Restrictions For Research Use only

Handling

Product Details anti-Huntingtin Antibody Target Details Huntingtin Application Details Images back to top
Format Liquid
Concentration 0.6 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C

Images

Product Details anti-Huntingtin Antibody Target Details Huntingtin Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Huntingtin antibody (HTT) (AA 416-424) (ABIN100604) Affinity Purified anti-Huntingtin pS421 antibody was used at a 1:100 dilution to dete...
Western Blotting (WB) image for anti-Huntingtin antibody (HTT) (AA 416-424) (ABIN100604) anti-Huntingtin (HTT) (AA 416-424), (pSer421) antibody (Image 2)
Western Blotting (WB) image for anti-Huntingtin antibody (HTT) (AA 416-424) (ABIN100604) anti-Huntingtin (HTT) (AA 416-424), (pSer421) antibody (Image 3)