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Browse our Huntingtin Proteins (HTT)

Full name:
Huntingtin Proteins (HTT)
On www.antibodies-online.com are 2 Huntingtin (HTT) Proteins from 2 different suppliers available. Additionally we are shipping Huntingtin Antibodies (131) and Huntingtin Kits (16) and many more products for this protein. A total of 151 Huntingtin products are currently listed.
Synonyms:
AI256365, C430023I11Rik, CG9995, dhtt, Dmel\\CG9995, Hd, Hdh, Hsap\\HD, htt, huntington, IT15, SLC6A4, ZHD
list all proteins Gene Name GeneID UniProt
HTT 3064 P42858
HTT 15194 P42859
Rat HTT HTT 29424  

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Huntingtin Proteins (HTT) by Origin

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More Proteins for Huntingtin Interaction Partners

Zebrafish Huntingtin (HTT) interaction partners

  1. These investigations demonstrate a specific 'rate-limiting' role for huntingtin in formation of the telencephalon and the pre-placodal region, and differing levels of requirement for huntingtin function in specific nerve cell types.

  2. the effects of Htt deficiency in early zebrafish development.

  3. In vivo, huntingtin deficient zebrafish had a severe phenotype and reduced expression of LXR (show NR1H3 Proteins) reg'd genes. An LXR (show NR1H3 Proteins) agonist partially rescued the phenotype and expression of LXR (show NR1H3 Proteins) target genes in huntingtin deficient zebrafish during early development.

Fruit Fly (Drosophila melanogaster) Huntingtin (HTT) interaction partners

  1. Htt aggregates cause non-cell-autonomous pathology, including loss of vulnerable neurons that can be prevented by inhibiting endocytosis in these neurons.

  2. Glia regulate steady-state numbers of Htt aggregates expressed in neurons through a clearance mechanism that requires the glial scavenger receptor Draper and downstream phagocytic machinery.

  3. findings support a role for HTT on dynamin 1 (show DNM1 Proteins) function and ER homoeostasis. Proteolysis-induced alteration of this function may be relevant to disease.

  4. Htt modulated histone H3K9 methylation levels at the heterochromatin-euchromatin boundary.

  5. In Drosophila, Huntingtin genetically interacts with autophagy pathway components.

  6. Decreased O-linked GlcNAcylation protects from cytotoxicity mediated by huntingtin exon1 protein fragment

  7. Loss of huntingtin protein results in the disruption of Rab11 vesicle transport.

  8. The specific disruption of Drosophila huntingtin in neuroblast precursors leads to spindle misorientation; Drosophila huntingtin restores spindle misorientation in mammalian cells.

  9. a genomewide RNA interference screen for regulators of mutant Htt aggregation

  10. genes related to nuclear transport, nucleotide processes, and signaling are modifiers of huntingtin aggregation

Human Huntingtin (HTT) interaction partners

  1. Data show that human transgenic mutant huntingtin (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (show ABCB4 Proteins)) which suggests that MDR1 might be a potential therapeutic target for Huntington's disease.

  2. HDAC4 (show HDAC4 Proteins) destabilizes MAP1S (show MAP1S Proteins), suppresses autophagy flux and promotes the accumulation of mHTT aggregates.

  3. Findings indicate that mutant huntingtin (mHTT) aggregates can be transformed into benign species by isomerase FKBP12 (show FKBP1A Proteins).

  4. Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 (show MBNL1 Proteins) and U2AF65 (show U2AF59 Proteins)

  5. The Htt36Q (mutated) showed higher interaction than Htt17Q (native) with SH3GL3. This increased interaction is believed to form aggregates in the cytoplasm that might be a major trigger to cause Huntington's disorder.

  6. RNAi silencing of both HTT alleles in neural stem cells from hESCs disrupted spindle orientation and mislocalized dynein, the p150Glued subunit of dynactin and the large NuMA protein. A 46-glutamine expansion was sufficient for a dominant-negative effect.

  7. USP19_b up-regulates the protein levels of the polyglutamine (polyQ)-containing proteins, ataxin-3 (Atx3 (show ATXN3 Proteins)) and huntingtin (Htt), and thus promotes aggregation of their polyQ-expanded species in cell models

  8. Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes

  9. Alternative HTT splicing eventsin human control and patient post-mortem brains.

  10. As the cholesterol content of the membrane increased, the extent of htt insertion decreased.

Mouse (Murine) Huntingtin (HTT) interaction partners

  1. findings point out age- and cell type-dependent vital functions of Htt and the safety of knocking down neuronal Htt expression in adult brains as a treatment.

  2. selective hypothalamic overexpression of mutant HTT directly leads to a reduction of the TH A13 (show UGT1A10 Proteins) group in the zona incerta with downstream negative effects on BAT (show BAAT Proteins)

  3. Aberrant phosphorylation of AKT (show AKT1 Proteins) and MEK (show MDK Proteins) signalling pathways was identified in cells carrying mutant huntingtin.

  4. Studied the role of the proline-rich region (PRR (show PVRL1 Proteins)) in Huntingtin function using a knock-in allele of the mouse Huntington's disease gene homolog that expressed full-length normal huntingtin lacking PRR (show PVRL1 Proteins).

  5. HdhQ111 mice, with trinucleotide repeat expansion-Htt, exhibit tissue specific metabolite profiles that include striatal lipid accumulation.

  6. Study shows endogenous mouse Huntingtin (HTT) protein is reduced in cilia and accumulates in photoreceptor cell bodies, suggesting that HTT loss function contributes to structural and functional defects of photoreceptor cilia in Huntington's disease mouse

  7. We investigated whether the PPARgamma (show PPARG Proteins) agonist (rosiglitazone) mediates neuroprotection in the mHtt expressing neuroblastoma (show ARHGEF16 Proteins) cell line (N2A).

  8. Data show that G protein-coupled receptor 52 (Gpr52) modulates huntingtin protein (Htt) levels in the striatal cells in vitro and in vivo.

  9. Htt CAG repeat (show CELF3 Proteins) expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation

  10. reduction of SUPT4H (show SUPT4H1 Proteins) in mouse brains is associated with decreased HTT protein aggregation, and in R6/2 mice, also with prolonged lifespan and delay of the motor impairment that normally develops in these animals.

Huntingtin (HTT) Protein Profile

Protein Summary

Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.

Alternative names and synonyms associated with Huntingtin (HTT)

  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4)
  • huntingtin (LOC100216476)
  • huntingtin (htt)
  • huntingtin (Htt)
  • huntingtin (HTT)
  • huntingtin (HDH)
  • AI256365 protein
  • C430023I11Rik protein
  • CG9995 protein
  • dhtt protein
  • Dmel\\CG9995 protein
  • Hd protein
  • Hdh protein
  • Hsap\\HD protein
  • htt protein
  • huntington protein
  • IT15 protein
  • SLC6A4 protein
  • ZHD protein

Protein level used designations for Huntingtin Proteins (HTT)

huntingtin , etID309952.1 , CG9995-PA , CG9995-PB , htt-PA , htt-PB , Huntington's disease protein , huntingtin (Huntington disease) , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 , Huntington disease , huntingtin-like , huntington disease protein , HD protein homolog , Huntington disease gene homolog , huntington disease protein homolog

GENE ID SPECIES
100053721 Equus caballus
100216476 Ovis aries
30214 Danio rerio
43392 Drosophila melanogaster
373520 Strongylocentrotus purpuratus
461084 Pan troglodytes
493287 Xenopus (Silurana) tropicalis
700306 Macaca mulatta
100015315 Monodelphis domestica
100145818 Ciona intestinalis
100219938 Taeniopygia guttata
100329031 Saccoglossus kowalevskii
100403524 Callithrix jacchus
100466808 Ailuropoda melanoleuca
3064 Homo sapiens
15194 Mus musculus
29424 Rattus norvegicus
479074 Canis lupus familiaris
397014 Sus scrofa
615059 Bos taurus
100351801 Oryctolagus cuniculus
422878 Gallus gallus
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