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Browse our anti-MAP3K8 (MAP3K8) Antibodies

Full name:
anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 Antibodies (MAP3K8)
On www.antibodies-online.com are 96 Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Antibodies from 15 different suppliers available. Additionally we are shipping MAP3K8 Proteins (7) and MAP3K8 Kits (5) and many more products for this protein. A total of 120 MAP3K8 products are currently listed.
Synonyms:
c-COT, Cot, Cot/Tpl2, D17TPL2, Est, Estf, MAP3K8, MEKK8, Tpl-2, Tpl2
list all antibodies Gene Name GeneID UniProt
MAP3K8 1326 P41279
MAP3K8 26410 Q07174
MAP3K8 116596 Q63562

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All available anti-MAP3K8 Antibodies

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Top referenced anti-MAP3K8 Antibodies

  1. Human Polyclonal MAP3K8 Primary Antibody for EIA - ABIN358351 : Sánchez-Góngora, Lisbona, de Gregorio, Ballester, Calvo, Pérez-Jurado, Alemany: COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation. in The Journal of biological chemistry 2000 (PubMed)
    Show all 5 references for ABIN358351

  2. Human Polyclonal MAP3K8 Primary Antibody for EIA, IHC (p) - ABIN360360 : Shlomchik, Zharhary, Saunders, Camper, Weigert: A rheumatoid factor transgenic mouse model of autoantibody regulation. in International immunology 1994 (PubMed)
    Show all 5 references for ABIN360360

  3. Human Polyclonal MAP3K8 Primary Antibody for IHC, ELISA - ABIN1532057 : Chan, Chedid, McGovern, Popescu, Miki, Aaronson: Expression cDNA cloning of a serine kinase transforming gene. in Oncogene 1993 (PubMed)

  4. Human Polyclonal MAP3K8 Primary Antibody for WB - ABIN2779366 : Wittwer, Schmitz: NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation. in Biochemical and biophysical research communications 2008 (PubMed)

  5. Chicken Polyclonal MAP3K8 Primary Antibody for WB - ABIN2779365 : Jia, Quinn, Bump, Clark, Clabbers, Hardman, Gagnon, Kamens, Tomlinson, Wishart, Allen: Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinase COT and the complexes with its cellular partner NF-kappa B1 p105. in Archives of biochemistry and biophysics 2005 (PubMed)

More Antibodies against MAP3K8 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) interaction partners

  1. Studies indicate that Tpl2, a MAP3K, participates in a broad range of cancer-related signaling pathways and induces tumorigenesis and progression of many cancers.

  2. the results of the present study demonstrated that the miR (show MLXIP Antibodies)-509-3p RCC (show XRCC1 Antibodies) suppressor was a significant regulator of the MAP3K8 oncogene (show RAB1A Antibodies), suggesting that it may have a potential therapeutic role in the treatment of renal cell carcinoma (show MOK Antibodies)

  3. findings provide a novel perspective on the role of the IL-33 (show IL33 Antibodies)/ST2 (show SULT2A1 Antibodies)/COT signaling pathway in supporting cancer-associated inflammation in the tumor microenvironment

  4. structurally versatile active site significantly impacts the design of potent, low molecular weight COT kinase inhibitors

  5. TPL2 mediates the phosphorylation of a fraction of nucleophosmin (show NPM1 Antibodies) at threonine 199, an event required for its proteasomal degradation and maintenance of steady-state nucleophosmin (show NPM1 Antibodies) levels.

  6. MAP3K8 and miR-17-5p expression were inversely correlated with treatment response

  7. COT interacts with and phosphorylates Pin1 (show PIN1 Antibodies) on Ser16. Consequently, Pin1 (show PIN1 Antibodies) Ser16 phosphorylation by COT increases cyclin D1 (show CCND1 Antibodies) abundance and enhances tumorigenecity of MCF7 cells.

  8. Aberrant expression of A-, B-, and C-RAF (show RAF1 Antibodies), and COT is frequent in PTC (show F9 Antibodies); increased expression of COT is correlated with recurrence of PTC (show F9 Antibodies).

  9. Tpl2 overexpression and downregulation showed significant stimulatory and inhibitory effects on tumorigenic and metastatic potential of ADI PC cells.

  10. Following epithelial injury, intestinal myofibroblasts sense innate or inflammatory signals and activate, via Tpl2, the cyclooxygenase-2 (Cox-2 (show PTGS2 Antibodies))-prostaglandin E2 (PGE2) pathway, which are essential for the epithelial homeostatic response.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) interaction partners

  1. Tpl2 plays a significant role in promoting HCC (show FAM126A Antibodies) development by its pro-inflammatory effect, which suggested that Tpl2 could be a molecular target for HCC (show FAM126A Antibodies) prevention.

  2. Tpl2 null mice displayed low COX-2 (show COX2 Antibodies) mRNA induction in adipose tissue.

  3. The stimulating effect of estradiol on progesterone synthesis relies on the estrogen no-classical protein-coupled receptor 30, and MAP3K8.

  4. these findings establish an essential role for Tpl2 in antiviral host defense mechanisms.

  5. Tpl2 promotes Th1 (show HAND1 Antibodies), but not Th17, differentiation in a T cell transfer model of colitis.

  6. Tpl2 is an essential regulator of reactive oxygen species production during TLR3 (show TLR3 Antibodies)/9 signaling.

  7. Following epithelial injury, intestinal myofibroblasts sense innate or inflammatory signals and activate, via Tpl2, the cyclooxygenase-2 (Cox-2 (show PTGS2 Antibodies))-prostaglandin E2 (PGE2) pathway, which are essential for the epithelial homeostatic response.

  8. Tpl2 regulates various inflammatory pathways by activating the ERK (show EPHB2 Antibodies) mediated MAP kinase (show MAPK1 Antibodies) pathway in innate immune cells such as macrophages and dendritic cells in humans but not in mice.

  9. This study demonstrates a Tpl2-dependent mechanism for macrophage expression of select chemokine (show CCL1 Antibodies) receptors.

  10. Data show that IkappaB kinase (show CHUK Antibodies) (IKK (show CHUK Antibodies)) phosphorylation of the TPL-2 kinase (TPL-2) induces 14-3-3 (show YWHAQ Antibodies) association with TPL-2, stimulating its MEK (show MDK Antibodies) kinase activity, which is essential for TPL-2 activation of ERK-1 (show MAPK3 Antibodies)/2.

MAP3K8 Antigen Profile

Antigen Summary

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

Alternative names and synonyms associated with MAP3K8

  • mitogen-activated protein kinase kinase kinase 8 (MAP3K8) antibody
  • mitogen-activated protein kinase kinase kinase 8 (map3k8) antibody
  • mitogen-activated protein kinase kinase kinase 8 (Map3k8) antibody
  • c-COT antibody
  • Cot antibody
  • Cot/Tpl2 antibody
  • D17TPL2 antibody
  • Est antibody
  • Estf antibody
  • MAP3K8 antibody
  • MEKK8 antibody
  • Tpl-2 antibody
  • Tpl2 antibody

Protein level used designations for MAP3K8

mitogen-activated protein kinase kinase kinase 8 , Ewing sarcoma transformant , cot (cancer Osaka thyroid) oncogene , proto-oncogene c-Cot , proto-oncogene serine/threoine protein kinase , tumor progression locus 2 , COT proto-oncogene serine/threonine-protein kinase , cancer Osaka thyroid oncogene , cancer Osaka thyroid, oncogene , mitogen activated protein kinase kinase kinase 8 , serine/threonine-protein kinase cot , serine/threonine kinase (Tpl-2)

GENE ID SPECIES
450384 Pan troglodytes
100018684 Monodelphis domestica
100063602 Equus caballus
100355566 Oryctolagus cuniculus
100385107 Callithrix jacchus
100480593 Ailuropoda melanoleuca
100541097 Meleagris gallopavo
100562883 Anolis carolinensis
100579516 Nomascus leucogenys
420479 Gallus gallus
1326 Homo sapiens
487085 Canis lupus familiaris
535622 Bos taurus
26410 Mus musculus
116596 Rattus norvegicus
449002 Sus scrofa
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