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Sin1, Rictor, Trc and target of rapamycin (TOR), components of the TOR complex 2 (TORC2), are required for dendritic tiling of class IV da neurons
SIN1 plays an important role in breast cancer.
In colorectal cancer tissues, the Sin1 protein but not mRNA was significantly upregulated while Pdcd4 (show PDCD4 ELISA Kits) protein was downregulated, suggesting that loss of Pdcd4 (show PDCD4 ELISA Kits) might correlate with Sin1 protein level but not mRNA level in colorectal cancer.
SIN1 plays an important role in non-small cell lung cancer; SIN1 is a potential biomarker and a promising target in the treatment of NSCLC
This study provides evidence that Sin1, a known element of the mammalian target of rapamycin (show FRAP1 ELISA Kits) complex 2 (mTORC2 (show CRTC2 ELISA Kits)), is required for Interferon-gamma (show IFNG ELISA Kits)-induced phosphorylation and activation of AKT (show AKT1 ELISA Kits) and that such activation mediates downstream regulation of mTORC1 and its effectors.
Intracellular localization of mTORC2 (show CRTC2 ELISA Kits) component, mSin1, contributes to regulation of Akt (show AKT1 ELISA Kits) phosphorylation.
Akt (show AKT1 ELISA Kits) phosphorylates SIN1 at T86, enhancing mTORC2 (show CRTC2 ELISA Kits) kinase activity, which leads to phosphorylation of Akt (show AKT1 ELISA Kits) S473 by mTORC2 (show CRTC2 ELISA Kits), thereby catalyzing full activation of Akt (show AKT1 ELISA Kits).
MAPKAP1 may represent a novel anti-infection and anti-fibrogenesis genomic locus in chronic schistosomiasis japonica.
mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma.
DNA-PKcs (show PRKDC ELISA Kits)-mTORC2 (show CRTC2 ELISA Kits)(SIN1) association is required for UVB-induced Akt (show AKT1 ELISA Kits) Ser (show SIGLEC1 ELISA Kits)-473 phosphorylation and cell survival.
Estradiol and mTORC2 (show CRTC2 ELISA Kits) cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2 (show TSC2 ELISA Kits)-deficient lymphangioleiomyomatosis cells.
analysis of mTORC2 (show CRTC2 ELISA Kits) components mTOR (show FRAP1 ELISA Kits), Rictor (show RICTOR ELISA Kits) and mSin1 reveals diurnal variation in mouse perivascular adipose tissue
data suggest that DNA-PKcs (show PRKDC ELISA Kits)-SIN1 complexation-mediated Akt (show AKT1 ELISA Kits) activation (Ser (show SIGLEC1 ELISA Kits)-473 phosphorylation) is required for mouse osteoblast differentiation
these findings provide evidence for critical functions for Rictor (show RICTOR ELISA Kits)/Sin1 complexes in type I IFN signaling and the generation of type I IFN antineoplastic responses.
The phosphorylation of SIN1 by Akt (show AKT1 ELISA Kits) was found to regulate mTORC2 (show CRTC2 ELISA Kits) activity in response to growth factors, revealing topological insights into the Akt (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) signaling network.
Sin1 and mTORC2 (show CRTC2 ELISA Kits) are dispensable for the development and activation of T cells but play a role in nTreg-cell differentiation.
mSIN1 protein mediates SGK1 (show SGK1 ELISA Kits) protein interaction with mTORC2 (show CRTC2 ELISA Kits) protein complex and is required for selective activation of the epithelial sodium channel
MAP kinase (show MAPK1 ELISA Kits)-interacting kinase 1 and 2 activity enhances formation of the EIF-4F complex in pachytene spermatocytes but not in round spermatids.
Sin1-mTORC2 (show CRTC2 ELISA Kits) suppresses rag1,2 and il7r (show IL7R ELISA Kits) gene expression through Akt2 (show AKT2 ELISA Kits) in B cells.
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.
, Stress-activated protein kinase [SAPK]-interacting protein
, stress-activated map kinase-interacting protein 1
, mitogen-activated protein kinase associated protein 1
, Target of rapamycin complex 2 subunit MAPKAP1
, target of rapamycin complex 2 subunit MAPKAP1-like
, MEKK2-interacting protein 1
, SAPK-interacting protein 1
, TORC2 subunit MAPKAP1
, mitogen-activated protein kinase 2-associated protein 1
, ras inhibitor MGC2745
, stress-activated map kinase interacting protein 1
, stress-activated protein kinase-interacting 1
, target of rapamycin complex 2 subunit MAPKAP1
, mitogen activated protein kinase associated protein 1
, SAPK interacting protein