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Browse our MAPKAP1 Proteins (MAPKAP1)

Full name:
Mitogen-Activated Protein Kinase Associated Protein 1 Proteins (MAPKAP1)
On www.antibodies-online.com are 4 Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) Proteins from 2 different suppliers available. Additionally we are shipping MAPKAP1 Antibodies (80) and MAPKAP1 Kits (6) and many more products for this protein. A total of 98 MAPKAP1 products are currently listed.
Synonyms:
AI591529, CG10105, D230039K05Rik, Dmel\\CG10105, dSin1, im:7143088, JC310, MAPKAP1, MGC53034, MIP1, si:ch73-242f23.1, Sin1, SIN1b, SIN1g
list all proteins Gene Name GeneID UniProt
MAPKAP1 79109 Q9BPZ7
MAPKAP1 227743 Q8BKH7
Rat MAPKAP1 MAPKAP1 296648 Q6AYF1

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MAPKAP1 Proteins (MAPKAP1) by Origin

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More Proteins for MAPKAP1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) interaction partners

  1. Sin1, Rictor, Trc and target of rapamycin (TOR), components of the TOR complex 2 (TORC2), are required for dendritic tiling of class IV da neurons

Human Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) interaction partners

  1. Akt (show AKT1 Proteins) phosphorylates SIN1 at T86, enhancing mTORC2 (show CRTC2 Proteins) kinase activity, which leads to phosphorylation of Akt (show AKT1 Proteins) S473 by mTORC2 (show CRTC2 Proteins), thereby catalyzing full activation of Akt (show AKT1 Proteins).

  2. MAPKAP1 may represent a novel anti-infection and anti-fibrogenesis genomic locus in chronic schistosomiasis japonica.

  3. mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma.

  4. DNA-PKcs (show PRKDC Proteins)-mTORC2 (show CRTC2 Proteins)(SIN1) association is required for UVB-induced Akt (show AKT1 Proteins) Ser (show SIGLEC1 Proteins)-473 phosphorylation and cell survival.

  5. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient lymphangioleiomyomatosis cells.

  6. results reveal a Sin1-phosphorylation-dependent mTORC2 (show CRTC2 Proteins) regulation, providing a potential molecular mechanism by which mutations in the mTORC1-S6K (show RPS6KB1 Proteins)-Sin1 signalling axis might cause aberrant hyper-activation of the mTORC2 (show CRTC2 Proteins)-Akt (show AKT1 Proteins) pathway

  7. NBS1 (show NBN Proteins) interacts with the mTOR (show FRAP1 Proteins)/Rictor/SIN1 complex through the a.a. 221-402 domain and contributes to the activation of Akt (show AKT1 Proteins) activity.

  8. SIN1 plays an important role in hepatocellular carcinoma invasion and metastasis by facilitating epithelial-mesenchymal transition.

  9. structures show that the C-termini of Avo1 and Sin1 both have the pleckstrin (show PLEK Proteins) homology (PH) domain fold

  10. mSIN1 protein mediates SGK1 (show SGK1 Proteins) protein interaction with mTORC2 (show CRTC2 Proteins) protein complex and is required for selective activation of the epithelial sodium channel

Mouse (Murine) Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1) interaction partners

  1. analysis of mTORC2 components mTOR, Rictor and mSin1 reveals diurnal variation in mouse perivascular adipose tissue

  2. data suggest that DNA-PKcs (show PRKDC Proteins)-SIN1 complexation-mediated Akt (show AKT1 Proteins) activation (Ser (show SIGLEC1 Proteins)-473 phosphorylation) is required for mouse osteoblast differentiation

  3. these findings provide evidence for critical functions for Rictor/Sin1 complexes in type I IFN signaling and the generation of type I IFN antineoplastic responses.

  4. The phosphorylation of SIN1 by Akt (show AKT1 Proteins) was found to regulate mTORC2 (show CRTC2 Proteins) activity in response to growth factors, revealing topological insights into the Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling network.

  5. Sin1 and mTORC2 (show CRTC2 Proteins) are dispensable for the development and activation of T cells but play a role in nTreg-cell differentiation.

  6. mSIN1 protein mediates SGK1 (show SGK1 Proteins) protein interaction with mTORC2 (show CRTC2 Proteins) protein complex and is required for selective activation of the epithelial sodium channel

  7. MAP kinase (show MAPK1 Proteins)-interacting kinase 1 and 2 activity enhances formation of the EIF-4F complex in pachytene spermatocytes but not in round spermatids.

  8. Sin1-mTORC2 (show CRTC2 Proteins) suppresses rag1,2 and il7r (show IL7R Proteins) gene expression through Akt2 (show AKT2 Proteins) in B cells.

  9. Results reveal that the SIN1-rictor-mTOR (show FRAP1 Proteins) function in Akt (show AKT1 Proteins)-Ser473 phosphorylation is required for TORC2 (show CRTC2 Proteins) function in cell survival but is dispensable for TORC1 (show CRTC1 Proteins) function.

  10. Sin1 together with Rictor are key components of mTORC2 (show CRTC2 Proteins) and play an essential role in Akt (show AKT1 Proteins) phosphorylation and signaling

MAPKAP1 Protein Profile

Protein Summary

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.

Alternative names and synonyms associated with MAPKAP1

  • SAPK-interacting protein 1 (Sin1)
  • mitogen-activated protein kinase associated protein 1 (MAPKAP1)
  • mitogen-activated protein kinase associated protein 1 (mapkap1)
  • mitogen-activated protein kinase associated protein 1 (Mapkap1)
  • AI591529 protein
  • CG10105 protein
  • D230039K05Rik protein
  • Dmel\\CG10105 protein
  • dSin1 protein
  • im:7143088 protein
  • JC310 protein
  • MAPKAP1 protein
  • MGC53034 protein
  • MIP1 protein
  • si:ch73-242f23.1 protein
  • Sin1 protein
  • SIN1b protein
  • SIN1g protein

Protein level used designations for MAPKAP1

CG10105-PA , Sin1-PA , Stress-activated protein kinase [SAPK]-interacting protein , stress-activated map kinase-interacting protein 1 , mitogen-activated protein kinase associated protein 1 , Target of rapamycin complex 2 subunit MAPKAP1 , target of rapamycin complex 2 subunit MAPKAP1-like , MEKK2-interacting protein 1 , SAPK-interacting protein 1 , TORC2 subunit MAPKAP1 , mSIN1 , mitogen-activated protein kinase 2-associated protein 1 , ras inhibitor MGC2745 , stress-activated map kinase interacting protein 1 , stress-activated protein kinase-interacting 1 , target of rapamycin complex 2 subunit MAPKAP1 , mitogen activated protein kinase associated protein 1 , SAPK interacting protein

GENE ID SPECIES
36604 Drosophila melanogaster
464736 Pan troglodytes
480724 Canis lupus familiaris
492604 Danio rerio
100101680 Xenopus (Silurana) tropicalis
100390680 Callithrix jacchus
100481486 Ailuropoda melanoleuca
100601949 Nomascus leucogenys
79109 Homo sapiens
227743 Mus musculus
296648 Rattus norvegicus
533861 Bos taurus
395627 Gallus gallus
380158 Xenopus laevis
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