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Sin1, Rictor, Trc and target of rapamycin (TOR), components of the TOR complex 2 (TORC2), are required for dendritic tiling of class IV da neurons
SIN1 plays an important role in non-small cell lung cancer; SIN1 is a potential biomarker and a promising target in the treatment of NSCLC
This study provides evidence that Sin1, a known element of the mammalian target of rapamycin (show FRAP1 Proteins) complex 2 (mTORC2 (show CRTC2 Proteins)), is required for Interferon-gamma (show IFNG Proteins)-induced phosphorylation and activation of AKT (show AKT1 Proteins) and that such activation mediates downstream regulation of mTORC1 and its effectors.
Intracellular localization of mTORC2 (show CRTC2 Proteins) component, mSin1, contributes to regulation of Akt (show AKT1 Proteins) phosphorylation.
Akt (show AKT1 Proteins) phosphorylates SIN1 at T86, enhancing mTORC2 (show CRTC2 Proteins) kinase activity, which leads to phosphorylation of Akt (show AKT1 Proteins) S473 by mTORC2 (show CRTC2 Proteins), thereby catalyzing full activation of Akt (show AKT1 Proteins).
MAPKAP1 may represent a novel anti-infection and anti-fibrogenesis genomic locus in chronic schistosomiasis japonica.
mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma.
DNA-PKcs (show PRKDC Proteins)-mTORC2 (show CRTC2 Proteins)(SIN1) association is required for UVB-induced Akt (show AKT1 Proteins) Ser (show SIGLEC1 Proteins)-473 phosphorylation and cell survival.
Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient lymphangioleiomyomatosis cells.
results reveal a Sin1-phosphorylation-dependent mTORC2 (show CRTC2 Proteins) regulation, providing a potential molecular mechanism by which mutations in the mTORC1-S6K (show RPS6KB1 Proteins)-Sin1 signalling axis might cause aberrant hyper-activation of the mTORC2 (show CRTC2 Proteins)-Akt (show AKT1 Proteins) pathway
NBS1 (show NBN Proteins) interacts with the mTOR (show FRAP1 Proteins)/Rictor/SIN1 complex through the a.a. 221-402 domain and contributes to the activation of Akt (show AKT1 Proteins) activity.
analysis of mTORC2 components mTOR, Rictor and mSin1 reveals diurnal variation in mouse perivascular adipose tissue
data suggest that DNA-PKcs (show PRKDC Proteins)-SIN1 complexation-mediated Akt (show AKT1 Proteins) activation (Ser (show SIGLEC1 Proteins)-473 phosphorylation) is required for mouse osteoblast differentiation
these findings provide evidence for critical functions for Rictor/Sin1 complexes in type I IFN signaling and the generation of type I IFN antineoplastic responses.
The phosphorylation of SIN1 by Akt (show AKT1 Proteins) was found to regulate mTORC2 (show CRTC2 Proteins) activity in response to growth factors, revealing topological insights into the Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling network.
Sin1 and mTORC2 (show CRTC2 Proteins) are dispensable for the development and activation of T cells but play a role in nTreg-cell differentiation.
mSIN1 protein mediates SGK1 (show SGK1 Proteins) protein interaction with mTORC2 (show CRTC2 Proteins) protein complex and is required for selective activation of the epithelial sodium channel
MAP kinase (show MAPK1 Proteins)-interacting kinase 1 and 2 activity enhances formation of the EIF-4F complex in pachytene spermatocytes but not in round spermatids.
Sin1-mTORC2 (show CRTC2 Proteins) suppresses rag1,2 and il7r (show IL7R Proteins) gene expression through Akt2 (show AKT2 Proteins) in B cells.
Results reveal that the SIN1-rictor-mTOR (show FRAP1 Proteins) function in Akt (show AKT1 Proteins)-Ser473 phosphorylation is required for TORC2 (show CRTC2 Proteins) function in cell survival but is dispensable for TORC1 (show CRTC1 Proteins) function.
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.
, Stress-activated protein kinase [SAPK]-interacting protein
, stress-activated map kinase-interacting protein 1
, mitogen-activated protein kinase associated protein 1
, Target of rapamycin complex 2 subunit MAPKAP1
, target of rapamycin complex 2 subunit MAPKAP1-like
, MEKK2-interacting protein 1
, SAPK-interacting protein 1
, TORC2 subunit MAPKAP1
, mitogen-activated protein kinase 2-associated protein 1
, ras inhibitor MGC2745
, stress-activated map kinase interacting protein 1
, stress-activated protein kinase-interacting 1
, target of rapamycin complex 2 subunit MAPKAP1
, mitogen activated protein kinase associated protein 1
, SAPK interacting protein