Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Decreased and increased copy numbers of NCF1 predispose to and protect against SLE.
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (show HCK Proteins)-dependent activation of PKCdelta (show PKCd Proteins), which stimulates PKCgamma (show PRKCG Proteins), resulting in translocation of phosphorylated p47(phox).
There was an increased frequency of the NCF1-339 T allele in patients with systemic lupus erythematosus. The NCF1-339 T allele reduced extracellular ROS (show ROS1 Proteins) production in neutrophils and led to an increase expression of type 1 interferon (show IFNA Proteins)-regulated genes.
Skeletal muscle protein expression of the NADPH oxidase (show NOX1 Proteins) subunits p22(phox (show CYBA Proteins)), p47(phox), and p67(phox (show NCF2 Proteins)) was increased in obese relative to lean subjects, where p22(phox (show CYBA Proteins)) and p67(phox (show NCF2 Proteins)) expression was attenuated by exercise training in obese subjects.
A novel role for Spns2 (show SPNS2 Proteins) and S1P1 (show S1PR1 Proteins)&2 in the activation of p47(phox) and production of reactive oxygen species involved in hyperoxia-mediated lung injury.
Study provides evidence for a novel PKC-zeta (show PRKCZ Proteins) to p47phox interaction that is required for cell transformation from blebbishields and ROS (show ROS1 Proteins) production in cancer cells.
Overexpression of p47phox is associated with increased migration/metastasis rate in melanoma.
A rare mutation in NCF1 encoding p47phox of the leukocyte NADPH oxidase (show NOX1 Proteins) causes lack of superoxide generation, leads to chronic granulomatous disease and was recently (1200-2300 years ago) introduced into the Kavkazi Jewish population
Data show that diphenylene iodonium (DPI) and apocynin can reduce hyperoxia-induced reactive oxygen species (ROS) production by decreasing the translocation and level of NADPH Oxidase p47phox.
increased levels of gp91phox (show CYBB Proteins), p47phox and p22phox (show CYBA Proteins) likely account for the interferon-gamma (show IFNG Proteins) mediated enhancement of dimethyl sulfoxide-induced Nox2 (show CYBB Proteins) activity.
we used the Ang II (show AGT Proteins) infused hph-1 (show EGLN2 Proteins) mice to examine the roles of NOX isoforms in the development of AAA (show AAAS Proteins). We generated double mutants of hph-1 (show EGLN2 Proteins)-NOX1 (show NOX1 Proteins), hph-1 (show EGLN2 Proteins)-NOX2 (show CYBB Proteins), hph-1 (show EGLN2 Proteins)-p47phox, and hph-1 (show EGLN2 Proteins)-NOX4 (show NOX4 Proteins)
Mice bearing point mutation in the Ncf1-gene develop fewer osteoclasts after ovariectomy (ovx) than wild-type mice. However, irrespective of genotype, bone mineral density decreases after ovx, indicating that a compensatory mechanism retains bone degradation after ovx.
The authors demonstrated a significant role of the host NADPH oxidase (show NOX1 Proteins) in promoting chronic inflammatory pathology in the oviduct following chlamydial infection.
data partly explains the discrepancy of the phenotypes reported earlier utilizing the Ncf1m1J mice or Ncf1 knockout mice.
Data (including data from studies in transgenic mice) suggest that ability to generate Ncf1-derived superoxide, specifically in CD4 (show CD4 Proteins)-positive T-lymphocytes, is key for development of autoimmune responses in type 1 diabetes.
The Park7 (show PARK7 Proteins) binds to p47(phox), a subunit of the NADPH oxidase (show NOX1 Proteins), to promote NADPH oxidase (show NOX1 Proteins)-dependent production of ROS (show ROS1 Proteins).
p47(phox)-dependent NADPH oxidases are a major glomerular source of reactive oxygen species, contributing to kidney injury
p47phox mRNA expression was increased in diet-induced obese (DIO) mice. p47phox suppresses collateral vessel growth after femoral artery ligation in DIO mice.
These findings suggest that a p47(phox)-dependent NAD(P)H (show NQO1 Proteins) oxidase mediates the increase in diaphragm oxidants and contractile dysfunction in chronic heart failure.
The present study provides evidence that augmented EGFRtk impairs vascular function by NADPH oxidase (show NOX1 Proteins)-dependent mechanism. Therefore, EGFRtk and oxidative stress should be potential targets to treat vascular dysfunction in TD2.
Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress.
two novel splice variants designed as NCF1-TV1 (retained intron 6) and NCF1-TV2 (retained part of intron 8)encoding two putative truncated proteins (239AA and 283AA). Two splice variants were up-regulated in the mastitis-infected cows' mammary tissues, blood and neutrophils compared with these of healthy cows.
A p47(phox) and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C.
Angiotensin II inhibits the Na+/K+ pump via PKC-dependent activation of NADPH oxidase (show NOX1 Proteins) subunits.
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.
47 kDa autosomal chronic granulomatous disease protein
, 47 kDa neutrophil oxidase factor
, NADPH oxidase organizer 2
, SH3 and PX domain-containing protein 1A
, neutrophil NADPH oxidase factor 1
, neutrophil cytosol factor 1
, neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)
, nox organizer 2
, nox-organizing protein 2
, NADPH oxidase subunit (47 kD)
, NADPH oxidase subunit (47kDa)
, phagocyte oxidase 47 kDa
, neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1)
, NADPH oxidase p47-phox
, predicted neutrophil cytosolic factor 1