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Browse our NCF1 Proteins (NCF1)

Full name:
Neutrophil Cytosol Factor 1 Proteins (NCF1)
On are 14 Neutrophil Cytosol Factor 1 (NCF1) Proteins from 8 different suppliers available. Additionally we are shipping NCF1 Antibodies (219) and NCF1 Kits (16) and many more products for this protein. A total of 269 NCF1 products are currently listed.
Ncf-1, NCF1A, NOXO2, p47, p47phox, SH3PXD1A
list all proteins Gene Name GeneID UniProt
NCF1 653361 P14598
NCF1 17969 Q09014
Rat NCF1 NCF1 114553  

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NCF1 Proteins (NCF1) by Origin

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Top referenced NCF1 Proteins

  1. Human NCF1 Protein expressed in Escherichia coli (E. coli) - ABIN667805 : Doerries, Grote, Hilfiker-Kleiner, Luchtefeld, Schaefer, Holland, Sorrentino, Manes, Schieffer, Drexler, Landmesser: Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction. in Circulation research 2007 (PubMed)
    Show all 2 references for ABIN667805

More Proteins for NCF1 Interaction Partners

Human Neutrophil Cytosol Factor 1 (NCF1) interaction partners

  1. Study provides evidence for a novel PKC-zeta (show PRKCZ Proteins) to p47phox interaction that is required for cell transformation from blebbishields and ROS (show ROS1 Proteins) production in cancer cells.

  2. Overexpression of p47phox is associated with increased migration/metastasis rate in melanoma.

  3. A rare mutation in NCF1 encoding p47phox of the leukocyte NADPH oxidase (show NOX1 Proteins) causes lack of superoxide generation, leads to chronic granulomatous disease and was recently (1200-2300 years ago) introduced into the Kavkazi Jewish population

  4. Data show that diphenylene iodonium (DPI) and apocynin can reduce hyperoxia-induced reactive oxygen species (ROS) production by decreasing the translocation and level of NADPH Oxidase p47phox.

  5. increased levels of gp91phox (show CYBB Proteins), p47phox and p22phox (show CYBA Proteins) likely account for the interferon-gamma (show IFNG Proteins) mediated enhancement of dimethyl sulfoxide-induced Nox2 (show CYBB Proteins) activity.

  6. Results identifies p47phox-dependent NADPH oxidase (show NOX1 Proteins) activity as a critical component of Angpt-1 (show ANGPT1 Proteins)-mediated endothelial barrier defense against classic inflammatory permeability factors.

  7. DCLRE1C (show DCLRE1C Proteins) and NCF1 mutations have been found by whole-genome sequencing to cause primary immunodeficiency in unrelated patients.

  8. TLR8 (show TLR8 Proteins), but not TLR7 (show TLR7 Proteins), is involved in priming of human neutrophil reactive oxygen species production by inducing the phosphorylation of p47phox and p38 MAPK (show MAPK14 Proteins).

  9. Reduced carotid but not coronary artery atherosclerosis in patients with chronic granulomatous disease despite the high prevalence of traditional risk factors raises questions about the role of NADPH oxidase (show NOX1 Proteins) in the pathogenesis of atherosclerosis.

  10. Four novel mutations in the NCF1, NCF2 (show NCF2 Proteins), and CYBB (show CYBB Proteins) genees have been identified in chronic granulomatous disease patients in Morocco.

Mouse (Murine) Neutrophil Cytosol Factor 1 (NCF1) interaction partners

  1. The authors demonstrated a significant role of the host NADPH oxidase (show NOX1 Proteins) in promoting chronic inflammatory pathology in the oviduct following chlamydial infection.

  2. data partly explains the discrepancy of the phenotypes reported earlier utilizing the Ncf1m1J mice or Ncf1 knockout mice.

  3. Data (including data from studies in transgenic mice) suggest that ability to generate Ncf1-derived superoxide, specifically in CD4 (show CD4 Proteins)-positive T-lymphocytes, is key for development of autoimmune responses in type 1 diabetes.

  4. The Park7 (show PARK7 Proteins) binds to p47(phox), a subunit of the NADPH oxidase (show NOX1 Proteins), to promote NADPH oxidase (show NOX1 Proteins)-dependent production of ROS (show ROS1 Proteins).

  5. p47(phox)-dependent NADPH (show FDXR Proteins) oxidases are a major glomerular source of reactive oxygen species, contributing to kidney injury

  6. p47phox mRNA expression was increased in diet-induced obese (DIO) mice. p47phox suppresses collateral vessel growth after femoral artery ligation in DIO mice.

  7. These findings suggest that a p47(phox)-dependent NAD(P)H (show NQO1 Proteins) oxidase mediates the increase in diaphragm oxidants and contractile dysfunction in chronic heart failure.

  8. The present study provides evidence that augmented EGFRtk impairs vascular function by NADPH oxidase (show NOX1 Proteins)-dependent mechanism. Therefore, EGFRtk and oxidative stress should be potential targets to treat vascular dysfunction in TD2.

  9. NOX2 (show CYBB Proteins)/ROS (show ROS1 Proteins) activity in macrophages signals the development of antigen-specific CD8 (show CD8A Proteins)(+)T cell response.

  10. p47phox plays a critical role in the regulation of adventitial fibroblast proliferation and migration and may be a new therapeutic target for neointimal hyperplasia

Cow (Bovine) Neutrophil Cytosol Factor 1 (NCF1) interaction partners

  1. Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress.

  2. two novel splice variants designed as NCF1-TV1 (retained intron 6) and NCF1-TV2 (retained part of intron 8)encoding two putative truncated proteins (239AA and 283AA). Two splice variants were up-regulated in the mastitis-infected cows' mammary tissues, blood and neutrophils compared with these of healthy cows.

  3. A p47(phox) and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C.

Rabbit Neutrophil Cytosol Factor 1 (NCF1) interaction partners

  1. Angiotensin II inhibits the Na+/K+ pump via PKC-dependent activation of NADPH oxidase (show NOX1 Proteins) subunits.

NCF1 Protein Profile

Protein Summary

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.

Alternative names and synonyms associated with NCF1

  • neutrophil cytosolic factor 1 (NCF1)
  • neutrophil cytosolic factor 1 (Ncf1)
  • Ncf-1 protein
  • NCF1A protein
  • NOXO2 protein
  • p47 protein
  • p47phox protein
  • SH3PXD1A protein

Protein level used designations for NCF1

47 kDa autosomal chronic granulomatous disease protein , 47 kDa neutrophil oxidase factor , NADPH oxidase organizer 2 , NCF-1 , NCF-47K , SH3 and PX domain-containing protein 1A , neutrophil NADPH oxidase factor 1 , neutrophil cytosol factor 1 , neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) , nox organizer 2 , nox-organizing protein 2 , p47-phox , NADPH oxidase subunit (47 kD) , NADPH oxidase subunit (47kDa) , phagocyte oxidase 47 kDa , neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1) , NADPH oxidase p47-phox , predicted neutrophil cytosolic factor 1

653361 Homo sapiens
17969 Mus musculus
114553 Rattus norvegicus
281345 Bos taurus
100008803 Oryctolagus cuniculus
100134857 Sus scrofa
607700 Canis lupus familiaris
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