Browse our anti-PDK1 (PDK1) Antibodies

Full name:
anti-Pyruvate Dehydrogenase Kinase, Isozyme 1 Antibodies (PDK1)
On www.antibodies-online.com are 16 Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) Antibodies from 5 different suppliers available. Additionally we are shipping PDK1 Proteins (8) and PDK1 Kits (7) and many more products for this protein. A total of 32 PDK1 products are currently listed.
Synonyms:
B830012B01, D530020C15Rik, si:zfos-979f1.3
list all antibodies Gene Name GeneID UniProt
PDK1 228026 Q8BFP9
PDK1 5163 Q15118
PDK1 116551  

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Mouse (Murine) Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) interaction partners

  1. PDK1 (show PDPK1 Antibodies) has broad effects in hematopoiesis and is a critical factor for engraftment of both hematopoietic stem cells and multipotent progenitors upon transplantation to recipient mice.

  2. our results offer significant insight into how PIK3CA (show PIK3CA Antibodies) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 (show PDPK1 Antibodies) and TGFb (show TGFB1 Antibodies) signaling in advanced HNSCC patients with PIK3CA (show PIK3CA Antibodies) amplification

  3. PTEN (show PTEN Antibodies) is required for stabilization of planar cell packing in the neural plate and for the formation of stable apical-basal microtubule arrays, while PDPK1 (show PDPK1 Antibodies) is required for stabilization of apical junctions during epithelial morphogenesis.

  4. results thus reveal an essential role for the PDK1 (show PDPK1 Antibodies)-Akt (show AKT1 Antibodies) pathway in the regulation of a key step of neuronal migration.

  5. PDK1 (show PDPK1 Antibodies) plays a pivotal role in regulating cardiac function and tumor metastasis by interfering with microenvironment.

  6. Our data suggest that two arms of the glucose metabolism synergistically regulate the differential activation of macrophages. Our findings also highlight the central role of PDK1 (show PDPK1 Antibodies) in this event via controlling glycolysis and glucose oxidation.

  7. PDHK1 is expressed in Th17 cells, but not Th1 (show HAND1 Antibodies) cells, and at low levels in Tregs, and inhibition or knockdown of PDHK1 selectively suppressed Th17 cells and increased Tregs.

  8. The tyrosine phosphorylation enhances PDHK1 kinase activity by promoting ATP and PDC (show PDC Antibodies) binding.

  9. Pdk1 (show PDPK1 Antibodies) enzyme is critical in conserving mitochondrial function by diverting metabolic intermediates to glycolysis

Human Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) interaction partners

  1. Ribociclib, in combination with GSK2334470 or the PI3Kalpha (show PIK3CA Antibodies) inhibitor alpelisib, decreased xenograft tumor growth more potently than each drug alone. Taken together, our results highlight a role for the PI3K (show PIK3CA Antibodies)-PDK1 signaling pathway in mediating acquired resistance to CDK4/6 (show CDK4 Antibodies) inhibitors.

  2. dicumarol potently inhibited the kinase activity of PDK1, shifted the glucose metabolism from aerobic glycolysis to oxidative phosphorylation, generated a higher level of reactive oxygen species (ROS (show ROS1 Antibodies)), attenuated the mitochondrial membrane potential (MMP), induced apoptosis, and reduced cell viability in vitro.

  3. our results offer significant insight into how PIK3CA (show PIK3CA Antibodies) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K (show PIK3CA Antibodies)/PDK1 and TGFb (show TGFB1 Antibodies) signaling in advanced HNSCC patients with PIK3CA (show PIK3CA Antibodies) amplification

  4. miR (show MLXIP Antibodies)-379 could function as a tumour-suppressing miRNA via targeting PDK1 in osteosarcoma.

  5. These results also suggest that inhibition of HIF-1a (show HIF1A Antibodies) with 2-MeOE2 sensitizes radioresistant melanoma cells 435R to X-ray irradiation through targeting the glycolysis that is regulated by PDK1

  6. PDK1 is frequently upregulated in primary nasopharyngeal carcinoma and may serve as a prognostic marker.

  7. A new function for PDK1 in metabolic reprogramming, which could be used to indicate the prognosis of Non small cell lung cancer and provide targeted therapeutic strategy for clinical treatment.

  8. Our results demonstrated that down-regulation of SDHB (show SDHB Antibodies) and up-regulation of PDK1 may be novel biomarkers for predicting advanced tumor progression and unfavorable prognosis in recurrent nasopharyngeal carcinoma patients

  9. n the conditon of miR (show MLXIP Antibodies)- 128b over-expression, we also observed spontaneous inactivation of the Akt (show AKT1 Antibodies)/NF-kappaB (show NFKB1 Antibodies) signalling, implying PDK1 was a potential regulator of this pathway. In conclusion, our study shed some novel light on miR (show MLXIP Antibodies)-128b-PDK1/Akt (show AKT1 Antibodies)/NF-kappaB (show NFKB1 Antibodies) axis onGastric cancer (GC) progression

  10. Dichloroacetate, an Iihibitor of PDK1, can reverse the mitochondrial suppression of renal cell carcinoma (show MOK Antibodies) and decrease HIF transcriptional activity, decreasing tumor growth and angiogenesis.

Pig (Porcine) Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) interaction partners

  1. Dephosphorylation of PDK1 may be a molecular switch for enhancement of protein tyrosine phosphorylation and flagellar hyperactivation in boar spermatozoa.

PDK1 Antigen Profile

Antigen Summary

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.

Alternative names and synonyms associated with PDK1

  • pyruvate dehydrogenase kinase, isozyme 1 (PDK1) antibody
  • pyruvate dehydrogenase kinase, isoenzyme 1 (Pdk1) antibody
  • pyruvate dehydrogenase kinase, isozyme 1 (Pdk1) antibody
  • pyruvate dehydrogenase kinase, isozyme 1 (pdk1) antibody
  • B830012B01 antibody
  • D530020C15Rik antibody
  • si:zfos-979f1.3 antibody

Protein level used designations for PDK1

pyruvate dehydrogenase kinase, isoenzyme 1 , pyruvate dehydrogenase kinase, isozyme 1 , pyruvate dehydrogenase [lipoamide] kinase isozyme 1, mitochondrial-like , PDH kinase 1 , [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial , mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1 , PDK p48 , pyruvate dehydrogenase kinase 1

GENE ID SPECIES
100218846 Taeniopygia guttata
100402844 Callithrix jacchus
100601990 Nomascus leucogenys
228026 Mus musculus
5163 Homo sapiens
116551 Rattus norvegicus
555840 Danio rerio
425972 Gallus gallus
100286871 Sus scrofa
528655 Bos taurus
476828 Canis lupus familiaris
432080 Xenopus laevis
100064091 Equus caballus
100351323 Oryctolagus cuniculus
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