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Browse our anti-PDK2 (PDK2) Antibodies

Full name:
anti-Pyruvate Dehydrogenase Kinase, Isozyme 2 Antibodies (PDK2)
On www.antibodies-online.com are 141 Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) Antibodies from 19 different suppliers available. Additionally we are shipping PDK2 Proteins (6) and PDK2 Kits (2) and many more products for this protein. A total of 157 PDK2 products are currently listed.
Synonyms:
3j828, MGC52849, MGC132353, PDHK2, Pdk, PDK2, PDKII, zgc:56209

Most Popular Reactivities for anti-PDK2 (PDK2) Antibodies

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anti-Mouse (Murine) PDK2 Antibodies:

anti-Human PDK2 Antibodies:

anti-Rat (Rattus) PDK2 Antibodies:

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Top referenced anti-PDK2 Antibodies

  1. Human Polyclonal PDK2 Primary Antibody for IHC (p), WB - ABIN391037 : McClenaghan, Scullion, Mion, Hewage, Malthouse, Flatt, Newsholme, Brennan: Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells. in Clinical science (London, England : 1979) 2009 (PubMed)
    Show all 9 references for ABIN391037

  2. Human Polyclonal PDK2 Primary Antibody for FACS, IHC (p) - ABIN954072 : Li, Kato, Chuang: Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate. in The Journal of biological chemistry 2009 (PubMed)
    Show all 4 references for ABIN954072

  3. Human Polyclonal PDK2 Primary Antibody for EIA, IHC (p) - ABIN359096 : Richards, Sardella, Schulte: Regulation of pyruvate dehydrogenase in the common killifish, Fundulus heteroclitus, during hypoxia exposure. in American journal of physiology. Regulatory, integrative and comparative physiology 2008 (PubMed)
    Show all 3 references for ABIN359096

  4. Human Polyclonal PDK2 Primary Antibody for FACS, IHC (p) - ABIN653784 : Sun, Chang, Fu, Liu, Califano: Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1? stabilization. in PLoS ONE 2011 (PubMed)
    Show all 2 references for ABIN653784

  5. Cow (Bovine) Polyclonal PDK2 Primary Antibody for IHC, WB - ABIN2777433 : Hiromasa, Yan, Roche: Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r. in Biochemistry 2008 (PubMed)

  6. Human Polyclonal PDK2 Primary Antibody for ELISA, WB - ABIN1535242 : Greenman, Stephens, Smith, Dalgliesh, Hunter, Bignell, Davies, Teague, Butler, Stevens, Edkins, OMeara, Vastrik, Schmidt, Avis, Barthorpe, Bhamra, Buck, Choudhury, Clements, Cole, Dicks, Forbes, Gray et al.: Patterns of somatic mutation in human cancer genomes. ... in Nature 2007 (PubMed)

More Antibodies against PDK2 Interaction Partners

Mouse (Murine) Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) interaction partners

  1. PDK2/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy.

  2. Double-knockout mice with global deletion of PDK2 and PDK4 (show PDK4 Antibodies), which results in constitutively activated pyruvate dehydrogenase (show PDP Antibodies), preferentially oxidize glucose in muscle.

  3. The final compound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits all four PDK isoforms with IC50 = 0.8 muM for PDK2.

  4. The Pdk4 (show PDK4 Antibodies) gene knockdown led to better glucose tolerance than the Pdk2 gene knockdown.

  5. loss of both Pdk2 and Pdk4 (show PDK4 Antibodies) attenuated HSC (show FUT1 Antibodies) quiescence, glycolysis, and transplantation capacity.

  6. Results established that wild-type p53 (show TP53 Antibodies) prevents manifestation of the Warburg effect by controlling Pdk2. These findings elucidate a new mechanism by which p53 (show TP53 Antibodies) suppresses tumorigenesis acting at the level of cancer cell metabolism.

  7. PDK2 activity is essential, even at rest, in regulation of carbohydrate oxidation and production of reducing equivalents for the electron transport chain.

  8. mitochondrial ND2 (show MT-ND2 Antibodies) mutation contributes to HIF1alpha (show HIF1A Antibodies) accumulation via increased ROS (show ROS1 Antibodies) production, up-regulation of PDK2, attenuating PDH (show PDP Antibodies) activity, thereby increasing pyruvate, resulting in HIF1alpha (show HIF1A Antibodies) stabilization

Human Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) interaction partners

  1. High glycolysis and PDK2 overexpression are closely linked to cisplatin resistance in head and neck cancer cells, which can be reversed by PDK2 nhibition.

  2. both PDK 1 (show PDK1 Antibodies) and 2 isoforms are overexpressed in cutaneous melanoma compared to nevi, this expression being associated with the expression of the mTOR (show FRAP1 Antibodies) pathway effectors and independent of the BRAF (show BRAF Antibodies) mutational status

  3. The findings of the present study reveal a novel survival pathway that functionally couples the unique glycolytic phenotype in cancer cells to hypoxia resistance via a PDK2-dependent mechanism that switches Bnip3 (show BNIP3 Antibodies) from cell death to survival.

  4. The final compound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits all four PDK isoforms with IC50 = 0.8 muM for PDK2.

  5. Germline mutations in PKD2 (show PKD2 Antibodies) gene is associated with autosomal-dominant polycystic kidney disease.

  6. we for the first time demonstrated that a low-nutrient condition drives cancer cells to utilize glycolysis to produce ATP, and this increases the Warburg effect through a novel mechanism involving ROS (show ROS1 Antibodies)/AMPK (show PRKAA1 Antibodies)-dependent activation of PDK.

  7. Mitochondrial activation by inhibition of PDKII suppresses HIF1a (show HIF1A Antibodies) signaling and angiogenesis in cancer.

  8. Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species.

  9. Results established that wild-type p53 (show TP53 Antibodies) prevents manifestation of the Warburg effect by controlling Pdk2. These findings elucidate a new mechanism by which p53 (show TP53 Antibodies) suppresses tumorigenesis acting at the level of cancer cell metabolism.

  10. PKD2 (show PKD2 Antibodies) mutations are associated with autosomal dominant polycystic kidney disease.

PDK2 Antigen Profile

Antigen Summary

This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with PDK2

  • pyruvate dehydrogenase kinase, isozyme 4 (pdk4) antibody
  • pyruvate dehydrogenase kinase, isoenzyme 2 (pdk2) antibody
  • pyruvate dehydrogenase kinase, isozyme 2 (PDK2) antibody
  • pyruvate dehydrogenase kinase, isoenzyme 2 (Pdk2) antibody
  • pyruvate dehydrogenase kinase, isozyme 2 (Pdk2) antibody
  • 3j828 antibody
  • MGC52849 antibody
  • MGC132353 antibody
  • PDHK2 antibody
  • Pdk antibody
  • PDK2 antibody
  • PDKII antibody
  • zgc:56209 antibody

Protein level used designations for PDK2

pyruvate dehydrogenase kinase 2 , pyruvate dehydrogenase kinase, isoenzyme 2 , [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial , pyruvate dehydrogenase kinase, isozyme 2 , PDH kinase 2 , pyruvate dehydrogenase 2 , pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial , PDK P45 , pyruvate dehydrogenase kinase 2 subunit p45 (PDK2)

GENE ID SPECIES
379789 Xenopus laevis
393971 Danio rerio
468402 Pan troglodytes
18604 Mus musculus
5164 Homo sapiens
81530 Rattus norvegicus
524075 Bos taurus
100516037 Sus scrofa
491075 Canis lupus familiaris
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