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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||3 Antibodies|
|Flow Cytometry (FACS)||17 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||3 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||60 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||24 Antibodies|
|RNA Interference (RNAi)||1 Antibodies|
|Western Blotting (WB)||106 Antibodies|
|Antigen||Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) Antibodies|
|Conjugate||This PDK2 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-PDK2 AntibodyTarget Details PDK2 Application Details Handling References for anti-PDK2 Antibody (ABIN954072) Images
|Specificity||This antibody recognizes Human PDK2.|
|Purification||Protein A column, followed by protein affinity purification|
|Immunogen||Recombinant Human PDK2 protein.|
Target Details PDK2Product Details anti-PDK2 Antibody Application Details Handling References for anti-PDK2 Antibody (ABIN954072) Images back to top
|Alternative Name||PDK2 (PDK2 Antibody Abstract)|
|Background||PDK2 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.Synonyms: Pyruvate dehydrogenase kinase isoform 2, Pyruvate dehydrogenase lipoamide kinase isozyme 2 mitochondrial|
|Molecular Weight||46154 Da|
|Research Area||Cancer, Metabolism|
|Pathways||PI3K-Akt Signaling, RTK Signaling|
Application DetailsProduct Details anti-PDK2 Antibody Target Details PDK2 Handling References for anti-PDK2 Antibody (ABIN954072) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-PDK2 Antibody Target Details PDK2 Application Details References for anti-PDK2 Antibody (ABIN954072) Images back to top
|Buffer||PBS containing 0.09 % (W/V) Sodium Azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-PDK2 Antibody (ABIN954072)Product Details anti-PDK2 Antibody Target Details PDK2 Application Details Handling Images back to top
Li, Kato, Chuang: "Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate." in: The Journal of biological chemistry, Vol. 284, Issue 49, pp. 34458-67, 2009 (PubMed).
Fencl, Janda, Bláhová et al.: "Genotype-phenotype correlation in children with autosomal dominant polycystic kidney disease." in: Pediatric nephrology (Berlin, Germany), Vol. 24, Issue 5, pp. 983-9, 2009 (PubMed).
Sun, Zhou, Chang et al.: "Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 2, pp. 476-84, 2009 (PubMed).
Baker, Hetherington, Reeves et al.: "The rat sperm proteome characterized via IPG strip prefractionation and LC-MS/MS identification." in: Proteomics, Vol. 8, Issue 11, pp. 2312-21, 2008 (PubMed).
ImagesProduct Details anti-PDK2 Antibody Target Details PDK2 Application Details Handling References for anti-PDK2 Antibody (ABIN954072) back to top