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Browse our PDK2 Proteins (PDK2)

Full name:
Pyruvate Dehydrogenase Kinase, Isozyme 2 Proteins (PDK2)
On www.antibodies-online.com are 6 Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) Proteins from 5 different suppliers available. Additionally we are shipping PDK2 Antibodies (141) and PDK2 Kits (2) and many more products for this protein. A total of 157 PDK2 products are currently listed.
Synonyms:
3j828, MGC52849, MGC132353, PDHK2, Pdk, PDK2, PDKII, zgc:56209
list all proteins Gene Name GeneID UniProt
PDK2 18604 Q9JK42
PDK2 5164 Q15119
Rat PDK2 PDK2 81530 Q64536

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PDK2 Proteins (PDK2) by Origin

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Mouse (Murine) Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) interaction partners

  1. PDK2/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy.

  2. Double-knockout mice with global deletion of PDK2 and PDK4 (show PDK4 Proteins), which results in constitutively activated pyruvate dehydrogenase (show PDP Proteins), preferentially oxidize glucose in muscle.

  3. The final compound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits all four PDK isoforms with IC50 = 0.8 muM for PDK2.

  4. The Pdk4 (show PDK4 Proteins) gene knockdown led to better glucose tolerance than the Pdk2 gene knockdown.

  5. loss of both Pdk2 and Pdk4 (show PDK4 Proteins) attenuated HSC (show FUT1 Proteins) quiescence, glycolysis, and transplantation capacity.

  6. Results established that wild-type p53 (show TP53 Proteins) prevents manifestation of the Warburg effect by controlling Pdk2. These findings elucidate a new mechanism by which p53 (show TP53 Proteins) suppresses tumorigenesis acting at the level of cancer cell metabolism.

  7. PDK2 activity is essential, even at rest, in regulation of carbohydrate oxidation and production of reducing equivalents for the electron transport chain.

  8. mitochondrial ND2 mutation contributes to HIF1alpha (show HIF1A Proteins) accumulation via increased ROS (show ROS1 Proteins) production, up-regulation of PDK2, attenuating PDH (show PDP Proteins) activity, thereby increasing pyruvate, resulting in HIF1alpha (show HIF1A Proteins) stabilization

Human Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2) interaction partners

  1. High glycolysis and PDK2 overexpression are closely linked to cisplatin resistance in head and neck cancer cells, which can be reversed by PDK2 nhibition.

  2. both PDK 1 (show PDK1 Proteins) and 2 isoforms are overexpressed in cutaneous melanoma compared to nevi, this expression being associated with the expression of the mTOR (show FRAP1 Proteins) pathway effectors and independent of the BRAF (show BRAF Proteins) mutational status

  3. The findings of the present study reveal a novel survival pathway that functionally couples the unique glycolytic phenotype in cancer cells to hypoxia resistance via a PDK2-dependent mechanism that switches Bnip3 (show BNIP3 Proteins) from cell death to survival.

  4. The final compound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits all four PDK isoforms with IC50 = 0.8 muM for PDK2.

  5. Germline mutations in PKD2 (show PKD2 Proteins) gene is associated with autosomal-dominant polycystic kidney disease.

  6. we for the first time demonstrated that a low-nutrient condition drives cancer cells to utilize glycolysis to produce ATP, and this increases the Warburg effect through a novel mechanism involving ROS (show ROS1 Proteins)/AMPK (show PRKAA1 Proteins)-dependent activation of PDK.

  7. Mitochondrial activation by inhibition of PDKII suppresses HIF1a (show HIF1A Proteins) signaling and angiogenesis in cancer.

  8. Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species.

  9. Results established that wild-type p53 (show TP53 Proteins) prevents manifestation of the Warburg effect by controlling Pdk2. These findings elucidate a new mechanism by which p53 (show TP53 Proteins) suppresses tumorigenesis acting at the level of cancer cell metabolism.

  10. PKD2 (show PKD2 Proteins) mutations are associated with autosomal dominant polycystic kidney disease.

PDK2 Protein Profile

Protein Summary

This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with PDK2

  • pyruvate dehydrogenase kinase, isozyme 4 (pdk4)
  • pyruvate dehydrogenase kinase, isoenzyme 2 (pdk2)
  • pyruvate dehydrogenase kinase, isozyme 2 (PDK2)
  • pyruvate dehydrogenase kinase, isoenzyme 2 (Pdk2)
  • pyruvate dehydrogenase kinase, isozyme 2 (Pdk2)
  • 3j828 protein
  • MGC52849 protein
  • MGC132353 protein
  • PDHK2 protein
  • Pdk protein
  • PDK2 protein
  • PDKII protein
  • zgc:56209 protein

Protein level used designations for PDK2

pyruvate dehydrogenase kinase 2 , pyruvate dehydrogenase kinase, isoenzyme 2 , [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial , pyruvate dehydrogenase kinase, isozyme 2 , PDH kinase 2 , pyruvate dehydrogenase 2 , pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial , PDK P45 , pyruvate dehydrogenase kinase 2 subunit p45 (PDK2)

GENE ID SPECIES
379789 Xenopus laevis
393971 Danio rerio
468402 Pan troglodytes
18604 Mus musculus
5164 Homo sapiens
81530 Rattus norvegicus
524075 Bos taurus
100516037 Sus scrofa
491075 Canis lupus familiaris
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