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anti-Mouse (Murine) PDK4 Antibodies:
anti-Human PDK4 Antibodies:
anti-Rat (Rattus) PDK4 Antibodies:
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Human Polyclonal PDK4 Primary Antibody for IF, IHC (p) - ABIN391039
Attia, Connnaughton, Boone, Wang, Elam, Ness, Cook, Park: Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha). in The Journal of biological chemistry 2010
Show all 17 Pubmed References
Human Polyclonal PDK4 Primary Antibody for ICC, IF - ABIN446469
Connaughton, Chowdhury, Attia, Song, Zhang, Elam, Cook, Park: Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin. in Molecular and cellular endocrinology 2010
Show all 7 Pubmed References
Human Polyclonal PDK4 Primary Antibody for ELISA, WB - ABIN562163
Stenson, Rydén, Steffensen, Wåhlén, Pettersson, Jocken, Arner, Laurencikiene: Activation of liver X receptor regulates substrate oxidation in white adipocytes. in Endocrinology 2009
Show all 3 Pubmed References
Human Monoclonal PDK4 Primary Antibody for ELISA - ABIN518762
Harada, Kakuda, Sato, Ikeda, Shimoda, Yamamoto, Inoue, Ohta, Kasashima, Kawashima, Nakanuma: Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. in Journal of clinical pathology 2014
Show all 2 Pubmed References
Human Polyclonal PDK4 Primary Antibody for ICC, IF - ABIN446476
Necela, Axenfeld, Serie, Kachergus, Perez, Thompson, Norton: The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes. in Clinical and translational medicine 2017
Cow (Bovine) Polyclonal PDK4 Primary Antibody for IHC, WB - ABIN2777592
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
Show all 2 Pubmed References
In conclusion, our data indicated that PDK4 potentially contributes to the hepatic steatosis in NASH (show SAMSN1 Antibodies) via regulating several signaling pathway and PDK4 may be a new therapeutic strategy against NAFLD (show TSC2 Antibodies).
our results suggest that PDK2 (show PDK2 Antibodies)/4 can be a potential target for the development of pharmacotherapy for the treatment of acute inflammatory pain
Taken together these data support a model where PDHK4 regulates KRAS signalling and its tumorigenic properties and suggest that inhibition of PDHK4 could represent a novel therapeutic strategy to target KRAS mutant colorectal and lung cancers
PDK4 mediates cisplatin-induced acute kidney injury.
Pyruvate dehydrogenase kinase 4 is a direct transcriptional target of FoxO1 (show FOXO1 Antibodies) in the heart. FoxO1 (show FOXO1 Antibodies) directly regulates Pdk4 transcription in the heart, thereby controlling PDH (show PDP Antibodies) activity and subsequent glucose oxidation rates.
inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Antibodies), cyclin A2 (show CCNA2 Antibodies), and E2F1 (show E2F1 Antibodies) proteins.
FXR (show NR1H4 Antibodies) may promote the proliferation of tumor cells and the hepatocytes in the process of liver regeneration by activating the PDK4-mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass generation, establishing a mechanistic link between cell proliferation and metabolic switch.
Taken together, our results suggest that LPS (show TLR4 Antibodies) induces PDK4 expression and alters glucose metabolism via the JNK (show MAPK8 Antibodies) pathway.
upregulation of PDK4 promotes vascular calcification by increasing osteogenic markers with no adverse effect on bone formation, demonstrating that PDK4 is a therapeutic target for vascular calcification.
PDK2 (show PDK2 Antibodies)/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy.
Low PDK4 expression is associated with lung tumorigenesis.
Increased PDK4 expression is associated with colon cancer.
We found that PDK4 gene and protein expression was significantly elevated in pulmonary arterial hypertension pericytes and correlated with reduced mitochondrial metabolism, higher rates of glycolysis, and hyperproliferation
Inhibition of CK2 (show CSNK2A1 Antibodies) increased the expression of metabolic regulators, PDK4 and AMPK (show PRKAA1 Antibodies) along with the key cellular energy sensor CREB (show CREB1 Antibodies).
These findings indicate that the TGFbeta (show TGFB1 Antibodies)/PDK4 signaling axis plays an important role in the response of colorectal cancer to chemotherapy.
Combined speed endurance and endurance exercise amplify the exercise-induced PGC-1alpha (show PPARGC1A Antibodies) and PDK4 mRNA response in trained human muscle.
High PDK4 expression is associated with hepatocellular cancer.
Preoperative carbohydrate supplementation was found to ameliorate postoperative insulin (show INS Antibodies) sensitivity by reducing muscle inflammatory responses and improved insulin (show INS Antibodies) inhibition of FOXO1 (show FOXO1 Antibodies)-mediated PDK4 mRNA and protein expression after surgery.
Temporal and spatial expression analysis indicated that porcine PDK4 gene is highly expressed in skeletal muscle and the highest in neonatal pigs.
This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.
pyruvate dehydrogenase kinase 4
, pyruvate dehydrogenase kinase, isoenzyme 4
, pyruvate dehydrogenase kinase, isozyme 4
, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
, pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial
, pyruvate dehydrogenase kinase isozyme 4
, pyruvate dehydrogenate kinase 4