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Browse our PDK4 (PDK4) ELISA Kits

Full name:
Pyruvate Dehydrogenase Kinase, Isozyme 4 ELISA Kits (PDK4)
On www.antibodies-online.com are 33 Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) ELISA Kits from 5 different suppliers available. Additionally we are shipping PDK4 Antibodies (154) and PDK4 Proteins (8) and many more products for this protein. A total of 204 PDK4 products are currently listed.
Synonyms:
AV005916

More ELISA Kits for PDK4 Interaction Partners

Mouse (Murine) Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) interaction partners

  1. PDK2 (show PDK2 ELISA Kits)/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy.

  2. Double-knockout mice with global deletion of PDK2 (show PDK2 ELISA Kits) and PDK4, which results in constitutively activated pyruvate dehydrogenase (show PDP ELISA Kits), preferentially oxidize glucose in muscle.

  3. PDK4 promotes tumorigenesis through activation of the CREB (show CREB1 ELISA Kits)-RHEB (show RHEB ELISA Kits)-mTORC1 signaling cascade.

  4. Diminished insulin (show INS ELISA Kits) signaling evident at 1 wk on the high fat diet did not occur in pyruvate dehydrogenase kinase 4 knockout mice.

  5. The Pdk4 gene knockdown led to better glucose tolerance than the Pdk2 (show PDK2 ELISA Kits) gene knockdown. Hepatic Pdk4 may be critically involved in the pathogenesis of diabetes.

  6. These results suggest a role for PDK4 in regulating the PDH (show PDP ELISA Kits) complex in muscle and promoting gluconeogenic precursor recirculation during recovery from exhaustive exercise.

  7. loss of both Pdk2 (show PDK2 ELISA Kits) and Pdk4 attenuated HSC (show FUT1 ELISA Kits) quiescence, glycolysis, and transplantation capacity.

  8. Deletion of PDK4 prevented Angiotensin II-induced diastolic dysfunction and normalized glucose oxidation to basal levels.

  9. the role of IL-6 (show IL6 ELISA Kits) signalling in adipose tissue during exercise

  10. Data suggest that up-regulation of cardiac PDK4 by high-fat diet (HFD) occurs in conjunction with time-dependent activation of E2F1 transcription factor (E2F1 (show E2F1 ELISA Kits)); HFD may initiate early cardiac metabolic alterations through cyclin D1 (show CCND1 ELISA Kits)/E2F1 (show E2F1 ELISA Kits)/PDK4 axis.

Human Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) interaction partners

  1. Fatty acids induce the expression of PDK4 mRNA, which was increased in myotubes cultured from obese and T2DM donors.

  2. Swiss PDB Viewer identifies NFkappaB (show NFKB1 ELISA Kits) subunit p100 (show CUX1 ELISA Kits)/p49 (show PRIM1 ELISA Kits) as a potential interacting partner for PDK4. Relationship between PDK4 and apoptosis is suggested.

  3. ZBTB2 may increase cell proliferation by reprogramming glucose metabolic pathways to favor glycolysis by upregulating PDK4 expression via repression of RelA/p65 (show NFkBP65 ELISA Kits) expression

  4. Methylation increased in PDK4, IL1 B (show IL1B ELISA Kits), IL6 (show IL6 ELISA Kits), and TNF (show TNF ELISA Kits) promoters 12 months after gastric bypass.

  5. PDK4 promotes tumorigenesis through activation of the CREB (show CREB1 ELISA Kits)-RHEB (show RHEB ELISA Kits)-mTORC1 signaling cascade.

  6. Data show that the orphan nuclear receptor (show ESRRB ELISA Kits) estrogen related receptor gamma (ERRgamma (show ESRRG ELISA Kits)) plays a critical role in hypoxia-mediated activation of pyruvate dehydrogenase kinase 4 (PDK4) gene expression.

  7. mRNA of PGC-1alpha (show PPARGC1A ELISA Kits) and PDK4 increases markedly in both type I and type II skeletal muscle after either continuous or interval exercise

  8. PDK4 polymorphisms may not be associated with type 2 diabetes or metabolic syndrome.

  9. The present structures demonstrate the flexible and dynamic aspects of PDK4 in the open conformation and provide a basis for the development of novel inhibitors targeting the nucleotide-binding pocket of PDK4.

  10. Data show that overexpression of ErbB2 (show ERBB2 ELISA Kits) maintains PDH (show PDP ELISA Kits) flux by suppressing PDK4 expression in an Erk (show EPHB2 ELISA Kits)-dependent manner.

Pig (Porcine) Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) interaction partners

  1. Temporal and spatial expression analysis indicated that porcine PDK4 gene is highly expressed in skeletal muscle and the highest in neonatal pigs.

PDK4 Antigen Profile

Antigen Summary

This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.

Alternative names and synonyms associated with PDK4

  • pyruvate dehydrogenase kinase, isozyme 4 (pdk4) Elisa Kit
  • pyruvate dehydrogenase kinase, isozyme 4 (LOC100230570) Elisa Kit
  • pyruvate dehydrogenase kinase, isoenzyme 4 (Pdk4) Elisa Kit
  • pyruvate dehydrogenase kinase, isozyme 4 (PDK4) Elisa Kit
  • pyruvate dehydrogenase kinase, isozyme 4 (Pdk4) Elisa Kit
  • AV005916 Elisa Kit

Protein level used designations for PDK4

pyruvate dehydrogenase kinase 4 , pyruvate dehydrogenase kinase, isoenzyme 4 , pyruvate dehydrogenase kinase, isozyme 4 , [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial , pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial , pyruvate dehydrogenase kinase isozyme 4 , pyruvate dehydrogenate kinase 4

GENE ID SPECIES
448511 Xenopus (Silurana) tropicalis
100230570 Taeniopygia guttata
27273 Mus musculus
5166 Homo sapiens
482310 Canis lupus familiaris
100286778 Sus scrofa
507367 Bos taurus
89813 Rattus norvegicus
100351580 Oryctolagus cuniculus
420570 Gallus gallus
101117752 Ovis aries
100735301 Cavia porcellus
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