Browse our PDK4 Proteins (PDK4)

Full name:
Pyruvate Dehydrogenase Kinase, Isozyme 4 Proteins (PDK4)
On www.antibodies-online.com are 9 Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) Proteins from 5 different suppliers available. Additionally we are shipping PDK4 Antibodies (174) and PDK4 Kits (32) and many more products for this protein. A total of 224 PDK4 products are currently listed.
Synonyms:
AV005916
list all proteins Gene Name GeneID UniProt
PDK4 27273 O70571
PDK4 5166 Q16654
Rat PDK4 PDK4 89813 O54937

Show all synonyms

PDK4 Proteins (PDK4) by Origin

Select your origin of interest

More Proteins for PDK4 Interaction Partners

Mouse (Murine) Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) interaction partners

  1. Pyruvate dehydrogenase kinase 4 is a direct transcriptional target of FoxO1 (show FOXO1 Proteins) in the heart. FoxO1 (show FOXO1 Proteins) directly regulates Pdk4 transcription in the heart, thereby controlling PDH (show PDP Proteins) activity and subsequent glucose oxidation rates.

  2. inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Proteins), cyclin A2 (show CCNA2 Proteins), and E2F1 (show E2F1 Proteins) proteins.

  3. FXR (show NR1H4 Proteins) may promote the proliferation of tumor cells and the hepatocytes in the process of liver regeneration by activating the PDK4-mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass generation, establishing a mechanistic link between cell proliferation and metabolic switch.

  4. Taken together, our results suggest that LPS (show TLR4 Proteins) induces PDK4 expression and alters glucose metabolism via the JNK (show MAPK8 Proteins) pathway.

  5. upregulation of PDK4 promotes vascular calcification by increasing osteogenic markers with no adverse effect on bone formation, demonstrating that PDK4 is a therapeutic target for vascular calcification.

  6. PDK2 (show PDK2 Proteins)/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy.

  7. Double-knockout mice with global deletion of PDK2 (show PDK2 Proteins) and PDK4, which results in constitutively activated pyruvate dehydrogenase (show PDP Proteins), preferentially oxidize glucose in muscle.

  8. PDK4 promotes tumorigenesis through activation of the CREB (show CREB1 Proteins)-RHEB (show RHEB Proteins)-mTORC1 signaling cascade.

  9. Diminished insulin (show INS Proteins) signaling evident at 1 wk on the high fat diet did not occur in pyruvate dehydrogenase kinase 4 knockout mice.

  10. The Pdk4 gene knockdown led to better glucose tolerance than the Pdk2 (show PDK2 Proteins) gene knockdown. Hepatic Pdk4 may be critically involved in the pathogenesis of diabetes.

Human Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) interaction partners

  1. Low PDK4 expression is associated with lung tumorigenesis.

  2. Increased PDK4 expression is associated with colon cancer.

  3. We found that PDK4 gene and protein expression was significantly elevated in pulmonary arterial hypertension pericytes and correlated with reduced mitochondrial metabolism, higher rates of glycolysis, and hyperproliferation

  4. Inhibition of CK2 (show CSNK2A1 Proteins) increased the expression of metabolic regulators, PDK4 and AMPK (show PRKAA1 Proteins) along with the key cellular energy sensor CREB (show CREB1 Proteins).

  5. These findings indicate that the TGFbeta (show TGFB1 Proteins)/PDK4 signaling axis plays an important role in the response of colorectal cancer to chemotherapy.

  6. inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Proteins), cyclin A2 (show CCNA2 Proteins), and E2F1 (show E2F1 Proteins) proteins.

  7. FXR (show NR1H4 Proteins) may promote the proliferation of tumor cells and the hepatocytes in the process of liver regeneration by activating the PDK4-mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass generation, establishing a mechanistic link between cell proliferation and metabolic switch.

  8. Combined speed endurance and endurance exercise amplify the exercise-induced PGC-1alpha and PDK4 mRNA response in trained human muscle.

  9. High PDK4 expression is associated with hepatocellular cancer.

  10. upregulation of PDK4 promotes vascular calcification by increasing osteogenic markers with no adverse effect on bone formation, demonstrating that PDK4 is a therapeutic target for vascular calcification.

Pig (Porcine) Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) interaction partners

  1. Preoperative carbohydrate supplementation was found to ameliorate postoperative insulin (show INS Proteins) sensitivity by reducing muscle inflammatory responses and improved insulin (show INS Proteins) inhibition of FOXO1 (show FOXO1 Proteins)-mediated PDK4 mRNA and protein expression after surgery.

  2. Temporal and spatial expression analysis indicated that porcine PDK4 gene is highly expressed in skeletal muscle and the highest in neonatal pigs.

PDK4 Protein Profile

Protein Summary

This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.

Alternative names and synonyms associated with PDK4

  • pyruvate dehydrogenase kinase, isozyme 4 (pdk4)
  • pyruvate dehydrogenase kinase, isozyme 4 (LOC100230570)
  • pyruvate dehydrogenase kinase, isoenzyme 4 (Pdk4)
  • pyruvate dehydrogenase kinase, isozyme 4 (PDK4)
  • pyruvate dehydrogenase kinase, isozyme 4 (Pdk4)
  • AV005916 protein

Protein level used designations for PDK4

pyruvate dehydrogenase kinase 4 , pyruvate dehydrogenase kinase, isoenzyme 4 , pyruvate dehydrogenase kinase, isozyme 4 , [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial , pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial , pyruvate dehydrogenase kinase isozyme 4 , pyruvate dehydrogenate kinase 4

GENE ID SPECIES
448511 Xenopus (Silurana) tropicalis
100230570 Taeniopygia guttata
27273 Mus musculus
5166 Homo sapiens
482310 Canis lupus familiaris
100286778 Sus scrofa
507367 Bos taurus
89813 Rattus norvegicus
100351580 Oryctolagus cuniculus
420570 Gallus gallus
101117752 Ovis aries
100735301 Cavia porcellus
Selected quality suppliers for PDK4 Proteins (PDK4)
Did you look for something else?