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Browse our PDK4 Proteins (PDK4)

Full name:
Pyruvate Dehydrogenase Kinase, Isozyme 4 Proteins (PDK4)
On www.antibodies-online.com are 8 Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) Proteins from 5 different suppliers available. Additionally we are shipping PDK4 Antibodies (141) and PDK4 Kits (33) and many more products for this protein. A total of 191 PDK4 products are currently listed.
Synonyms:
AV005916
list all proteins Gene Name GeneID UniProt
PDK4 27273 O70571
PDK4 5166 Q16654
Rat PDK4 PDK4 89813 O54937

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PDK4 Proteins (PDK4) by Origin

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More Proteins for PDK4 Interaction Partners

Mouse (Murine) Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) interaction partners

  1. Taken together, our results suggest that LPS (show TLR4 Proteins) induces PDK4 expression and alters glucose metabolism via the JNK (show MAPK8 Proteins) pathway.

  2. upregulation of PDK4 promotes vascular calcification by increasing osteogenic markers with no adverse effect on bone formation, demonstrating that PDK4 is a therapeutic target for vascular calcification.

  3. PDK2 (show PDK2 Proteins)/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy.

  4. Double-knockout mice with global deletion of PDK2 (show PDK2 Proteins) and PDK4, which results in constitutively activated pyruvate dehydrogenase (show PDP Proteins), preferentially oxidize glucose in muscle.

  5. PDK4 promotes tumorigenesis through activation of the CREB (show CREB1 Proteins)-RHEB (show RHEB Proteins)-mTORC1 signaling cascade.

  6. Diminished insulin (show INS Proteins) signaling evident at 1 wk on the high fat diet did not occur in pyruvate dehydrogenase kinase 4 knockout mice.

  7. The Pdk4 gene knockdown led to better glucose tolerance than the Pdk2 (show PDK2 Proteins) gene knockdown. Hepatic Pdk4 may be critically involved in the pathogenesis of diabetes.

  8. These results suggest a role for PDK4 in regulating the PDH (show PDP Proteins) complex in muscle and promoting gluconeogenic precursor recirculation during recovery from exhaustive exercise.

  9. loss of both Pdk2 (show PDK2 Proteins) and Pdk4 attenuated HSC (show FUT1 Proteins) quiescence, glycolysis, and transplantation capacity.

  10. Deletion of PDK4 prevented Angiotensin II-induced diastolic dysfunction and normalized glucose oxidation to basal levels.

Human Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) interaction partners

  1. Combined speed endurance and endurance exercise amplify the exercise-induced PGC-1alpha and PDK4 mRNA response in trained human muscle.

  2. High PDK4 expression is associated with hepatocellular cancer.

  3. upregulation of PDK4 promotes vascular calcification by increasing osteogenic markers with no adverse effect on bone formation, demonstrating that PDK4 is a therapeutic target for vascular calcification.

  4. Fatty acids induce the expression of PDK4 mRNA, which was increased in myotubes cultured from obese and T2DM donors.

  5. Swiss PDB Viewer identifies NFkappaB (show NFKB1 Proteins) subunit p100 (show CUX1 Proteins)/p49 (show PRIM1 Proteins) as a potential interacting partner for PDK4. Relationship between PDK4 and apoptosis is suggested.

  6. ZBTB2 (show ZBTB2 Proteins) may increase cell proliferation by reprogramming glucose metabolic pathways to favor glycolysis by upregulating PDK4 expression via repression of RelA/p65 (show NFkBP65 Proteins) expression

  7. Methylation increased in PDK4, IL1 B (show IL1B Proteins), IL6 (show IL6 Proteins), and TNF (show TNF Proteins) promoters 12 months after gastric bypass.

  8. PDK4 promotes tumorigenesis through activation of the CREB (show CREB1 Proteins)-RHEB (show RHEB Proteins)-mTORC1 signaling cascade.

  9. Data show that the orphan nuclear receptor estrogen related receptor gamma (ERRgamma (show ESRRG Proteins)) plays a critical role in hypoxia-mediated activation of pyruvate dehydrogenase kinase 4 (PDK4) gene expression.

  10. mRNA of PGC-1alpha and PDK4 increases markedly in both type I and type II skeletal muscle after either continuous or interval exercise

Pig (Porcine) Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) interaction partners

  1. Preoperative carbohydrate supplementation was found to ameliorate postoperative insulin (show INS Proteins) sensitivity by reducing muscle inflammatory responses and improved insulin (show INS Proteins) inhibition of FOXO1 (show FOXO1 Proteins)-mediated PDK4 mRNA and protein expression after surgery.

  2. Temporal and spatial expression analysis indicated that porcine PDK4 gene is highly expressed in skeletal muscle and the highest in neonatal pigs.

PDK4 Protein Profile

Protein Summary

This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.

Alternative names and synonyms associated with PDK4

  • pyruvate dehydrogenase kinase, isozyme 4 (pdk4)
  • pyruvate dehydrogenase kinase, isozyme 4 (LOC100230570)
  • pyruvate dehydrogenase kinase, isoenzyme 4 (Pdk4)
  • pyruvate dehydrogenase kinase, isozyme 4 (PDK4)
  • pyruvate dehydrogenase kinase, isozyme 4 (Pdk4)
  • AV005916 protein

Protein level used designations for PDK4

pyruvate dehydrogenase kinase 4 , pyruvate dehydrogenase kinase, isoenzyme 4 , pyruvate dehydrogenase kinase, isozyme 4 , [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial , pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial , pyruvate dehydrogenase kinase isozyme 4 , pyruvate dehydrogenate kinase 4

GENE ID SPECIES
448511 Xenopus (Silurana) tropicalis
100230570 Taeniopygia guttata
27273 Mus musculus
5166 Homo sapiens
482310 Canis lupus familiaris
100286778 Sus scrofa
507367 Bos taurus
89813 Rattus norvegicus
100351580 Oryctolagus cuniculus
420570 Gallus gallus
101117752 Ovis aries
100735301 Cavia porcellus
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