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On www.antibodies-online.com are 25 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) ELISA Kits from 10 different suppliers available. Additionally we are shipping PDPK1 Antibodies (467) and PDPK1 Proteins (28) and many more products for this protein. A total of 551 PDPK1 products are currently listed.
Synonyms:
1210, BG02759, CG1201, CG1210, Dmel\\CG1210, dPDK-1, dPDK1, dSTPK61, MGC82080, PDK, PDK-1, Pdk1, PDK1/Pk61C, pdpk1, PDPK2, pk61c, Pk61C/PDK1, PRO0461, zgc:153787
list all ELISA KIts Gene Name GeneID UniProt
PDPK1 81745 O55173
PDPK1 5170 O15530
PDPK1 18607 Q9Z2A0

PDPK1 (PDPK1) ELISA Kits by Reactivity

More ELISA Kits for PDPK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. PDK1 is also a presynaptic protein, though it is distributed more broadly.

  2. dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (show CDK7 ELISA Kits) 1, dPDK1

Mouse (Murine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.

  2. PDK1 was highly expressed in synovia of collagen-induced-arthritis mice com (show IL1B ELISA Kits)pared to (show IL6 ELISA Kits)control. The expressions of PDK1, p-PDK1, RSK2 and p-RSK2 were all up- (show RPS6KA3 ELISA Kits)regulated in CIA compared with normal. This indicated that PDK1/RSK2 may participate in inflammatory pro (show TNF ELISA Kits)gress of RA.

  3. PDK1 is required for Ca(2 (show CA2 ELISA Kits)+)-dependent platelet activation on stimulation of collagen receptor (show ITGA2 ELISA Kits) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.

  4. In conclusion, we have identified that ARL15 acts as an insulin (show INS ELISA Kits)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 ELISA Kits)/PDPK1/AKT (show AKT1 ELISA Kits) insulin (show INS ELISA Kits) pathway by interacting with its GAP ASAP2 (show ASAP2 ELISA Kits) and activating PDPK1. This research may provide new insights into GTPase (show RACGAP1 ELISA Kits)-mediated insulin (show INS ELISA Kits) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS ELISA Kits) sensitizati

  5. Only when suboptimal doses of Akt (show AKT1 ELISA Kits)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (show NOTCH1 ELISA Kits) inhibition was seen. We conclude that the Akt (show AKT1 ELISA Kits) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (show AKT1 ELISA Kits) signaling.

  6. Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (show NFKB1 ELISA Kits).

  7. PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.

  8. The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.

  9. PDK1 is an important regulator in arterial thrombosis formation.

  10. PDK1 is essential for BCR (show BCR ELISA Kits)-induced signal transduction to Foxo (show FOXO3 ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) and is indispensable for both resting and activated B cell survival.

Human 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Highly expressed PDK1 (show PDK1 ELISA Kits) could promote cell invasion and secretion of IL-1beta (show IL1B ELISA Kits) and IL-6 (show IL6 ELISA Kits) in human rheumatoid arthritis synovial MH7A cells. Inhibition of RSK2 (show RPS6KA3 ELISA Kits) reduced the PDK1 (show PDK1 ELISA Kits)-induced cell invasion and cytokines secretion in MH7A cells. In response to TNF-alpha (show TNF ELISA Kits), PDK1 (show PDK1 ELISA Kits) could phosphorylate RSK2 (show RPS6KA3 ELISA Kits) and activated RSK2 (show RPS6KA3 ELISA Kits), then promoting the activation of NF-kappaB (show NFKB1 ELISA Kits).

  2. In cancer cells resistant to PI3Kalpha (show PIK3CA ELISA Kits) inhibition, PDK1 (show PDK1 ELISA Kits) blockade restores sensitivity to these therapies. SGK1 (show SGK1 ELISA Kits), which is activated by PDK1 (show PDK1 ELISA Kits), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (show TSC2 ELISA Kits).

  3. Results suggest that Ser (show SIGLEC1 ELISA Kits)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (show PDK1 ELISA Kits)-PKCtheta (show PRKCQ ELISA Kits);-mediated T cell activation.

  4. Elevated expression of PDK1 (show PDK1 ELISA Kits) was an independent negative prognostic factor of gastric carcinoma.

  5. miR (show MLXIP ELISA Kits)-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1 (show PDK1 ELISA Kits).

  6. miR (show MLXIP ELISA Kits)-454 functions as a tumor suppressor in glioblastoma, inhibiting proliferation of human glioblastoma cells by suppressing PDK1 (show PDK1 ELISA Kits) expression.

  7. Decreased PDK1 (show PDK1 ELISA Kits) level is closely associated with reduced Akt (show AKT1 ELISA Kits)/cyclin D1 (show CCND1 ELISA Kits) activity.

  8. MiR (show MLXIP ELISA Kits)-138 regulation of PI3K (show PIK3CA ELISA Kits) signaling in ASMCs by altering the expression of PDK1 (show PDK1 ELISA Kits).

  9. Dephosphorylation of PDK-1 (show PDK1 ELISA Kits) and the resulting changes to Akt (show AKT1 ELISA Kits) phosphorylation is one of the mechanisms by which infection with Helicobacter pylori alter the balance between apoptosis and cell proliferation.

  10. Data suggest that claudin-18 (show CLDN18 ELISA Kits) suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of phosphoinositide-dependent protein kinase (show CDK7 ELISA Kits)-1 and proto-oncogene (show RAB1A ELISA Kits) protein c (show PROC ELISA Kits)-akt (Akt (show AKT1 ELISA Kits)).

Pig (Porcine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. miR (show MYLIP ELISA Kits)-375 directly targeted PDK1 (show PDK1 ELISA Kits) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.

Caenorhabditis elegans (C. elegans) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (show PIK3C3 ELISA Kits) (PI3K)

PDPK1 Antigen Profile

Antigen Summary

Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.

Alternative names and synonyms associated with PDPK1

  • 3-phosphoinositide dependent protein kinase-1 (PDPK1) Elisa Kit
  • 3-phosphoinositide dependent protein kinase-1 (pdpk1) Elisa Kit
  • 3-phosphoinositide dependent protein kinase-1 (Pdpk1) Elisa Kit
  • 3-phosphoinositide dependent protein kinase 1 (Pdpk1) Elisa Kit
  • 3-phosphoinositide dependent protein kinase-1a (pdpk1a) Elisa Kit
  • 3-phosphoinositide-dependent protein kinase 1 (pdpk1) Elisa Kit
  • Phosphoinositide-dependent kinase 1 (Pdk1) Elisa Kit
  • Protein PDK-1 (pdk-1) Elisa Kit
  • 1210 Elisa Kit
  • BG02759 Elisa Kit
  • CG1201 Elisa Kit
  • CG1210 Elisa Kit
  • Dmel\\CG1210 Elisa Kit
  • dPDK-1 Elisa Kit
  • dPDK1 Elisa Kit
  • dSTPK61 Elisa Kit
  • MGC82080 Elisa Kit
  • PDK Elisa Kit
  • PDK-1 Elisa Kit
  • Pdk1 Elisa Kit
  • PDK1/Pk61C Elisa Kit
  • pdpk1 Elisa Kit
  • PDPK2 Elisa Kit
  • pk61c Elisa Kit
  • Pk61C/PDK1 Elisa Kit
  • PRO0461 Elisa Kit
  • zgc:153787 Elisa Kit

Protein level used designations for PDPK1

3-phosphoinositide-dependent protein kinase 1 , 3-phosphoinositide dependent protein kinase-1 , pkB kinase , protein kinase B kinase , PkB kinase like gene 1 , Pkb kinase , mPDK1 , CG1210-PA , CG1210-PB , CG1210-PC , CG1210-PD , CG1210-PE , CG1210-PF , CG1210-PG , CG1210-PH , CG1210-PI , CG1210-PJ , Pdk1-PA , Pdk1-PB , Pdk1-PC , Pdk1-PD , Pdk1-PE , Pdk1-PF , Pdk1-PG , Pdk1-PH , Pdk1-PI , Pdk1-PJ , phosphoinositide dependent kinase 1 , phosphoinositide-dependent kinase 1 , protein kinase 61C , serine/threonine protein kinase

GENE ID SPECIES
416588 Gallus gallus
444529 Xenopus laevis
479875 Canis lupus familiaris
100138102 Bos taurus
100192445 Sus scrofa
779524 Xenopus (Silurana) tropicalis
81745 Rattus norvegicus
5170 Homo sapiens
18607 Mus musculus
768202 Danio rerio
100380750 Salmo salar
38017 Drosophila melanogaster
180475 Caenorhabditis elegans
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