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Browse our PFKFB2 Proteins (PFKFB2)

Full name:
6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 2 Proteins (PFKFB2)
On www.antibodies-online.com are 7 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 2 (PFKFB2) Proteins from 5 different suppliers available. Additionally we are shipping PFKFB2 Antibodies (92) and PFKFB2 Kits (8) and many more products for this protein. A total of 121 PFKFB2 products are currently listed.
Synonyms:
4930568D07Rik, PFK-2/FBPase-2, pfkfb2, RH2K, zgc:56282
list all proteins Gene Name GeneID UniProt
PFKFB2 5208 O60825
PFKFB2 18640 P70265
PFKFB2 24640 Q9JJH5

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PFKFB2 Proteins (PFKFB2) by Origin

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More Proteins for PFKFB2 Interaction Partners

Human 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 2 (PFKFB2) interaction partners

  1. Variation in PFKFB2 appears to reduce PFKFB2 expression in adipose and kidney tissues, and thereby increase risk for adiposity and diabetic nephropathy.

  2. Highly expressed PFKFB2 protein is associated with hepatocellular carcinoma.

  3. bifunctionality of PFK-2/FBPase-2 complements the metabolic zonation of the liver by ensuring coherent switching in response to insulin (show INS Proteins) and glucagon (show GCG Proteins).

  4. amino acids stimulate Fru-2,6-P2 synthesis by Akt (show AKT1 Proteins)-dependent PFKFB2 phosphorylation and activation and show how signaling and metabolism are inextricably linked.

  5. A persistent increase in 6-phosphofructo-2-kinase (show PFKFB3 Proteins) produced by a change in PFK-2/FBPase-2 isoform expression that may play an important role in the regulation of muscle glycolysis.

  6. Suggest that PFKFB2 is not an essential upstream regulator of the anti-leukemic effects of glucocorticoids.

  7. induction of de novo lipid synthesis by androgen requires transcriptional up-regulation of HK2 (show HK2 Proteins) and PFKFB2, and phosphorylation of PFKFB2 generated by the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signal pathway to supply the source for lipogenesis from glucose in prostate cancer cells.

  8. Human islets expressed the PFKFB2 and PFKFB3 isoforms. PFK-2/FBPase-2 protein rather than its product fructose 2,6-P(2) is the over-riding determinant of glucose-induced i (show INS Proteins)nsulin secretion through regulation of gluco (show GCK Proteins)kinase activity

Mouse (Murine) 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 2 (PFKFB2) interaction partners

  1. SGK3 (show SGK3 Proteins) is not required for insulin (show INS Proteins)-induced PFK-2 activation and that this effect is likely mediated by PKBalpha (show AKT1 Proteins).

  2. Our results demonstrate that in diet-induced obesity, high Fru-2,6-P2 levels in transgenic livers caused changes in hepatic gene expression profiles for key gluconeogenic and lipogenic enzymes.

  3. mouse islets expressed PFKFB2 at the mRNA level; PFK-2/FBPase-2 protein rather than its product fructose 2,6-P(2) is the over-riding determinant of glucose-induced insulin (show INS Proteins) secretion through regulation of glucokinase (show GCK Proteins) activity or subcellular targeting.

Cow (Bovine) 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 2 (PFKFB2) interaction partners

  1. SGK3 (show SGK3 Proteins) is not required for insulin (show INS Proteins)-induced PFK-2 activation and that this effect is likely mediated by PKBalpha (show AKT1 Proteins).

PFKFB2 Protein Profile

Protein Summary

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with PFKFB2

  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2a (pfkfb2a)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (pfkfb2)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (Pfkfb2)
  • 4930568D07Rik protein
  • PFK-2/FBPase-2 protein
  • pfkfb2 protein
  • RH2K protein
  • zgc:56282 protein

Protein level used designations for PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 , pfk-2/fbpase-2 , 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2-like , 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 , 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme , 6PF-2-K/Fru-2,6-P2ase 2 , PFK/FBPase 2 , PFKFB, cardiac , fructose-2,6-bisphosphatase, cardiac isozyme , 6PF-2-K/Fru-2,6-P2ase heart-type isozyme , PFK-2/FBPase-2 gene B , 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (heart) , PFK-2/FBPase-2 , fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase , 6-phosphofructo-2-kinase /fructose-2,6-bisphosphatase

GENE ID SPECIES
393983 Danio rerio
457687 Pan troglodytes
693509 Macaca mulatta
100020159 Monodelphis domestica
100051146 Equus caballus
100170160 Xenopus (Silurana) tropicalis
100389023 Callithrix jacchus
100484471 Ailuropoda melanoleuca
100563872 Anolis carolinensis
100585652 Nomascus leucogenys
5208 Homo sapiens
18640 Mus musculus
24640 Rattus norvegicus
480011 Canis lupus familiaris
287019 Bos taurus
419850 Gallus gallus
100174086 Pongo abelii
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