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Browse our anti-PHLPP1 (PHLPP1) Antibodies

Full name:
anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 Antibodies (PHLPP1)
On www.antibodies-online.com are 35 PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) Antibodies from 18 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 42 PHLPP1 products are currently listed.
Synonyms:
AI836256, mKIAA0606, Phlpp, Plekhe1, Scop
list all antibodies Gene Name GeneID UniProt
PHLPP1 23239 O60346
PHLPP1 98432 Q8CHE4
PHLPP1 59265 Q9WTR8

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Most Popular Reactivities for anti-PHLPP1 (PHLPP1) Antibodies

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anti-Human PHLPP1 Antibodies:

anti-Mouse (Murine) PHLPP1 Antibodies:

anti-Rat (Rattus) PHLPP1 Antibodies:

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Top referenced anti-PHLPP1 Antibodies

  1. Human Polyclonal PHLPP1 Primary Antibody for EIA, WB - ABIN360194 : Gao, Brognard, Newton: The phosphatase PHLPP controls the cellular levels of protein kinase C. in The Journal of biological chemistry 2008 (PubMed)
    Show all 3 references for ABIN360194

More Antibodies against PHLPP1 Interaction Partners

Human PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) interaction partners

  1. our results suggest that PHLPP1 plays a crucial role in sacral chordoma

  2. high levels of PHLPP might reflect a less aggressive lung adenocarcinoma phenotype and predict better survival in patients with lung adenocarcinoma.

  3. Results showed that PHLPP1 and PHLPP2 (show PHLPP2 Antibodies) gene expression are down-regulated in esophageal squamous cell carcinoma. Their promotor is a target for mir (show MLXIP Antibodies)-224.

  4. Data show that both serine/threonine phosphatases PHLPP and dephosphorylated the physiological substrates of Akt1 (show AKT1 Antibodies) and Akt3 (show AKT3 Antibodies) with similar efficiencies.

  5. Aberrant expression of PHLPP1 and PHLPP2 (show PHLPP2 Antibodies) correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinoma

  6. PHLPP1, along with miR (show MLXIP Antibodies)-522, promoted tumor cell growth in glioblastoma cells.

  7. Suppression of PHLPP1 by DNA methylation (show HELLS Antibodies) contributes to melanoma development and progression.

  8. miR (show MLXIP Antibodies)-141 and its targets PHLPP1 and PHLPP2 (show PHLPP2 Antibodies) play critical roles in NSCLC tumorigenesis

  9. biochemical characterization of phosphatase domain of PHLPP1 and PHLPP2 (show PHLPP2 Antibodies);PHLPP1 and PHLPP2 (show PHLPP2 Antibodies) have similar in vitro activities and respond comparably to the presence of metallic ions; metallic ions affect structural stability of the domain;identified 3 residues likely involved in metal coordination and 2 that may be important for structural integrity

  10. conclude that cross-talk between PTEN (show PTEN Antibodies) and PHLPPs is silenced in normal prostate cells but activated in TGF-beta1 (show TGFB1 Antibodies) transformed prostate stem and cancer cells and facilitates invasive growth

Mouse (Murine) PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) interaction partners

  1. Phlpp1 deficiency increases Akt2 (show AKT2 Antibodies) activity, which diminishes FoxO1 (show FOXO1 Antibodies) levels and induces Fgf18 (show FGF18 Antibodies) expression to stimulate chondrocyte proliferation.

  2. enhancing Akt (show AKT1 Antibodies) activity by inhibiting its PHLPP1-mediated dephosphorylation promotes processes associated with physiological hypertrophy

  3. data are consistent with a model in which PHLPP modifies the histone code to control the transcription of RTKs.

  4. SRPK1 (show SRPK1 Antibodies) overexpression is also tumorigenic because excess SRPK1 (show SRPK1 Antibodies) squelches PHLPP1.

  5. PHLPP is a negative regulator of RAF1 (show RAF1 Antibodies), which reduces colorectal cancer cell motility and prevents tumor progression in mice.

  6. Histone deacetylase 3 (show HDAC3 Antibodies) suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt (show AKT1 Antibodies) signaling and matrix secretion

  7. deletion of PHLPP1 can enhance Akt (show AKT1 Antibodies) activation in neurons and astrocytes, and can significantly increase cell survival and diminish infarct size

  8. PHLPP1 has tumor suppressive activity and might represent a therapeutic or diagnostic tool for pancreatic ductal adenocarcinoma.

  9. PHLPP as a novel tumor suppressor.

  10. findings show that PH-domain leucine-rich-repeat protein (show LRRC10 Antibodies) phosphatase (PHLPP), which dephosphorylates Akt (show AKT1 Antibodies), is upregulated in Tregs, thus suppressing Akt (show AKT1 Antibodies) activation

PHLPP1 Antigen Profile

Antigen Summary

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.

Alternative names and synonyms associated with PHLPP1

  • PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) antibody
  • PH domain and leucine rich repeat protein phosphatase 1 (phlpp1) antibody
  • PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1) antibody
  • AI836256 antibody
  • mKIAA0606 antibody
  • Phlpp antibody
  • Plekhe1 antibody
  • Scop antibody

Protein level used designations for PHLPP1

PH domain and leucine rich repeat protein phosphatase 1 , PH domain leucine-rich repeat-containing protein phosphatase 1-like , PH domain leucine-rich repeat-containing protein phosphatase 1 , PH domain-containing family E member 1 , SCN circadian oscillatory protein , pleckstrin homology domain containing, family E (with leucine rich repeats) member 1 , suprachiasmatic nucleus circadian oscillatory protein , pleckstrin homology domain-containing family E member 1 , Circadian Oscillatory Protein (SCOP) , PH domain leucine-rich repeat protein phosphatase 1 , pleckstrin homology domain-containing family E protein 1

GENE ID SPECIES
468563 Pan troglodytes
476179 Canis lupus familiaris
705882 Macaca mulatta
100483835 Ailuropoda melanoleuca
100497530 Xenopus (Silurana) tropicalis
100545158 Meleagris gallopavo
23239 Homo sapiens
98432 Mus musculus
59265 Rattus norvegicus
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