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Low PHLPP expression is associated with gallbladder cancer.
nickel exposure results in DNMT3b (show DNMT3B ELISA Kits) induction and MEG3 (show FAM129B ELISA Kits) promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun (show JUN ELISA Kits) and in turn increasing c-Jun (show JUN ELISA Kits) inhibition of PHLPP1 transcription, leading to the Akt (show AKT1 ELISA Kits)/p70S6K (show RPS6KB1 ELISA Kits)/S6 axis activation, and HIF-1alpha (show HIF1A ELISA Kits) protein translation, as well as malignant transformation of human bronchial epithelial cells.
Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41 (show RNF41 ELISA Kits)-mediated SGT1 (show SUGT1 ELISA Kits) degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 (show RNF41 ELISA Kits) = ring finger protein 41 (show RNF41 ELISA Kits); SGT1 (show SUGT1 ELISA Kits) = suppressor of G2 allele of SKP1 (show SUGT1 ELISA Kits))
Studies indicate that two PHLPP isozymes, PHLPP1 and PHLPP2, were identified in a search for phosphatases that dephosphorylate Akt (show AKT1 ELISA Kits), and thus suppress growth factor signaling.
During LPS (show IRF6 ELISA Kits) induced macrophage inflammatory response, PHLPP levels in macrophages are depleted through the inhibition of SP1 (show PSG1 ELISA Kits) dependent transcriptional regulation.
results identify a novel role of PHLPP in regulating aPKC and cell polarity.
Abnormal PHLPP, FoxO3a (show FOXO3 ELISA Kits), and RAD51 (show RAD51 ELISA Kits) protein expressions may be involved in the development of high- and low-grade ovarian serous adenocarcinomas, suggesting common molecular pathways.
this study shows that PHLPP1 played a suppression role in inflammatory response of glioma
Increased PHLPP expression is associated with pancreatic cancer.
our results suggest that PHLPP1 plays a crucial role in sacral chordoma
PHLPP1 reduced IFN-gamma (show IFNG ELISA Kits)-stimulated but not LPS (show TLR4 ELISA Kits)-induced ERK1/2 (show MAPK1/3 ELISA Kits) phosphorylation, and inhibition of ERK1/2 (show MAPK1/3 ELISA Kits) abolished IFN-gamma-induced (show SAMHD1 ELISA Kits) ser (show SIGLEC1 ELISA Kits)(727) STAT1 (show STAT1 ELISA Kits) phosphorylation and iNOS (show NOS2 ELISA Kits) expression.
Phlpp1 deficiency increases Akt2 (show AKT2 ELISA Kits) activity, which diminishes FoxO1 (show FOXO1 ELISA Kits) levels and induces Fgf18 (show FGF18 ELISA Kits) expression to stimulate chondrocyte proliferation.
enhancing Akt (show AKT1 ELISA Kits) activity by inhibiting its PHLPP1-mediated dephosphorylation promotes processes associated with physiological hypertrophy
data are consistent with a model in which PHLPP modifies the histone code to control the transcription of RTKs.
SRPK1 (show SRPK1 ELISA Kits) overexpression is also tumorigenic because excess SRPK1 (show SRPK1 ELISA Kits) squelches PHLPP1.
PHLPP is a negative regulator of RAF1 (show RAF1 ELISA Kits), which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Histone deacetylase 3 (show HDAC3 ELISA Kits) suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt (show AKT1 ELISA Kits) signaling and matrix secretion
deletion of PHLPP1 can enhance Akt (show AKT1 ELISA Kits) activation in neurons and astrocytes, and can significantly increase cell survival and diminish infarct size
PHLPP1 has tumor suppressive activity and might represent a therapeutic or diagnostic tool for pancreatic ductal adenocarcinoma.
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
PH domain and leucine rich repeat protein phosphatase 1
, PH domain leucine-rich repeat-containing protein phosphatase 1-like
, PH domain leucine-rich repeat-containing protein phosphatase 1
, PH domain-containing family E member 1
, SCN circadian oscillatory protein
, pleckstrin homology domain containing, family E (with leucine rich repeats) member 1
, suprachiasmatic nucleus circadian oscillatory protein
, pleckstrin homology domain-containing family E member 1
, Circadian Oscillatory Protein (SCOP)
, PH domain leucine-rich repeat protein phosphatase 1
, pleckstrin homology domain-containing family E protein 1