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anti-Human PHLPP2 Antibodies:
anti-Mouse (Murine) PHLPP2 Antibodies:
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Human Polyclonal PHLPP2 Primary Antibody for IP, WB - ABIN151321
Sangai, Akcakanat, Chen, Tarco, Wu, Do, Miller, Arteaga, Mills, Gonzalez-Angulo, Meric-Bernstam: Biomarkers of response to Akt inhibitor MK-2206 in breast cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Show all 2 Pubmed References
Human Polyclonal PHLPP2 Primary Antibody for ELISA, WB - ABIN253307
Gao, Furnari, Newton: PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. in Molecular cell 2005
two PHLPP (show PHLPP1 Antibodies) isozymes, PHLPP1 (show PHLPP1 Antibodies) and PHLPP2, were identified in a search for phosphatases that dephosphorylate Akt (show AKT1 Antibodies), and thus suppress growth factor signaling.
results identify a novel role of PHLPP (show PHLPP1 Antibodies) in regulating aPKC and cell polarity.
Low PHLPP2 expression is associated with luminal breast cancer.
miR (show MLXIP Antibodies)-3117 contributes to the proliferation of HepG2 by targeting PHLPPL.
Overexpression of PHLPP2 without its 3'UTR (show UTS2R Antibodies) attenuated the effects of miR (show MLXIP Antibodies)-181a on cell proliferation and apoptosis in keloid fibroblast cells.
Suggest that direct PHLPP2 downregulation is required for miR (show MLXIP Antibodies)-32-induced cell proliferation of breast cancer cells.
Our studies not only first time identify PHLPP2 downregulation by lung carcinogen B[a]P/B[a]PDE (show ALDH7A1 Antibodies), but also elucidate a novel molecular mechanisms underlying lung inflammation and carcinogenesis upon B[a]P/B[a]PDE (show ALDH7A1 Antibodies) exposure.
Results showed that PHLPP1 (show PHLPP1 Antibodies) and PHLPP2 gene expression are down-regulated in esophageal squamous cell carcinoma. Their promotor is a target for mir (show MLXIP Antibodies)-224.
Data show that both serine/threonine phosphatases PHLPP (show PHLPP1 Antibodies) and dephosphorylated the physiological substrates of Akt1 (show AKT1 Antibodies) and Akt3 (show AKT3 Antibodies) with similar efficiencies.
Aberrant expression of PHLPP1 (show PHLPP1 Antibodies) and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinoma
PHLPP (show PHLPP1 Antibodies) is a negative regulator of RAF1 (show RAF1 Antibodies), which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
PH domain leucine-rich repeat-containing protein phosphatase 2
, PH domain and leucine rich repeat protein phosphatase 2
, PH domain leucine-rich repeat-containing protein phosphatase 2-like
, GTPase activating protein and VPS9 domains 1