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Browse our PHLPP2 Proteins (PHLPP2)

Full name:
PH Domain and Leucine Rich Repeat Protein Phosphatase 2 Proteins (PHLPP2)
On www.antibodies-online.com are 4 PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) Proteins from 3 different suppliers available. Additionally we are shipping PHLPP2 Antibodies (40) and many more products for this protein. A total of 49 PHLPP2 products are currently listed.
Synonyms:
AI481772, C130044A18Rik, Phlppl, RGD1562857
list all proteins Gene Name GeneID UniProt
PHLPP2 23035 Q6ZVD8
PHLPP2 244650 Q8BXA7
Rat PHLPP2 PHLPP2 498949  

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PHLPP2 Proteins (PHLPP2) by Origin

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More Proteins for PHLPP2 Interaction Partners

Human PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) interaction partners

  1. Our studies not only first time identify PHLPP2 downregulation by lung carcinogen B[a]P/B[a]PDE (show ALDH7A1 Proteins), but also elucidate a novel molecular mechanisms underlying lung inflammation and carcinogenesis upon B[a]P/B[a]PDE (show ALDH7A1 Proteins) exposure.

  2. Results showed that PHLPP1 and PHLPP2 gene expression are down-regulated in esophageal squamous cell carcinoma. Their promotor is a target for mir (show MLXIP Proteins)-224.

  3. Data show that both serine/threonine phosphatases PHLPP and dephosphorylated the physiological substrates of Akt1 (show AKT1 Proteins) and Akt3 (show AKT3 Proteins) with similar efficiencies.

  4. Aberrant expression of PHLPP1 and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinoma

  5. miR (show MLXIP Proteins)-135a promotes cell proliferation in bladder cancer by targeting PHLPP2 and FOXO1 (show FOXO1 Proteins), and is performed as an onco-

  6. Data show that miR (show MLXIP Proteins)-372 modulated the expression of phosphoprotein phosphatase PHLPP2 by directly targeting its 3'-untranslated region (3'-UTR) and that miR (show MLXIP Proteins)-372 expression was inversely correlated with PHLPP2 expression in glioma samples.

  7. Results reveal PHLPP2 as a new biomarker of cancer progression, and implicate it as major negative regulator of NF-kappaB (show NFKB1 Proteins) signaling.

  8. miR (show MLXIP Proteins)-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis

  9. biochemical characterization of phosphatase domain of PHLPP1 and PHLPP2;PHLPP1 and PHLPP2 have similar in vitro activities and respond comparably to the presence of metallic ions; metallic ions affect structural stability of the domain;identified 3 residues likely involved in metal coordination and 2 that may be important for structural integrity

  10. This study reveals functional and mechanistic links between miRNA-224 and the tumor suppressors PHLPP1 and PHLPP2 in the pathogenesis of colorectal cancer

Mouse (Murine) PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) interaction partners

  1. PHLPP is a negative regulator of RAF1 (show RAF1 Proteins), which reduces colorectal cancer cell motility and prevents tumor progression in mice.

PHLPP2 Protein Profile

Protein Summary

Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.

Alternative names and synonyms associated with PHLPP2

  • PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2)
  • PH domain and leucine rich repeat protein phosphatase 2 (phlpp2)
  • PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2)
  • AI481772 protein
  • C130044A18Rik protein
  • Phlppl protein
  • RGD1562857 protein

Protein level used designations for PHLPP2

PH domain leucine-rich repeat-containing protein phosphatase 2 , PH domain and leucine rich repeat protein phosphatase 2 , PH domain leucine-rich repeat-containing protein phosphatase 2-like , GTPase activating protein and VPS9 domains 1

GENE ID SPECIES
454384 Pan troglodytes
489724 Canis lupus familiaris
533130 Bos taurus
707575 Macaca mulatta
733362 Xenopus laevis
100054529 Equus caballus
100145264 Xenopus (Silurana) tropicalis
100409942 Callithrix jacchus
100445641 Pongo abelii
100484269 Ailuropoda melanoleuca
100550506 Meleagris gallopavo
100581581 Nomascus leucogenys
23035 Homo sapiens
244650 Mus musculus
498949 Rattus norvegicus
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