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anti-Human PI3KR5 Antibodies:
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data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 (show PIK3R5 Antibodies) in PI3Kgamma (show PIK3CG Antibodies) activation.
PIK3R5 (show PIK3R5 Antibodies) promoter hypermethylation is associated with oral squamous cell carcinoma.
expression and activities of PI3Kgamma (show PIK3CG Antibodies) are modified differently by p87 and p101 (show PIK3R5 Antibodies) in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma (show PIK3CG Antibodies) signaling pathways.
Our characterization of the PIK3R5 (show PIK3R5 Antibodies) protein and findings suggest that it may play a role in the development of the cerebellum and vermis.
p101 (show PIK3R5 Antibodies) has a role in membrane recruitment and activation of PI3K gamma (show PIK3CG Antibodies)
analysis of functional domains in the p101 regulatory subunit of phosphoinositide 3-kinase gamma
Overexpression of p101 (show PIK3R5 Antibodies) activates PI3Kgamma (show PIK3CG Antibodies) signaling and is associated with T-cell lymphomas
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.
PI3-kinase p101 subunit
, phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
, phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit
, phosphoinositide 3-kinase regulatory subunit 5
, protein FOAP-2
, ptdIns-3-kinase p101