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Studies indicate that the Pten+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten is a key regulatory player in the PI3K/PTEN/AKT (show AKT1 Proteins) pathway.
our results offer significant insight into how PIK3CA overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 (show PDPK1 Proteins) and TGFb (show TGFB1 Proteins) signaling in advanced HNSCC patients with PIK3CA amplification
Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (show HSP90 Proteins) and the PI3K/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) pathway in prostate cancer.
Data indicate that chlorogenic acid (CGA (show CGA Proteins)) protected osteoblast MC3T3-E1 cells against oxidative damage via PI3K/Akt (show AKT1 Proteins)-mediated activation of Nrf2 (show NFE2L2 Proteins)/HO-1 (show HMOX1 Proteins) pathway, which may be an effective drug in treatment of osteoporosis.
Data show that macrophage M2 polarization was mediated through PTEN/PI3k/AKT (show AKT1 Proteins) pathway activation.
Constitutive Activation of PI3K is associated with Ovarian Granulosa Cell Tumors.
Together with recent identification of somatic mutations in p110a (encoded by PIK3CA), our data establish a potential mechanistic link between AGGF1 (show AGGF1 Proteins) and PIK3CA, the two genes identified for Klippel-Trenaunay syndrome (KTS)
p110beta has a role in mediating skeletal muscle metabolic signaling by regulating expression of AMP-activated protein kinase (show PRKAA2 Proteins)
The mRNA levels of leptin (show LEP Proteins) and of 17-beta-dehydrogenase 3, and enzyme important for testosterone production, were significantly higher in the testis of adult alpha-/- males( PI3K catalytic subunit p110alpha deletion).
Results suggest a role of ST6GalNAc I (show ST6GALNAC1 Proteins) in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT (show AKT1 Proteins)/NF-kappa B (show NFKB1 Proteins) signaling, and ST6GalNAc I (show ST6GALNAC1 Proteins) might be a marker for the prognosis and therapy of hepatocarcinoma.
These results indicated that dual targeting of PI3K and PERK pathways might improve clinical prognosis and enhance the treatment of ESCC patients.
These data indicate that increased irisin (show FNDC5 Proteins) levels may have protective roles in liver cancer cells through partial activation of the PI3K/AKT (show AKT1 Proteins) pathway, which may facilitate liver cancer progression and decrease the sensitivity to chemotherapy.
Mutant PIK3CA is a potent oncogenic driver in many urothelial carcinoma cell lines
we report a fourth patient with asymmetric overgrowth due to a somatic PIK3CA mutation who had nephroblastomatosis or Wilms tumor. Similar to two of three reported patients with a somatic PIK3CA mutation and renal tumors, he shared a PIK3CA mutation affecting codon 1047, presented at birth with asymmetric overgrowth, and had fibroadipose overgrowth.
Study developed a cancer stem cell model from a colorectal cancer patient-derived xenograft tumor and identified a PIK3CA (H1047R) mutation in the CSC population as a predictive biomarker to guide targeted therapy.
No significant impact on prognosis was observed for mutated KRAS, NRAS, and PIK3CA genes or combined RAS mutations
Single-nucleotide polymorphism in PIK3CA gene is associated with Insulin (show INS Proteins) Resistance.
Results showed that mutations in PIK3CA exons 9 and 20 were observed in 25 of the 208 (12 %) gastric cancer patients but found that no correlation with prognosis.
MicroRNA miR (show MLXIP Proteins)-155-5p promoted proliferation, invasion and migration, but inhibited apoptosis in hepatocellular carcinoma (HCC (show FAM126A Proteins)) by directly targeting the 3'-UTR of PTEN through the PI3K/Akt (show AKT1 Proteins) pathway.
Mosaic mutations in PIK3CA or PIK3R2 which activate class 1A PI3K cause severe non-ketotic hypoglycaemia in a subset of patients, with the metabolic phenotype presumably related to the extent of mosaicism within the liver.
There are multiple conformations in equilibrium during the course of PI3K SH3 domain unfolding.
PI3K has a role in activation of 5'-AMP (show TMPRSS5 Proteins)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
Production of PtdIns3P by PI3K-C2alpha (show PIK3C2A Proteins) is required for acquisition of fusion competence in neurosecretion.
crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
phosphoinositide-3-kinase, catalytic, alpha polypeptide
, Phosphoinositide-3-kinase, catalytic, alpha polypeptide
, PI3-kinase subunit alpha
, phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
, phosphoinositide-3-kinase catalytic alpha polypeptide
, ptdIns-3-kinase subunit alpha
, ptdIns-3-kinase subunit p110-alpha
, serine/threonine protein kinase PIK3CA
, PI3-kinase p110 subunit alpha
, phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha
, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform
, ptdIns-3-kinase p110
, phosphoinositide 3-kinase catalytic subunit