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Browse our PIK3CA Proteins (PIK3CA)

Full name:
Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide Proteins (PIK3CA)
On www.antibodies-online.com are 3 Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Proteins from 2 different suppliers available. Additionally we are shipping PIK3CA Antibodies (152) and PIK3CA Kits (5) and many more products for this protein. A total of 169 PIK3CA products are currently listed.
Synonyms:
6330412C24Rik, C-P3K, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, p110, p110-alpha, p110alpha, pi3-k, PI3-kinase, PI3K, PI3K-alpha
list all proteins Gene Name GeneID UniProt
PIK3CA 18706 P42337
PIK3CA 5290 P42336
Rat PIK3CA PIK3CA 170911  

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PIK3CA Proteins (PIK3CA) by Origin

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More Proteins for PIK3CA Interaction Partners

Mouse (Murine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp (show GC Proteins) gene by targeting BMAL1 (show ARNTL Proteins) and CLOCK.

  2. Analysis of 18 signalling signatures revealed that PI3K signalling is significantly induced whereas EGFR (show EGFR Proteins) signalling is significantly reduced in Pten() versus PIK3CA(H1047R) tumors. Thus, Pten() and PIK3CA(H1047R) tumors exhibit discernable differences that may impact tumorigenesis and response to therapy.

  3. activating PIK3CA mutations gives rise to sporadic venous malformations in mice, which closely resemble the histology of the human disease.

  4. These data demonstrate a causal relationship between activating Pik3ca mutations and the genesis of vascular malformations.

  5. data demonstrate that the PI3K p110alpha-Akt (show AKT1 Proteins)/Rac1 and NOX1 (show NOX1 Proteins) signalling pathways play a pivotal role in VEGF (show VEGFA Proteins)-induced vascular differentiation and cell migration.

  6. miR (show MLXIP Proteins)-490-5p functions as a tumour suppressor in renal carcinoma by targeting PIK3CA

  7. Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb (show ITPKB Proteins) restricts pre-T cell receptor (show PTCRA Proteins) induced metabolic activation to enforce coincidence-detection of pre-T cell receptor (show PTCRA Proteins) expression and Notch (show NOTCH1 Proteins)-engagement.

  8. Data show that RNA silencing of CCN family member 1 (show CYR61 Proteins) protein (CCN1 (show CCNA2 Proteins)) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT (show AKT1 Proteins) protein signaling in mouse pup model of oxygen-induced retinopathy (OIR).

  9. Reelin (show RELN Proteins) thus plays a role in restraining RAS and PI3-kinase promotion of cell motility and potentially tumour metastasis.

  10. demonstrated that despite having both Kras and Pik3ca mutations at the time of tumor initiation from loss of APC (show APC Proteins)

Human Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. PIK3CA gene mutations were sought in 145 tissue samples from central nervous system metastases of NSCLC using 3 PCR techniques. One E542K and two H1047R substitutions were found in male patients.

  2. Mutations in PIK3CA Sensitize Breast Cancer Cells to Physiologic Levels of Aspirin.

  3. Data show that the elevated activities of PI3Ks, AKt and GSK-3beta were effectively suppressed by exogenous carbon monoxide (CO), leading to the improvement of platelet function.

  4. PIK3CA and PIK3CB significantly increase multidrug resistance of CRC (show CALR Proteins) cells in vivo.

  5. Data underscore the importance of phosphatidylinositol 3-kinase (PI3K) signalling in myeloid cells in the context of chronic inflammatory diseases.

  6. Results indicate that eIF4B (show EIF4B Proteins) integrates the signals from Pim (show PIM1 Proteins) and PI3K/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) pathways in Abl (show ABL1 Proteins)-expressing leukemic cells.

  7. Patients with PIK3CA amplifications were more likely to have diffuse-type and poorly differentiated gastric cancers and were more likely to experience peritoneal recurrence compared with those without PIK3CA amplifications.

  8. The siRNA-induced AKT3 (show AKT3 Proteins) and PI3KCA mRNA knockdown.

  9. Pharmacophore model suggested the mechanism of the inhibition of PI3Kalpha and mTOR (show FRAP1 Proteins) by the compounds were mostly the same, which was supported by the docking study showing similar docking modes. The analysis also suggested the importance of the flat plane shape of the ligands, the space surrounding the ligands in the binding pocket, and the slight difference in the shape of the binding sites between PI3Kalpha and mTOR (show FRAP1 Proteins).

  10. PIK3CA gene plays a crucial role in carcinogenesis in general and head and neck squamous cell carcinoma in particular.

Cow (Bovine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. There are multiple conformations in equilibrium during the course of PI3K SH3 domain unfolding.

  2. PI3K has a role in activation of 5'-AMP (show TMPRSS5 Proteins)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  3. Production of PtdIns3P by PI3K-C2alpha (show PIK3C2A Proteins) is required for acquisition of fusion competence in neurosecretion.

  4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains

PIK3CA Protein Profile

Protein Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

Alternative names and synonyms associated with PIK3CA

  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA)
  • Phosphoinositide-3-kinase, catalytic, alpha polypeptide (GL50803_14855)
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca)
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (LOC100337822)
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca)
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca)
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA)
  • 6330412C24Rik protein
  • C-P3K protein
  • caPI3K protein
  • CLOVE protein
  • CWS5 protein
  • MCAP protein
  • MCM protein
  • MCMTC protein
  • p110 protein
  • p110-alpha protein
  • p110alpha protein
  • pi3-k protein
  • PI3-kinase protein
  • PI3K protein
  • PI3K-alpha protein

Protein level used designations for PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide , Phosphoinositide-3-kinase, catalytic, alpha polypeptide , PI3-kinase subunit alpha , PI3K-alpha , PI3Kalpha , phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphoinositide-3-kinase catalytic alpha polypeptide , ptdIns-3-kinase subunit alpha , ptdIns-3-kinase subunit p110-alpha , serine/threonine protein kinase PIK3CA , PI3-kinase p110 subunit alpha , phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha , phosphatidylinositol 3-kinase, catalytic, alpha polypeptide , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PI3K , p110alpha , ptdIns-3-kinase p110 , phosphoinositide 3-kinase catalytic subunit

GENE ID SPECIES
460858 Pan troglodytes
5702156 Giardia lamblia ATCC 50803
100144924 Xenopus (Silurana) tropicalis
100229768 Taeniopygia guttata
100337822 Oryctolagus cuniculus
18706 Mus musculus
5290 Homo sapiens
282306 Bos taurus
170911 Rattus norvegicus
488084 Canis lupus familiaris
424971 Gallus gallus
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