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Browse our PIK3CA Proteins (PIK3CA)

Full name:
Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide Proteins (PIK3CA)
On www.antibodies-online.com are 3 Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Proteins from 2 different suppliers available. Additionally we are shipping PIK3CA Antibodies (154) and PIK3CA Kits (5) and many more products for this protein. A total of 170 PIK3CA products are currently listed.
Synonyms:
6330412C24Rik, C-P3K, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, p110, p110-alpha, p110alpha, pi3-k, PI3-kinase, PI3K, PI3K-alpha
list all proteins Gene Name GeneID UniProt
PIK3CA 18706 P42337
PIK3CA 5290 P42336
Rat PIK3CA PIK3CA 170911  

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PIK3CA Proteins (PIK3CA) by Origin

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More Proteins for PIK3CA Interaction Partners

Mouse (Murine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. Results suggest a role of ST6GalNAc I (show ST6GALNAC1 Proteins) in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT (show AKT1 Proteins)/NF-kappa B (show NFKB1 Proteins) signaling, and ST6GalNAc I (show ST6GALNAC1 Proteins) might be a marker for the prognosis and therapy of hepatocarcinoma.

  2. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp (show GC Proteins) gene by targeting BMAL1 (show ARNTL Proteins) and CLOCK.

  3. Analysis of 18 signalling signatures revealed that PI3K signalling is significantly induced whereas EGFR (show EGFR Proteins) signalling is significantly reduced in Pten() versus PIK3CA(H1047R) tumors. Thus, Pten() and PIK3CA(H1047R) tumors exhibit discernable differences that may impact tumorigenesis and response to therapy.

  4. activating PIK3CA mutations gives rise to sporadic venous malformations in mice, which closely resemble the histology of the human disease.

  5. These data demonstrate a causal relationship between activating Pik3ca mutations and the genesis of vascular malformations.

  6. data demonstrate that the PI3K p110alpha-Akt (show AKT1 Proteins)/Rac1 and NOX1 (show NOX1 Proteins) signalling pathways play a pivotal role in VEGF (show VEGFA Proteins)-induced vascular differentiation and cell migration.

  7. miR (show MLXIP Proteins)-490-5p functions as a tumour suppressor in renal carcinoma by targeting PIK3CA

  8. Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb (show ITPKB Proteins) restricts pre-T cell receptor (show PTCRA Proteins) induced metabolic activation to enforce coincidence-detection of pre-T cell receptor (show PTCRA Proteins) expression and Notch (show NOTCH1 Proteins)-engagement.

  9. Data show that RNA silencing of CCN family member 1 (show CYR61 Proteins) protein (CCN1 (show CCNA2 Proteins)) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT (show AKT1 Proteins) protein signaling in mouse pup model of oxygen-induced retinopathy (OIR).

  10. Reelin (show RELN Proteins) thus plays a role in restraining RAS and PI3-kinase promotion of cell motility and potentially tumour metastasis.

Human Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. PTEN and PIK3CA were shown to be upregulated by 89 and 76% (western blot), respectively, in the pemetrexed-resistant cell line compared with control cells.

  2. High expression of PI3K is associated with glioma.

  3. PIK3CA mutations are associated with metastatic lung adenocarcinomas.

  4. Data show that zinc finger protein 143 (ZNF143 (show ZNF143 Proteins)) promotes epithelial-mesenchymal transition (EMT (show ITK Proteins)) through regulating PI3K/AKT (show AKT1 Proteins) pathway in gastric cancer (GC) cells.

  5. Mutations in PIK3CA, AKT1 (show AKT1 Proteins), and PTEN also were less frequently found in cancers with mutations in the DNA guardian, TP53 (show TP53 Proteins). This observation might seem counterintuitive because increased genome instability might facilitate development and selection of advantageous mutations.

  6. PIK3CA, PTEN, and AKT1 mutations occurred more frequently in the presence of hormone receptor overexpression (androgen, progesterone, or estrogen receptor). PIK3CA mutations were also more common in the HER2-positive than in the HER2-negative group; the opposite pattern was seen for PTEN mutation or PTEN loss

  7. High PI3K expression is associated with prostate cancer.

  8. PIK3CA gene mutations are associated with breast cancer

  9. Study shows that PIK3CA mutation occurs approximately in 45% of breast cancer patients, and are frequent in exon 20 in comparison with exon 9 of the gene. Also, PIK3CA mutations were found significantly associated with low-grade tumors.

  10. Data show that microRNA miR (show MLXIP Proteins)-221 targets PTEN protein, leading to activation of the PI3K/Akt (show AKT1 Proteins) pathway.

Cow (Bovine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. There are multiple conformations in equilibrium during the course of PI3K SH3 domain unfolding.

  2. PI3K has a role in activation of 5'-AMP (show TMPRSS5 Proteins)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  3. Production of PtdIns3P by PI3K-C2alpha (show PIK3C2A Proteins) is required for acquisition of fusion competence in neurosecretion.

  4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains

PIK3CA Protein Profile

Protein Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

Alternative names and synonyms associated with PIK3CA

  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA)
  • Phosphoinositide-3-kinase, catalytic, alpha polypeptide (GL50803_14855)
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca)
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (LOC100337822)
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca)
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca)
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA)
  • 6330412C24Rik protein
  • C-P3K protein
  • caPI3K protein
  • CLOVE protein
  • CWS5 protein
  • MCAP protein
  • MCM protein
  • MCMTC protein
  • p110 protein
  • p110-alpha protein
  • p110alpha protein
  • pi3-k protein
  • PI3-kinase protein
  • PI3K protein
  • PI3K-alpha protein

Protein level used designations for PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide , Phosphoinositide-3-kinase, catalytic, alpha polypeptide , PI3-kinase subunit alpha , PI3K-alpha , PI3Kalpha , phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphoinositide-3-kinase catalytic alpha polypeptide , ptdIns-3-kinase subunit alpha , ptdIns-3-kinase subunit p110-alpha , serine/threonine protein kinase PIK3CA , PI3-kinase p110 subunit alpha , phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha , phosphatidylinositol 3-kinase, catalytic, alpha polypeptide , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PI3K , p110alpha , ptdIns-3-kinase p110 , phosphoinositide 3-kinase catalytic subunit

GENE ID SPECIES
460858 Pan troglodytes
5702156 Giardia lamblia ATCC 50803
100144924 Xenopus (Silurana) tropicalis
100229768 Taeniopygia guttata
100337822 Oryctolagus cuniculus
18706 Mus musculus
5290 Homo sapiens
282306 Bos taurus
170911 Rattus norvegicus
488084 Canis lupus familiaris
424971 Gallus gallus
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