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Browse our PIK3CA Proteins (PIK3CA)

Full name:
Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide Proteins (PIK3CA)
On www.antibodies-online.com are 3 Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Proteins from 2 different suppliers available. Additionally we are shipping PIK3CA Antibodies (154) and PIK3CA Kits (8) and many more products for this protein. A total of 174 PIK3CA products are currently listed.
Synonyms:
6330412C24Rik, C-P3K, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, p110, p110-alpha, p110alpha, pi3-k, PI3-kinase, PI3K, PI3K-alpha
list all proteins Gene Name GeneID UniProt
PIK3CA 18706 P42337
PIK3CA 5290 P42336
Rat PIK3CA PIK3CA 170911  

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PIK3CA Proteins (PIK3CA) by Origin

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More Proteins for PIK3CA Interaction Partners

Mouse (Murine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. p110beta has a role in mediating skeletal muscle metabolic signaling by regulating expression of AMP-activated protein kinase (show PRKAA2 Proteins)

  2. The mRNA levels of leptin (show LEP Proteins) and of 17-beta-dehydrogenase 3, and enzyme important for testosterone production, were significantly higher in the testis of adult alpha-/- males( PI3K catalytic subunit p110alpha deletion).

  3. Results suggest a role of ST6GalNAc I (show ST6GALNAC1 Proteins) in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT (show AKT1 Proteins)/NF-kappa B (show NFKB1 Proteins) signaling, and ST6GalNAc I (show ST6GALNAC1 Proteins) might be a marker for the prognosis and therapy of hepatocarcinoma.

  4. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp (show GC Proteins) gene by targeting BMAL1 (show ARNTL Proteins) and CLOCK.

  5. Analysis of 18 signalling signatures revealed that PI3K signalling is significantly induced whereas EGFR (show EGFR Proteins) signalling is significantly reduced in Pten() versus PIK3CA(H1047R) tumors. Thus, Pten() and PIK3CA(H1047R) tumors exhibit discernable differences that may impact tumorigenesis and response to therapy.

  6. activating PIK3CA mutations gives rise to sporadic venous malformations in mice, which closely resemble the histology of the human disease.

  7. These data demonstrate a causal relationship between activating Pik3ca mutations and the genesis of vascular malformations.

  8. data demonstrate that the PI3K p110alpha-Akt (show AKT1 Proteins)/Rac1 and NOX1 (show NOX1 Proteins) signalling pathways play a pivotal role in VEGF (show VEGFA Proteins)-induced vascular differentiation and cell migration.

  9. miR (show MLXIP Proteins)-490-5p functions as a tumour suppressor in renal carcinoma by targeting PIK3CA

  10. Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb (show ITPKB Proteins) restricts pre-T cell receptor (show PTCRA Proteins) induced metabolic activation to enforce coincidence-detection of pre-T cell receptor (show PTCRA Proteins) expression and Notch (show NOTCH1 Proteins)-engagement.

Human Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. The expression of ribosomal and proteasomal components was significantly up-regulated in primary human colorectal tumors harboring PI3K pathway activation

  2. We revealed that activation of the PI3K/Akt (show AKT1 Proteins) pathway was the main cause of impaired autophagy in ELK3 (show ELK3 Proteins) KD. Our results suggest that targeting ELK3 (show ELK3 Proteins) may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics.

  3. CLOVES syndrome is an overgrowth syndrome caused by mosaic activating mutation in phosphoinositide-3-kinase, catalytic, alpha polypeptide (show ITGAE Proteins) (PIK3CA) gene.

  4. Data indicated next-generation sequencing (NGS) for the identification of somatic variation in the phosphoinositide-3-kinase, catalytic, alpha polypeptide (show ITGAE Proteins) (PIK3CA)-related overgrowth spectrum (PROS) among 14 patients submitted for clinical testing.

  5. Our data indicate that, similar to other benign proliferative lesions occurring in the breast parenchyma, activating PIK3CA mutations are very common in nipple adenomas

  6. Study identified PIK3CA mutation as an independent prognostic factor in patients who underwent APR (show LRP1 Proteins) for ASCC recurrence.

  7. Data show that acid sensing ion channel (show ACCN2 Proteins) 1a (ASIC1a (show ACCN2 Proteins)) mediated calcium influx, which resulted in the activation of PI3K/AKT (show AKT1 Proteins) signaling and increased drug resistance, suggesting that ASIC1a (show ACCN2 Proteins)/Ca(2 (show CA2 Proteins)+)/PI3K/AKT (show AKT1 Proteins) signaling represents a pathway that regulates drug resistance, thus offering a potential target for chemotherapy of hepatocellular carcinoma (HCC (show FAM126A Proteins)).

  8. Data, including data from hydrogen/deuterium exchange mass spectrometry studies using full-length constructs for both catalytic/p110alpha and regulatory/p85alpha subunits of phosphoinositide 3-kinase isoform, suggest that the catalytic subunit exhibits binding sites for four inhibitor compounds studied, including a low-affinity binding site for CAL (show FBLIM1 Proteins)-101.

  9. Bis (show BAG3 Proteins)(acetylacetonato)-oxidovanadium(IV) and sodium metavanadate induced the activation of both PI3K/AKT (show AKT1 Proteins) and MAPK/ERK (show MAPK1 Proteins) signaling pathways dose- and time-dependently.

  10. PIK3CA and AKT1 (show AKT1 Proteins) are frequently mutated in Hidradenoma papilliferum (HP) tumours (29% and 14%, respectively). PIK3CA/AKT1 (show AKT1 Proteins) pathway alterations in HP further support the hypothesis that HP is the vulvar (anogenital mammary-like gland) analogue of breast intraductal papilloma.

Cow (Bovine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. There are multiple conformations in equilibrium during the course of PI3K SH3 domain unfolding.

  2. PI3K has a role in activation of 5'-AMP (show TMPRSS5 Proteins)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  3. Production of PtdIns3P by PI3K-C2alpha (show PIK3C2A Proteins) is required for acquisition of fusion competence in neurosecretion.

  4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains

PIK3CA Protein Profile

Protein Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

Alternative names and synonyms associated with PIK3CA

  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA)
  • Phosphoinositide-3-kinase, catalytic, alpha polypeptide (GL50803_14855)
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca)
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (LOC100337822)
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca)
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca)
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA)
  • 6330412C24Rik protein
  • C-P3K protein
  • caPI3K protein
  • CLOVE protein
  • CWS5 protein
  • MCAP protein
  • MCM protein
  • MCMTC protein
  • p110 protein
  • p110-alpha protein
  • p110alpha protein
  • pi3-k protein
  • PI3-kinase protein
  • PI3K protein
  • PI3K-alpha protein

Protein level used designations for PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide , Phosphoinositide-3-kinase, catalytic, alpha polypeptide , PI3-kinase subunit alpha , PI3K-alpha , PI3Kalpha , phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphoinositide-3-kinase catalytic alpha polypeptide , ptdIns-3-kinase subunit alpha , ptdIns-3-kinase subunit p110-alpha , serine/threonine protein kinase PIK3CA , PI3-kinase p110 subunit alpha , phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha , phosphatidylinositol 3-kinase, catalytic, alpha polypeptide , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PI3K , p110alpha , ptdIns-3-kinase p110 , phosphoinositide 3-kinase catalytic subunit

GENE ID SPECIES
460858 Pan troglodytes
5702156 Giardia lamblia ATCC 50803
100144924 Xenopus (Silurana) tropicalis
100229768 Taeniopygia guttata
100337822 Oryctolagus cuniculus
18706 Mus musculus
5290 Homo sapiens
282306 Bos taurus
170911 Rattus norvegicus
488084 Canis lupus familiaris
424971 Gallus gallus
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