Browse our PIK3CA Proteins (PIK3CA)

Full name:
Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide Proteins (PIK3CA)
On www.antibodies-online.com are 3 Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Proteins from 2 different suppliers available. Additionally we are shipping PIK3CA Antibodies (158) and PIK3CA Kits (8) and many more products for this protein. A total of 178 PIK3CA products are currently listed.
Synonyms:
6330412C24Rik, C-P3K, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, p110, p110-alpha, p110alpha, pi3-k, PI3-kinase, PI3K, PI3K-alpha
list all proteins Gene Name GeneID UniProt
PIK3CA 18706 P42337
PIK3CA 5290 P42336
Rat PIK3CA PIK3CA 170911  

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PIK3CA Proteins (PIK3CA) by Origin

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More Proteins for PIK3CA Interaction Partners

Mouse (Murine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. Data indicate that chlorogenic acid (CGA (show CGA Proteins)) protected osteoblast MC3T3-E1 cells against oxidative damage via PI3K/Akt (show AKT1 Proteins)-mediated activation of Nrf2 (show NFE2L2 Proteins)/HO-1 (show HMOX1 Proteins) pathway, which may be an effective drug in treatment of osteoporosis.

  2. Data show that macrophage M2 polarization was mediated through PTEN/PI3k/AKT (show AKT1 Proteins) pathway activation.

  3. Constitutive Activation of PI3K is associated with Ovarian Granulosa Cell Tumors.

  4. Together with recent identification of somatic mutations in p110a (encoded by PIK3CA), our data establish a potential mechanistic link between AGGF1 (show AGGF1 Proteins) and PIK3CA, the two genes identified for Klippel-Trenaunay syndrome (KTS)

  5. p110beta has a role in mediating skeletal muscle metabolic signaling by regulating expression of AMP-activated protein kinase (show PRKAA2 Proteins)

  6. The mRNA levels of leptin (show LEP Proteins) and of 17-beta-dehydrogenase 3, and enzyme important for testosterone production, were significantly higher in the testis of adult alpha-/- males( PI3K catalytic subunit p110alpha deletion).

  7. Results suggest a role of ST6GalNAc I (show ST6GALNAC1 Proteins) in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT (show AKT1 Proteins)/NF-kappa B (show NFKB1 Proteins) signaling, and ST6GalNAc I (show ST6GALNAC1 Proteins) might be a marker for the prognosis and therapy of hepatocarcinoma.

  8. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp (show GC Proteins) gene by targeting BMAL1 (show ARNTL Proteins) and CLOCK.

  9. Analysis of 18 signalling signatures revealed that PI3K signalling is significantly induced whereas EGFR (show EGFR Proteins) signalling is significantly reduced in Pten() versus PIK3CA(H1047R) tumors. Thus, Pten() and PIK3CA(H1047R) tumors exhibit discernable differences that may impact tumorigenesis and response to therapy.

  10. activating PIK3CA mutations gives rise to sporadic venous malformations in mice, which closely resemble the histology of the human disease.

Human Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. Our study did not demonstrate a significant survival advantage from aspirin use in stage 2 PIK3CA mutated colon cancer (CC). The 'real-world' nature of our cohort and the subsequent uncontrolled differences in age and fitness in aspirin users are likely to have contributed to this result. In the PIK3CA mutated group, there was a trend towards improved recurrence-free survival of CC.

  2. The authors present three clinically challenging cases with congenital mosaic tissue overgrowth caused by a heterozygous missense mutation in PIK3CA in the affected tissue.

  3. Like the mammary intraductal papillomas, activating mutations in PIK3CA or AKT1 (show AKT1 Proteins) are present in most hidradenoma papilliferums.

  4. This work identifies PI3K signaling as an important target for precision medicine trials in meningioma patients

  5. PIK3CA plays a key role in promoting the proliferation and motility of esophageal squamous carcinoma cells.

  6. PIK3CA was overexpressed in Epstein Barr virus-associated gastric adenocarcinoma and was associated with a less aggressive phenotype and better prognosis.

  7. Data suggest HRas activates both p110alpha and p110delta isoforms; membrane-resident HRas, not soluble HRas, increases membrane recruitment of both p110alpha and p110delta. (HRas = v-Ha-ras Harvey rat sarcoma viral oncogene homolog; p110alpha = class IA phosphoinositide 3-kinases, subunit p110alpha; p110delta = class IA phosphoinositide 3-kinases, subunit p110delta)

  8. PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression.

  9. Somatic PIK3CA variants in breast cancers associate with rs252913 and rs331499 SNPs in the locus 5q11.2 locus.

  10. Derlin-1 (show DERL1 Proteins) is overexpressed in bladder cancer and promotes malignant phenotype through ERK (show EPHB2 Proteins)/MMP-2 (show MMP2 Proteins)/9 and PI3K/AKT (show AKT1 Proteins) signaling pathway.

Cow (Bovine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. There are multiple conformations in equilibrium during the course of PI3K SH3 domain unfolding.

  2. PI3K has a role in activation of 5'-AMP (show TMPRSS5 Proteins)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  3. Production of PtdIns3P by PI3K-C2alpha (show PIK3C2A Proteins) is required for acquisition of fusion competence in neurosecretion.

  4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains

PIK3CA Protein Profile

Protein Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

Alternative names and synonyms associated with PIK3CA

  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA)
  • Phosphoinositide-3-kinase, catalytic, alpha polypeptide (GL50803_14855)
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca)
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (LOC100337822)
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca)
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca)
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA)
  • 6330412C24Rik protein
  • C-P3K protein
  • caPI3K protein
  • CLOVE protein
  • CWS5 protein
  • MCAP protein
  • MCM protein
  • MCMTC protein
  • p110 protein
  • p110-alpha protein
  • p110alpha protein
  • pi3-k protein
  • PI3-kinase protein
  • PI3K protein
  • PI3K-alpha protein

Protein level used designations for PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide , Phosphoinositide-3-kinase, catalytic, alpha polypeptide , PI3-kinase subunit alpha , PI3K-alpha , PI3Kalpha , phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphoinositide-3-kinase catalytic alpha polypeptide , ptdIns-3-kinase subunit alpha , ptdIns-3-kinase subunit p110-alpha , serine/threonine protein kinase PIK3CA , PI3-kinase p110 subunit alpha , phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha , phosphatidylinositol 3-kinase, catalytic, alpha polypeptide , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PI3K , p110alpha , ptdIns-3-kinase p110 , phosphoinositide 3-kinase catalytic subunit

GENE ID SPECIES
460858 Pan troglodytes
5702156 Giardia lamblia ATCC 50803
100144924 Xenopus (Silurana) tropicalis
100229768 Taeniopygia guttata
100337822 Oryctolagus cuniculus
18706 Mus musculus
5290 Homo sapiens
282306 Bos taurus
170911 Rattus norvegicus
488084 Canis lupus familiaris
424971 Gallus gallus
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