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Our findings suggest that p84 (show PPP1R12C ELISA Kits) binding to p110gamma (show PIK3CG ELISA Kits) may represent a novel negative feedback signal that terminates PI3Kgamma (show PIK3CG ELISA Kits) activity.
expression and activities of PI3Kgamma (show PIK3CG ELISA Kits) are modified differently by p87 and p101 (show PIK3R5 ELISA Kits) in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma (show PIK3CG ELISA Kits) signaling pathways.
knockdown of p84 (show PPP1R12C ELISA Kits) in MDA-MB-231 cells enhanced Akt (show AKT1 ELISA Kits) phosphorylation and lung colonization
GPCR (show NMUR1 ELISA Kits) activation of Ras and PI3Kc in neutrophils depends on PLCb2 (show PLCb2 ELISA Kits)/b3 and the RasGEF RasGRP4 (show RASGRP4 ELISA Kits).
p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP]
ablation of PI3Kgamma (show PIK3CG ELISA Kits) reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells
RACK1 (show GNB2L1 ELISA Kits) regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC (show HSPG2 ELISA Kits) beta and PI3K gamma (show PIK3CG ELISA Kits)
These data demonstrate PI3Kgamma (show PIK3CG ELISA Kits)-dependent signalling downstream of IL-17RA (show IL17RA ELISA Kits), which plays a pivotal role in regulating IL-17 (show IL17A ELISA Kits) production in T cells.
GPCR (show GPBAR1 ELISA Kits) activation of Ras and PI3Kc in neutrophils depends on PLCb2 (show PLCb2 ELISA Kits)/b3 and the RasGEF RasGRP4 (show RASGRP4 ELISA Kits).
that genetic deletion of PI3Kgamma (show PIK3CG ELISA Kits) enhanced scratching behaviours in histamine-dependent and protease-activated receptor 2 (PAR-2 (show F2RL1 ELISA Kits))-dependent itch.
PI3Kgamma (show PIK3CG ELISA Kits) has a role in the induction of CXCR3 (show CXCR3 ELISA Kits) on T cells
Results suggest that the CXCR2 (show CXCR2 ELISA Kits) and PI3Kgamma (show PIK3CG ELISA Kits) signaling pathway may represent a suitable target for the development of novel therapeutic strategies for human diseases characterized by vascular leakage.
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors.
PI3Kgamma adapter protein of 87 kDa
, p84 PI3K adapter protein
, p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
, phosphoinositide 3-kinase regulatory subunit 6
, p87 PI3K adapter protein
, phosphoinositide 3-kinase gamma adapter protein of 87 kDa
, p87 phosphoinositide 3-kinase gamma adapter