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Our findings suggest that p84 (show PPP1R12C Proteins) binding to p110gamma (show PIK3CG Proteins) may represent a novel negative feedback signal that terminates PI3Kgamma (show PIK3CG Proteins) activity.
Colorectal cancer patients with high levels of Thoc1 (show THOC1 Proteins) expression had poorer overall-survival and disease-free survival, whereas those with lower levels of Thoc1 (show THOC1 Proteins) expression survived longer.
In humans, high THOC1 (show THOC1 Proteins) protein expression associates with prostate cancer aggressiveness and recurrence. Thus, THOC1 (show THOC1 Proteins) protein is a molecular marker that may improve the identification of aggressive prostate cancers, potentially reducing overtreatment.
Thoc1 (show THOC1 Proteins) inhibits cell growth via induction of cell cycle arrest and apoptosis in lung cancer cells.
expression and activities of PI3Kgamma (show PIK3CG Proteins) are modified differently by p87 and p101 (show PIK3R5 Proteins) in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma (show PIK3CG Proteins) signaling pathways.
This suggests NEDD4-1 (show NEDD4 Proteins) functions in conjunction with other post-translational mechanisms to regulate Thoc1 (show THOC1 Proteins) protein and THO (show THOC2 Proteins) activity.
overexpression of hTREX84 is associated with cancer cell transformation, proliferation and may be regulated by RelA/p65 (show NFkBP65 Proteins)
knockdown of p84 (show PPP1R12C Proteins) in MDA-MB-231 cells enhanced Akt (show AKT1 Proteins) phosphorylation and lung colonization
GPCR (show NMUR1 Proteins) activation of Ras and PI3Kc in neutrophils depends on PLCb2 (show PLCb2 Proteins)/b3 and the RasGEF RasGRP4 (show RASGRP4 Proteins).
We show that human THO (show THOC2 Proteins) depletion impairs transcription elongation and mRNA export and increases instability associated with DNA breaks, leading to hyper-recombination and gammaH2AX (show H2AFX Proteins) and 53BP1 (show TP53BP1 Proteins) foci accumulation
These data demonstrate PI3Kgamma (show PIK3CG Proteins)-dependent signalling downstream of IL-17RA (show IL17RA Proteins), which plays a pivotal role in regulating IL-17 (show IL17A Proteins) production in T cells.
GPCR (show GPBAR1 Proteins) activation of Ras and PI3Kc in neutrophils depends on PLCb2 (show PLCb2 Proteins)/b3 and the RasGEF RasGRP4 (show RASGRP4 Proteins).
that genetic deletion of PI3Kgamma (show PIK3CG Proteins) enhanced scratching behaviours in histamine-dependent and protease-activated receptor 2 (PAR-2 (show F2RL1 Proteins))-dependent itch.
p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP]
ablation of PI3Kgamma (show PIK3CG Proteins) reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells
PI3Kgamma (show PIK3CG Proteins) has a role in the induction of CXCR3 (show CXCR3 Proteins) on T cells
Results suggest that the CXCR2 (show CXCR2 Proteins) and PI3Kgamma (show PIK3CG Proteins) signaling pathway may represent a suitable target for the development of novel therapeutic strategies for human diseases characterized by vascular leakage.
HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).
PI3Kgamma adapter protein of 87 kDa
, p84 PI3K adapter protein
, p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
, phosphoinositide 3-kinase regulatory subunit 6
, p87 PI3K adapter protein
, phosphoinositide 3-kinase gamma adapter protein of 87 kDa
, THO complex subunit 1
, nuclear matrix protein p84