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synthesis of PtdIns(4,5)P(2) mediated by PIP5KIbeta is rate limiting for apical but not basolateral endocytosis in polarized kidney cells
The results suggested that PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis.
Phosphatidylinositol 4-phosphate 5-kinase (show PIP4K2C ELISA Kits) is essential for ROCK-mediated neurite remodeling
PIPKIalpha activity is involved in the actin remodeling that is a prerequisite for efficient phagocytosis
These results indicate that both Arf6 (show ARF6 ELISA Kits) and PIP5K (show PIKFYVE ELISA Kits) are involved in integrin-dependent bacterial uptake, and that Arf6 (show ARF6 ELISA Kits) participates in both activation of PIP5K (show PIKFYVE ELISA Kits) as well as in other events associated with bacterial uptake.
findings indicate that synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) by the three phosphatidylinositol 4-phosphate 5-kinase (show PIP4K2C ELISA Kits) (PIP5K (show PIKFYVE ELISA Kits)) isoforms Ialpha, Ibeta and Igamma is controlled by Rho GTPases
phosphatidylinositol phosphate kinase type I alpha is a negative regulator of FcepsilonRI (show FCER1A ELISA Kits)-mediated cellular responses and anaphylaxis.
after stimulation of a G protein-coupled receptor (show GPR34 ELISA Kits), IP(3) is completely derived from a rapidly synthesized discrete pool of PIP(2) synthesized by PIP5KIalpha and PIP5KIbeta
Data indicate that type I phosphatidylinositol 4-phosphate 5-kinase (show PIP4K2C ELISA Kits) PIP5KIbeta mutants whose dimerization was impaired showed a severe decrease in PI(4,5)P2 production and plasma membrane delocalization.
Knockdown of PIP5K1B in fibroblasts reproduced abnormal actin cytoskeleton remodeling evidenced in Friedreich's ataxia patient cells.
Results identify an isoform-specific PDZ (show INADL ELISA Kits)-binding motif in PIP5KIbeta, which confers specificity for PIP5KIbeta signaling at the uropod during leukocyte chemotaxis.
findings show that the human type I phosphatidylinositol 4-phosphate 5-kinase (show PIP4K2C ELISA Kits) isoform beta (PIPKIbeta) has a role in organizing signaling at the cell rear
Syk (show SYK ELISA Kits)-dependent phosphorylation of PIP5K1B is the dominant modification responsible for the decrease in cellular phosphatidylinositol 4,5-bisphosphate.
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
, phosphatidylinositol-4-phosphate 5-kinase type-1 beta-like
, phosphatidylinositol 4-phosphate 5-kinase type I alpha
, phosphatidylinositol 4-phosphate 5-kinase type I beta
, phosphatidylinositol 4-phosphate 5-kinase type-1 beta
, phosphatidylinositol-4-phosphate 5-kinase type I alpha
, phosphatidylinositol-4-phosphate 5-kinase type I beta
, phosphatidylinositol-4-phosphate 5-kinase type-1 beta
, ptdIns(4)P-5-kinase 1 beta
, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
, phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
, protein STM-7
, type I phosphatidylinositol 4-phosphate 5-kinase beta
, type I phosphatidylinositol-4-phosphate 5-kinase beta
, phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
, phosphatidylinositol-4-phosphate 5-kinase, type 1, beta
, ptdIns(4)P-5-kinase beta