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|Application / Reactivity||Mouse (Murine)|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||4 Antibodies|
|Immunofluorescence (IF)||13 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||12 Antibodies|
|Immunohistochemistry (IHC)||15 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||12 Antibodies|
|Immunoprecipitation (IP)||5 Antibodies|
|Western Blotting (WB)||57 Antibodies|
|Antigen||Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) Antibodies|
|Epitope||AA 88-116, Center Alternatives|
|Reactivity||Mouse (Murine) Alternatives|
Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
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|Predicted Reactivity||Cow (Bovine),Fruit Fly (Drosophila melanogaster),Pig (Porcine),Rat (Rattus),Rabbit|
|Purification||This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Immunogen||This PPP2CA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the Central region of human PPP2CA.|
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|Alternative Name||PPP2CA (PPP2CA Antibody Abstract)|
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
Synonyms: PPP2CA, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Replication protein C
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|Application Notes||WB: 1:1000|
|Restrictions||For Research Use only|
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|Buffer||Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.|
|Precaution of Use||WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.|
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|Product cited in:||
Schmitz, Held, Janssens et al.: "Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells." in: Nature cell biology, Vol. 12, Issue 9, pp. 886-93, 2010 (PubMed).
Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).
Pradhan, Alrehani, Patel et al.: "Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin αIIbβ3 to fibrinogen." in: The Journal of biological chemistry, Vol. 285, Issue 38, pp. 29059-68, 2010 (PubMed).
Antony, Lukiw, Bazan: "Neuroprotectin D1 induces dephosphorylation of Bcl-xL in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survival." in: The Journal of biological chemistry, Vol. 285, Issue 24, pp. 18301-8, 2010 (PubMed).
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