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mRNA expression analyses revealed PRR5 overexpression in a majority of colorectal tumors but substantial downregulation of PRR5 expression in a subset of breast tumors and reduced expression in two breast cancer cell lines
It was demonstrated that immunoprecipitation of Protor-1 or Protor-2 (show PRR5L ELISA Kits) results in the co-immunoprecipitation of other mTORC2 (show CRTC2 ELISA Kits) subunits, but not Raptor (show RPTOR ELISA Kits), a specific component of mTORC1.
The inhibition of Akt (show AKT1 ELISA Kits) and S6K1 (show RPS6KB1 ELISA Kits) phosphorylation by PRR5 knock down correlates with reduction in the expression level of platelet-derived growth factor receptor beta (show PDGFRB ELISA Kits) (PDGFRbeta).
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
Rho GTPase activating protein 8
, proline-rich protein 5
, protein observed with Rictor-1
, Protor-2 homolog