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Elevated levels of p-Mnk1 (show MKNK1 ELISA Kits), p-eIF4E (show EIF4E ELISA Kits) and p-p70S6K proteins are associated with tumor recurrence and poor prognosis in astrocytomas. Overexpression of p-eIF4E (show EIF4E ELISA Kits) and co-expression of p-Mnk1 (show MKNK1 ELISA Kits), p-eIF4E (show EIF4E ELISA Kits) and p-p70S6K proteins could be used as novel independent poor prognostic biomarkers for patients with astrocytomas.
ULK1 (show ULK1 ELISA Kits) has a role in RPS6KB1-NCOR1 (show NCOR1 ELISA Kits) repression of NR1H/LXR (show NR1H3 ELISA Kits)-mediated Scd1 (show SCD ELISA Kits) transcription and augments lipotoxicity in hepatic cells
function mimicked by the viral protein kinase encoded by open reading frame 36 of Kaposi's sarcoma-associated herpesvirus
our data suggest that RPS6KB1 is over-activated as p-RPS6KB1 in non-small cell lung cancer, rather than just the total protein overexpressing. The phosphorylation level of RPS6KB1 might be used as a novel prognostic marker for NSCLC patients.
p54 (show DDX6 ELISA Kits)-S6K2 (show RPS6KB2 ELISA Kits) interactome is predominant to the nucleus, whereas p70-S6K1 is predominant to cytosol.
S6K1 is involved in the regulation of mitochondria morphology and function in HeLa cells.
S6K1 acts through multiple targets of the mTOR (show FRAP1 ELISA Kits) pathway to promote self-renewal and leukemia progression
Data show that acquired immunodeficiency syndrome (AIDS) related diffuse large B-cell lymphoma (AR-DLBCL) frequently contain phosphorylated 70 ribosomal S6 protein-kinase (p70S6K), a main downstream effector of the mTOR serine-threonine kinases (mTOR) pathway, and the presence of p70S6K is positively correlated with phosphorylated phosphatase and tensin homolog (pPTEN).
S6K1 is a promising tumor-specific target for the enhancement of NSCLC radiosensitivity and its effects may be mediated by increased expression of PDCD4 (show PDCD4 ELISA Kits).
Spheroids showed relative lower activities in the AKT (show AKT1 ELISA Kits), mammalian target of rapamycin (mTOR (show FRAP1 ELISA Kits)) and S6K (also known as RPS6KB1) signaling pathway compared to cells cultured in two dimensions.
MYC (show MYC ELISA Kits) and S6K cooperate through coordinate activation of the essential Pol I transcription initiation factor TIF-1A (show RRN3 ELISA Kits).
This study showed that p70 S6 kinase (show PRKACB ELISA Kits) (S6k), acting downstream of the insulin receptor (InR (show INSR ELISA Kits)) and the small GTPase (show RACGAP1 ELISA Kits) Arf6 (show ARF6 ELISA Kits), is a key mediator of ethanol-induced sedation in Drosophila
our results indicate that S6K1 has an inhibitory effect on autophagic activity under normal nutritional conditions
S6 kinase localizes to the presynaptic active zone and functions with PDK1 (show PDPK1 ELISA Kits) to control synapse development
the effect of allelic variation at S6k on a range of phenotypes associated with metabolism and fitness in an age-, diet-, and sex-specific manner
Data show that female Drosophila melanogaster undergo a dietary switch following mating and that S6 kinase and serotonin production are involved in this switch.
Data show that mating status modulates food choice in females, that it relies on the action of the sex peptide receptor in sensory neurons, and that neuronal TOR/S6K function affects this decision, possibly signaling the fly's current nutritional status.
DHR3 (show ERCC2 ELISA Kits) modulates dS6 (show RPS6 ELISA Kits) kinase-dependent growth in Drosophila.
dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase 1, dPDK1, demonstrating that both dPDK1, as well as dTOR, mediated dS6K activation is phosphatidylinositide-3,4,5-trisphosphate (PIP3)-independent.
Rheb (show RHEB ELISA Kits) is an essential regulator of S6K in controlling cell growth in Drosophila.
Activation of S6K1-mediated protein synthesis and increased autophagy in white adipose tissue was detected in chronic alcohol fed animals.
we show that simultaneous inhibition of mTOR (show FRAP1 ELISA Kits) signaling to both S6K1 and 4E-BP1 (show EIF4EBP1 ELISA Kits) is sufficient to reduce AKT (show AKT1 ELISA Kits)-induced muscle growth and render it insensitive to the mTORC1-inhibitor rapamycin
transfection of cells with a constitutively active rapamycin-resistant p70S6K mutant could restore the mineralizing capacity of HtrA1 (show HTRA1 ELISA Kits)-deficient mouse adipose-derived stromal cells.
We provide mechanistic evidence that S6K1's negative feedback to PI3K signaling is involved in axon growth inhibition, and show that phosphorylation of S6K1 is a more appropriate regeneration indicator than is S6 phosphorylation.
S6K1 phosphorylation of H2B mediates EZH2 (show EZH2 ELISA Kits) trimethylation of H3 early in adipogenesis, contributing to the promotion of obesity.
the p70S6K isoforms have unique and redundant functions in mediating fibrogenic processes, including proliferation, migration.
Rcan2 (show RCAN2 ELISA Kits) and Rps6kb1 mutations both affect growth and body weight of mice, though likely through different mechanisms
Findings indicate that similar to overall cell size growth, Golgi growth is modulated by the "cell growth checkpoint" at late G1 phase through the activities of S6 kinase 1 (S6K1).
the results identify the JNK (show MAPK8 ELISA Kits)/S6K1 axis as a key molecular mechanism whereby a high fat/sucrose diet impairs insulin (show INS ELISA Kits) action in retina.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt (show AKT1 ELISA Kits), mTOR (show FRAP1 ELISA Kits), p70S6K, and ERK1/2 (show MAPK1/3 ELISA Kits).
Lys (show LYZ ELISA Kits), His, and Thr (show TRH ELISA Kits) inhibited S6K1 phosphorylation in bovine mammary cells
This study found that, early in rotavirus enteritis, arginine has no impact on diarrhea but augments intestinal protein synthesis in part by p70(S6k) stimulation.
There was no correlation of infarct size with expression or phosphorylation of p70S6K or GSK3beta (show GSK3b ELISA Kits) in ischemic postconditioning.
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17.
p70 S6 kinase, alpha
, ribosomal protein S6 kinase I
, ribosomal protein S6 kinase beta-1
, serine/threonine kinase 14 alpha
, serine/threonine-protein kinase 14A
, p70 S6 kinase
, S6 kinase
, dS6 kinase
, p70 ribosomal S6 kinase
, ribosomal S6 protein kinase
, ribosomal protein S6 kinase
, 70 kDa ribosomal protein S6 kinase 1
, p70 S6 kinase alpha
, p70 S6K-alpha
, p70 S6KA
, p70 ribosomal S6 kinase alpha
, p70-S6K 1
, ribosomal protein S6 kinase, 70kD, polypeptide 1
, ribosomal protein S6 kinase, 70kDa, polypeptide 1
, G3 serine/threonine kinase
, ribosomal protein S6 kinase polypeptide 1