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Experiments in Xenopus assembly extracts with M9M, a superaffinity nuclear localization sequence that displaces cargoes bound by transportin, or TLB, a mutant transportin that can bind cargo and RanGTP simultaneously, support direct inhibition.
Results show that tranportin 1 (AtTRN1) recognizes a broad spectrum of proteins having diverse functions, which will potentially be the cargoes of AtTRN1.
These results suggest that Aqp0a is the primary water channel (show AQP4 ELISA Kits) of the lens and that Aqp0b, though possibly a secondary water channel (show AQP4 ELISA Kits), has an unidentified function in the lens.
the TNPO1-Rab8 (show RAB8A ELISA Kits)-ciliary targeting signals complex mediates selective entry into and retention of cargos within cilia.
SIN1 (show MAPKAP1 ELISA Kits) plays an important role in non-small cell lung cancer; SIN1 (show MAPKAP1 ELISA Kits) is a potential biomarker and a promising target in the treatment of NSCLC
This study provides evidence that Sin1 (show MAPKAP1 ELISA Kits), a known element of the mammalian target of rapamycin (show FRAP1 ELISA Kits) complex 2 (mTORC2 (show CRTC2 ELISA Kits)), is required for Interferon-gamma (show IFNG ELISA Kits)-induced phosphorylation and activation of AKT (show AKT1 ELISA Kits) and that such activation mediates downstream regulation of mTORC1 and its effectors.
Together, these results indicate that transportin-1 mediates YB-1 (show YBX1 ELISA Kits) nuclear translocation.
findings suggest that a new player, i.e., O-GlcNAcylation, regulates hnRNP A1 translocation and interaction with Trn1, possibly affecting its function
Intracellular localization of mTORC2 (show CRTC2 ELISA Kits) component, mSin1, contributes to regulation of Akt (show AKT1 ELISA Kits) phosphorylation.
Importins, Impbeta, Kapbeta2, Imp4, Imp5, Imp7, Imp9, and Impalpha, show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 with KD values of 77 and 57 nm, respectively, and binds the other five Importins more weakly.
Results show that Karyopherin-b2 binds to the N-terminal tail of histone H3 (show HIST3H3 ELISA Kits) with high affinity even though H3 lacks a recognizable proline-tyrosine nuclear localization signal (PY-NLS (show ALDH1A2 ELISA Kits)).
FGF2 (show FGF2 ELISA Kits) nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase (show RAN ELISA Kits) in human glioblastoma cells
Akt (show AKT1 ELISA Kits) phosphorylates SIN1 (show MAPKAP1 ELISA Kits) at T86, enhancing mTORC2 (show CRTC2 ELISA Kits) kinase activity, which leads to phosphorylation of Akt (show AKT1 ELISA Kits) S473 by mTORC2 (show CRTC2 ELISA Kits), thereby catalyzing full activation of Akt (show AKT1 ELISA Kits).
Co-immunoprecipitation and affinity-binding studies revealed that Rab23 (show RAB23 ELISA Kits) exists in a complex with Kif17 and importin b2 implying that Kif17 needs to bind to regulatory proteins like Rab23 (show RAB23 ELISA Kits) for its ciliary transport
Association with Tnpo1 is necessary for Oxtr (show OXTR ELISA Kits) nuclear localization. This is required for Oxt (show OXT ELISA Kits)-induced osteoblast differentiation. osteoblast differentiation.
DJ-1 (show PARK7 ELISA Kits) import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.
Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin (show HTT ELISA Kits) protein.
Tnpo1 is involved in a variety of functions in the adult brain, including neurogenesis, cerebrospinal fluid production and sensing, and circadian rhythms.
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.
, major intrinsic protein of lens fiber 1
, MEKK2-interacting protein 1
, SAPK-interacting protein 1
, TORC2 subunit MAPKAP1
, mitogen-activated protein kinase 2-associated protein 1
, ras inhibitor MGC2745
, stress-activated map kinase interacting protein 1
, stress-activated map kinase-interacting protein 1
, stress-activated protein kinase-interacting 1
, target of rapamycin complex 2 subunit MAPKAP1
, M9 region interaction protein
, importin 2
, importin beta 2
, importin beta-2
, karyopherin (importin) beta 2
, karyopherin beta-2
, myocardial ischemic preconditioning up-regulated protein 1
, myocardial ischemic preconditioning upregulated 1