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HIP2 (show UBE2K ELISA Kits) regulates mitotic spindle alignment. SHIP2 is expressed in G1 phase, whereas Aurora A kinase (show AURKA ELISA Kits) is enriched in mitosis. SHIP2 binds Aurora A kinase (show AURKA ELISA Kits) and the scaffolding protein HEF1 (show NEDD9 ELISA Kits) and promotes their basolateral localization at the expense of their luminal expression connected with cilia resorption.
article focuses on the mutations associated with opsismodysplasia and explores the role of INPPL1/ SHIP2 in skeletal development (Review)
SHIP2 recruits Mena (show EGFR ELISA Kits) to invadopodia and disruption of SHIP2-Mena (show EGFR ELISA Kits) interaction in cancer cells leads to attenuated capacity for ECM (show MMRN1 ELISA Kits) degradation and invasion in vitro, as well as reduced metastasis in vivo.
In glioblastoma 1321 N1 cells, we recently identified Myo1c (show MYO1C ELISA Kits) as a new interactor of SHIP2. SHIP2 localization at lamellipodia and ruffles is impaired in Myo1c (show MYO1C ELISA Kits) depleted cells. In the absence of Myo1c (show MYO1C ELISA Kits), N1 cells tend to associate to form clusters.
decreased expression of transcription factor Sp1 (show SP1 ELISA Kits) contributes to suppression of SHIP2 in gastric cancer cells.
In order to shed light on the role of the C2 related (C2R) domain, immediately C-terminal to the SHIP2 phosphatase domain, molecular cloning, expression, purification and crystallization of the human SHIP2 fragment containing the phosphatase (Ptase) and C2R domains were performed an X-ray crystallographic data analysis was conducted.
Regulation of phosphatidylinositol 4,5-bisphosphate by SHIP2 controls glioblastoma cell migration through the organization of focal adhesions.
the dissociation process of the EphA2 (show EPHA2 ELISA Kits)-SHIP2 SAM-SAM (show TTN ELISA Kits) domain heterodimer complex the dissociation process of the EphA2 (show EPHA2 ELISA Kits)-SHIP2 SAM-SAM (show TTN ELISA Kits) domain heterodimer complex
Suppression of SHIP2 contributes to tumorigenesis and proliferation of gastric cancer cells via activation of Akt (show AKT1 ELISA Kits).
these findings suggest that SHIP2 is an important regulator of hepatic lipogenesis and lipoprotein secretion in insulin (show INS ELISA Kits) resistance state.
data suggest that endothelial SHIP2 is required to maintain normal systemic glucose homeostasis and prevent oxidative stress-induced (show SQSTM1 ELISA Kits) endothelial dysfunction.
The authors concluded that the FcgammaRIIb-SHIP2 axis links Abeta (show APP ELISA Kits) neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease.
These findings suggest that palmitate contributes to SHIP2 overexpression in skeletal muscle via the mechanisms involving the activation of ceramide-JNK (show MAPK8 ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) pathways.
results suggest that SHIP2 contributes to the regulation of food intake mainly via the attenuation of insulin (show INS ELISA Kits) signalling in the hypothalamus of mice
The catalytically-inactive Ship2 mutant protein in a context of reduced PtdIns(4,5)P2 3-kinase activity.
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
These results suggest that SHIP2 is a potent negative regulator of insulin (show INS ELISA Kits)/IGF-I (show IGF1 ELISA Kits) actions in the brain, and excess amounts of SHIP2 may be related, at least in part, to brain dysfunction in insulin (show INS ELISA Kits) resistance with type 2 diabetes.
The SHIP2 is a negative regulator of insulin (show INS ELISA Kits) signaling, our findings suggest the importance of the phosphoinositide metabolism at endocytic clathrin-coated pits in the regulation of insulin (show INS ELISA Kits) signal output.
Association with the insulin (show INS ELISA Kits) resistance of diabetic db/db (show LEPR ELISA Kits) mice.
The role of SHIP2 in controlling phosphatidylinositol 3,4,5-trisphosphate levels in platelets.
we suggest that SHIP2 might play a role in the regulation of skeletal muscle development in pigs
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.
SH2-domain-containing inositol 5-phosphatase 2b
, inositol polyphosphate phosphatase-like 1
, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2-like
, 51C protein
, SH2 domain-containing inositol 5'-phosphatase 2
, SH2 domain-containing inositol-5'-phosphatase 2
, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
, protein 51C
, SH2 domain-containing inositol phosphatase 2
, ablSH3-binding protein
, inositol polyphosphate phosphatase-like protein 1
, SH2-containing inositol phosphatase 2