Browse our SGPL1 Proteins (SGPL1)

Full name:
Sphingosine-1-Phosphate Lyase 1 Proteins (SGPL1)
On www.antibodies-online.com are 10 Sphingosine-1-Phosphate Lyase 1 (SGPL1) Proteins from 5 different suppliers available. Additionally we are shipping SGPL1 Antibodies (42) and SGPL1 Kits (13) and many more products for this protein. A total of 68 SGPL1 products are currently listed.
Synonyms:
AI428538, D10Xrf456, S1PL, SGPL1, Spgl1, spl, zgc:162153
list all proteins Gene Name GeneID UniProt
SGPL1 20397 Q8R0X7
SGPL1 8879 O95470
Rat SGPL1 SGPL1 286896 Q8CHN6

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SGPL1 Proteins (SGPL1) by Origin

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More Proteins for SGPL1 Interaction Partners

Mouse (Murine) Sphingosine-1-Phosphate Lyase 1 (SGPL1) interaction partners

  1. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis (show LBR Proteins) and adrenal insufficiency

  2. deleting SPL in CD11c (show ITGAX Proteins)(+) dendritic cells (DCs), rather than thymic epithelial cells or other stromal cells, disrupts the sphingosine-1-phosphate gradient, preventing egress.

  3. Studies suggest that S1PL is a novel endogenous suppressor of pulmonary fibrosis in human idiopathic pulmonary fibrosis and animal models.

  4. Although the observed inhibitory effect was not as strong as that of 4-deoxypyridoxine (a VB6 analog SPL inhibitor), these findings may be useful for further understanding the mechanism of action of THI.

  5. upregulation of multidrug resistance transporters contributes to the chemoresistance of S1P (show S1PR1 Proteins) lyase-deficient MEFs

  6. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3 (show STAT3 Proteins)-activated microRNAs.

  7. Findings suggest that sphingosine phosphate lyase (S1P (show S1PR1 Proteins) lyase) expressed in the thymic medullary perivascular spaces keeps the tissue sphingosine 1-phosphate low around the vessels and promotes thymic egress via up-regulation of S1P receptor 1 (S1P1 (show S1PR1 Proteins)).

  8. Data indicate that SGPL1 sphingosine 1-phosphate lyase (aldolase) mRNA is significantly increased in the periinfarct cortex.

  9. Leukocyte Sgpl1 as critical factor in monocyte macrophage differentiation and function.

  10. Inducible Sgpl1 knockout mice are protected in experimental autoimmune encephalomyelitis (EAE).

Human Sphingosine-1-Phosphate Lyase 1 (SGPL1) interaction partners

  1. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis (show LBR Proteins) and adrenal insufficiency

  2. Exposure to the combination of 100 muM genistein and 10 nM calcitriol reduced the number of proliferative cells to control levels, increased ERb (show ESR2 Proteins) and VDR (show CYP27B1 Proteins) expression, and reduced extracellular acidification (40%) as well as respiratory activity (70%), primarily in MG-63 cells..strong overexpression SGPL1, which irreversibly degrades sphingosine-1-phosphate thereby, generating ethanolamine

  3. Overexpression of sphingosine-1-phosphate lyase 1 (SGPL1), reverse the interleukin-8 (IL-8 (show IL8 Proteins)) secretion enhancing effect of microRNA miR (show MLXIP Proteins)-125b in trophoblast cell line HTR8/SVneo cells.

  4. Report a candidate gene (SGPL1) for autosomal recessive Charcot-Marie-Tooth disease with atypical disease course. Studies in patient-derived biosamples suggested that this phenotype is due to partial loss of SGPL1 function. Neuron-specific downregulation of the Drosophila orthologue impaired the morphology of the neuromuscular junction and caused progressive neurodegeneration

  5. increased SK and SPL mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.

  6. SPHK1 (show SPHK1 Proteins):SGPL1 ratio correlated with increased cellular sphingosine-1-phosphate (S1P (show MBTPS1 Proteins)), and S1P (show MBTPS1 Proteins) correlated with drug resistance (IC50).

  7. Results show that dissociation of SHP-1 (show PTPN6 Proteins) from spinophilin (show PPP1R9B Proteins) is followed by an increase in the binding of spinophilin (show PPP1R9B Proteins) to PP1 (show PPA1 Proteins).

  8. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3 (show STAT3 Proteins)-activated microRNAs.

  9. S1P (show MBTPS1 Proteins) lyase - by facilitating S1P1 (show S1PR1 Proteins) receptor recycling - is essential for S1P (show MBTPS1 Proteins)-mediated sustained signaling

  10. results highlight the importance of S1P (show MBTPS1 Proteins) in AD suggesting the existence of a global deregulation of S1P (show MBTPS1 Proteins) signaling in this disease from its synthesis by SphK1 (show SPHK1 Proteins) and degradation by SPL to its signaling by the S1P1 (show S1PR1 Proteins) receptor.

SGPL1 Protein Profile

Protein Summary

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.

Alternative names and synonyms associated with SGPL1

  • sphingosine-1-phosphate lyase 1 (SGPL1)
  • sphingosine-1-phosphate lyase 1 (sgpl1)
  • sphingosine phosphate lyase 1 (Sgpl1)
  • sphingosine-1-phosphate lyase 1 (Sgpl1)
  • AI428538 protein
  • D10Xrf456 protein
  • S1PL protein
  • SGPL1 protein
  • Spgl1 protein
  • spl protein
  • zgc:162153 protein

Protein level used designations for SGPL1

sphingosine-1-phosphate lyase 1 , spl , SP-lyase 1 , SPL 1 , mSPL , sphingosine-1-phosphate aldolase , hSPL , sphingosine phosphate lyase 1

GENE ID SPECIES
100072755 Equus caballus
423714 Gallus gallus
100037007 Xenopus laevis
100037312 Danio rerio
20397 Mus musculus
8879 Homo sapiens
522515 Bos taurus
286896 Rattus norvegicus
489032 Canis lupus familiaris
100525187 Sus scrofa
100173995 Pongo abelii
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