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This study revealed a significant variant (rs12455524) within the gene DLGAP1 (show DLGAP1 ELISA Kits) for Recurrent major depression.
These results strongly suggested involvement of the DLGAP1 (show DLGAP1 ELISA Kits) gene product in the development of HIV-related lipoatrophy in Thai HIV patients.
This study showed that DLGAP1 (show DLGAP1 ELISA Kits) association with obsessive-compulsive disorder.
DAP1 may have an important role in cell adhesion, migration and growth in the context of breast cancer and has significant associations with the apoptosis pathway.
Dimerization of DLC2 (show STARD13 ELISA Kits) was required for its interaction with GKAP (show DLGAP1 ELISA Kits), which, in turn, potentiated GKAP (show DLGAP1 ELISA Kits) self-association.
Results show that the expression and distribution of NMDA receptors subunits GluN1 (show GRIN1 ELISA Kits), GluN2A (show GRIN2A ELISA Kits) and GluN2B (show GRIN2B ELISA Kits) - together with that of postsynaptic protein PSD-95 (show DLG4 ELISA Kits) - are modified in Alzheimer's disease compared to normal aging
DAP1 was found to be correlated with disease progression and long-term survival of the colorectal patients. DAP1 is also a pivotal regulator of the growth and apoptosis and cellular response to chemotherapy agents.
dlgap1 (show DLGAP1 ELISA Kits) showed the highest association, of snps examined, with ocd.
This study demonstrates an inverse association between DAP1 mRNA levels and tumour stage and clinical outcome in breast cancer
Mapping of the phosphorylation sites and analysis of phosphorylation mutants indicated that DAP1 is functionally silenced in growing cells through mTOR (show FRAP1 ELISA Kits)-dependent phosphorylations on Ser3 and Ser51
These data suggest participation by both soluble and fibrillar aggregates in IAPP (show IAPP ELISA Kits)-induced islet inflammation. IAPP (show IAPP ELISA Kits)-induced activation of TLR2 (show TLR2 ELISA Kits) and secretion of IL-1 (show IL1A ELISA Kits) may be important therapeutic targets to prevent amyloid-associated beta cell dysfunction.
Hypothalamic amylin (show IAPP ELISA Kits) is transcriptionally regulated by leptin (show LEP ELISA Kits), that it can act directly on ObRb (show LEPR ELISA Kits) neurons in concert with leptin (show LEP ELISA Kits), and that it regulates feeding.
Matrix Metalloproteinase-9 (show MMP9 ELISA Kits) Protects Islets from Amyloid-induced Toxicity.
Data indicate that T-cell receptors that react to chromogranin A (ChgA (show CHGA ELISA Kits)) and islet amyloid polypeptide (show IAPP ELISA Kits) precursor (IAPP (show IAPP ELISA Kits)) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP (show PRSS16 ELISA Kits)).
Study the physiologic actions of IAPP (show IAPP ELISA Kits) on pancreatic beta cells, which secrete this peptide together with insulin (show INS ELISA Kits) upon glucose stimulation. Explore the signaling pathways and mitogenic actions of IAPP (show IAPP ELISA Kits) on beta cells.
deletion of the DeltaN isoforms of p63 (show CKAP4 ELISA Kits) or p73 (show ARHGAP24 ELISA Kits) leads to metabolic reprogramming and regression of p53 (show TP53 ELISA Kits)-deficient tumours through upregulation of IAPP (show IAPP ELISA Kits), the gene that encodes amylin (show IAPP ELISA Kits), a 37-amino-acid peptide co-secreted with insulin (show INS ELISA Kits) by the beta cells of the pancreas
The stability, conformational dynamics and association force of different single-layer models of the full-length wild-type and glycine mutants of amylin (show IAPP ELISA Kits), were investigated.
studies have identified a novel TXNIP (show TXNIP ELISA Kits)/miR (show MLXIP ELISA Kits)-124a/FoxA2 (show FOXA2 ELISA Kits)/IAPP (show IAPP ELISA Kits) signaling cascade linking the critical beta-cell signaling pathways of TXNIP (show TXNIP ELISA Kits) and IAPP (show IAPP ELISA Kits)
MMP-9 (show MMP9 ELISA Kits) constitutes an endogenous islet protease that limits islet amyloid deposition and its toxic effects via degradation of hIAPP.
Data suggest that amylin (show IAPP ELISA Kits) and leptin (show LEP ELISA Kits) play additive roles in regulating energy homeostasis via activation of overlapping signalling pathways; mechanisms may be different in hypothalamus, muscle, and liver and in cases of endoplasmic reticulum stress.
Part of the postsynaptic scaffold in neuronal cells.
, death associated protein 1
, death-associated protein 1
, PSD-95/SAP90 binding protein 1
, SAP90/PSD-95-associated protein 1
, disks large-associated protein 1
, guanylate kinase-associated protein
, diabetes-associated peptide