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Results show that Fis1 is significantly overexpressed in malignant oncocytomas.
Study revealed that a novel mitochondrial fission pathway composed of miR-483-5p and FIS1 regulates cisplatin sensitivity.
PDCD7 (show PDCD7 Proteins), Ang2 (show ANGPT2 Proteins) and FIS1 may indicate a more aggressive form and poor prognosis of acute myeloid leukemia (show BCL11A Proteins).
Overexpression of FoxM1 and Plk1 in Fis1-depleted cells restores mitotic entry.
Fis1 expression is significantly increased in spinal cord in a transgenic mouse model of amyotrophic lateral sclerosis.
MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria.
Fis1 acts as a mitochondrial recruitment factor for TBC1D15 (show TBC1D15 Proteins) that is involved in regulation of mitochondrial morphology.
PEX11 proteins attract both Mff (show MFF Proteins) and human Fis1 (hFis1) to their site of action.
Fis1 and dynamin-related protein (Drp)1 levels are remarkably increased in peripheral blood lymphocytes of Alzheimer's disease patients.
Fis1 activity depends on its ability to interconvert between monomer and dimer species
Our data confirm that FIS1 is a key regulator in pancreatic beta cells, because both glucose-stimulated insulin (show INS Proteins) secretion and mitochondrial dynamics were clearly adapted to precise expression levels of this fission protein.
we find that either MiD49 (show SMCR7 Proteins) or MiD51 (show SMCR7L Proteins) can mediate Drp1 (show CRMP1 Proteins) recruitment and mitochondrial fission in the absence of Fis1 and Mff (show MFF Proteins)
miR-484 attenuate Fis1 and mitochondrial fission by binding to N-terminal of Fis1 and inhibiting its translation.
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003
, TPR repeat protein 11
, mitochondrial fission 1 protein
, tetratricopeptide repeat domain 11
, tetratricopeptide repeat protein 11
, fis1 homolog